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Peony seed oil self-emulsifying system composition and preparation method thereof

A technology of peony seed oil and composition, applied in the field of medicine, can solve the problems of increased acid value and oxidation value, migration of capsule substances, leakage of oily components, etc., and achieves high dispersibility, improved bioavailability, and reduced dosage. Effect

Inactive Publication Date: 2016-06-29
GUANGZHOU OUHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, existing soft capsules containing peony seed oil have the defect of low bioavailability
In addition, making peony seed oil into soft capsules requires overcoming some difficulties, such as unqualified disintegration during storage, material migration and leakage of oily components in the capsule, stability problems such as increased acid value and oxidation value

Method used

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  • Peony seed oil self-emulsifying system composition and preparation method thereof
  • Peony seed oil self-emulsifying system composition and preparation method thereof
  • Peony seed oil self-emulsifying system composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Preparation of soft capsules with peony seed oil self-emulsifying system

[0044] The composition of peony seed oil self-emulsifying system soft capsules is shown in Table 1.

[0045] Table 1 Composition of peony seed oil self-emulsifying system soft capsules

[0046]

[0047]S1. Mix soybean lecithin, glycerin, sorbitol, vitamin E and polyethylene glycol-400 as shown in Table 1, and stir twice with a shearing machine (8000 rpm), for the first time for 5 minutes, and for the second time 2 minutes to make it evenly dispersed;

[0048] S2. Add warm peony seed oil, stir 3 times for 2 minutes each time to make colostrum, then transfer to a high-pressure homogenizer for homogenization 3 times, filter to form a uniform peony seed oil emulsion concentrate, That is, the self-emulsifying system composition A of peony seed oil;

[0049] S3. Add gelatin into the sol tank, add proportioned 80°C water, add preservative ethylparaben, add opacifier and coloring agent if necessary...

Embodiment 2

[0051] Preparation of peony seed oil self-emulsifying soft capsules II

[0052] The composition of peony seed oil self-emulsifying system soft capsules is shown in Table 2.

[0053] Table 2 Composition of peony seed oil self-emulsifying system soft capsules

[0054]

[0055] S1. Mix soybean lecithin, glycerin, sorbitol, vitamin E and polyethylene glycol-400 as shown in Table 2, and stir twice with a shearing machine (8000 rpm), for the first time for 5 minutes, and for the second time 2 minutes to make it evenly dispersed;

[0056] S2. Add warm peony seed oil, stir 3 times for 2 minutes each time to make colostrum, then transfer to a high-pressure homogenizer for homogenization 3 times, filter to form a uniform peony seed oil emulsion concentrate, That is, the self-emulsifying system composition B of peony seed oil;

[0057] S3. Add gelatin into the sol tank, add proportioned 80°C water, add preservative ethylparaben, add opacifier and coloring agent if necessary, seal a...

Embodiment 3

[0059] Preparation of soft capsules with peony seed oil self-emulsifying system

[0060] The composition of peony seed oil self-emulsifying system soft capsules is shown in Table 3.

[0061] Table 3 Composition of peony seed oil self-emulsifying system soft capsules

[0062]

[0063] S1. benzaze 30, 1, 2-propanediol, sorbitol, vitamin E and polyoxyethylene fatty acid ester are mixed as shown in table 3, and are stirred twice with a shearing machine (8000 rev / min), the first time 5 Minutes, 2 minutes for the second time to make it evenly dispersed;

[0064] S2. Add warm peony seed oil, stir 3 times for 2 minutes each time to make colostrum, then transfer to a high-pressure homogenizer for homogenization 3 times, filter to form a uniform peony seed oil emulsion concentrate, That is, the self-emulsifying system composition C of peony seed oil;

[0065] S3. Add gelatin into the sol tank, add proportioned 80°C water, add preservative ethylparaben, add opacifier and coloring a...

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Abstract

The invention provides a peony seed oil self-emulsifying system composition and a preparation method thereof. The self-emulsifying system composition comprises peony seed oil, an emulsifier and a co-emulsifier, further comprises a dispersing agent and / or a solid adsorbing agent and can be prepared into soft capsules, liquid capsules, hard capsules, granules and other oral dosage forms. After the self-emulsifying system composition enters the human body, self-micro-emulsification can be performed under the effect of gastrointestinal fluid, and absorption of the composition in the stomach and intestinal tracts can be promoted, so that the biological availability and effects of the peony seed oil self-emulsifying system composition are improved, side effects are small, and the treatment compliance of a patient for oral dosage medicine based on the peony seed oil self-emulsifying system composition can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a peony seed oil self-emulsifying system composition. Background technique [0002] Peony seed oil is a hydrophobic golden yellow transparent oil extracted from peony seeds. Peony seed oil is currently produced in my country, and it is a natural vegetable oil resource that has attracted much attention recently. The chemical composition of peony seed oil is mainly fatty acids, containing a large amount of unsaturated fatty acids (UFA), the total amount of which is about 80% to 92%, which is significantly higher than that of olive oil, soybean oil and peanut oil known as "liquid gold". vegetable oil. It is particularly noteworthy that the UFA composition in peony seed oil is mainly α-linolenic acid, with a content generally ranging from 32% to 67%, which is much higher than other common vegetable oils and similar to linseed oil. In addition to the obvious advantages...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61K47/44A61K9/107A61P9/10A61P3/06A61P39/06A61P1/16A61P3/10A61P37/04
CPCA61K36/71A61K9/107A61K9/1617A61K9/4858A61K36/65A61K47/44
Inventor 陈惠良李颖陈桂恩陈桂柱陈展权
Owner GUANGZHOU OUHUA PHARMA
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