Sensor based on concentration cell principle

A concentration battery and sensor technology, which is applied in the field of chemical sensing, can solve the problems of increasing cost, increasing electrode manufacturing steps, and complex blood components, and achieves the effects of low cost, improved detection accuracy, and simple manufacturing process

Inactive Publication Date: 2016-07-20
SOUTHEAST UNIV
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Problems solved by technology

Blood glucose sensors mostly use a three-electrode system, namely working electrode, reference electrode and counter electrode. The reference electrode is often made of materials different from the working electrode and counter electrode, such as silver-silver chloride electrode. The increased electrode manufacturing steps improve the cost
In addition, due t...

Method used

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  • Sensor based on concentration cell principle
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  • Sensor based on concentration cell principle

Examples

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Embodiment 1

[0027] Example 1 Using a sensor based on the principle of a concentration cell to detect blood sugar

[0028] For blood glucose detection, the reaction reagent in the first electrochemical cell 3 is a 0.01M phosphate buffer solution (pH7.4) containing 5kU / mL glucose oxidase and 500mM potassium ferricyanide. The reaction reagent in the second electrochemical cell 4 is 0.01M phosphate buffer solution (pH7.4) containing 500mM potassium ferricyanide. Before testing, the system was freeze-dried.

[0029] During the detection, the blood sample to be tested is added to the electrochemical cell, mixed with the reaction reagent and reacted for 200 seconds, and the electrical signals on the two electrodes are detected by the electrochemical workstation. By detecting the standard blood sample (that is, the blood sample with known concentration of the analyte), the quantitative relationship between the blood glucose concentration and the detection signal can be obtained, that is, the sta...

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Abstract

The invention relates to a sensor based on a concentration cell principle. The sensor is used for quantitatively detecting glucose concentration in human blood. As shown in the figures, the sensor comprises two electrodes (1) and (2), wherein the electrodes are in contact with solutions in two electrochemical pools (3) and (4), respectively; the two electrochemical pools have ion exchange through a nafion film (5); electro-active materials are contained in the two electrochemical pools (3) and (4). In the detection process, to-be-detected matter in a sample changes the concentrations of the electro-active materials in the electrochemical pools by reacting, thereby changing an electric signal (such as current or voltage) between the two electrodes; quantitative detection is performed by detecting a relation between the electric signal detected by (6) and the concentration of the to-be-detected matter. A reference electrode (such as a silver/silver chloride electrode) required by traditional electrochemical sense is not required by the sensor, the two electrodes can be made of the same material (such as graphite), the manufacturing technique is simple, and the cost is low; the influences of interfering matter in a sample on the detection can be eliminated, and thus the detection accuracy is increased.

Description

technical field [0001] The invention belongs to the field of chemical sensing, and specifically relates to a sensor based on the principle of a concentration-difference battery, which is applied to the determination of glucose content in human blood. Background technique [0002] Electrochemical sensors have the advantages of simple equipment, low cost, low power consumption, miniaturization, and quantitative detection, and have been widely used in on-site rapid detection. The most typical example is the blood glucose sensor, which currently accounts for 80% of the biosensor market. Blood glucose sensors mostly use a three-electrode system, namely working electrode, reference electrode and counter electrode. The reference electrode is often made of materials different from the working electrode and counter electrode, such as silver-silver chloride electrode. The increased electrode manufacturing steps improve the costs. In addition, due to the complex composition of blood,...

Claims

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Application Information

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IPC IPC(8): G01N27/413
CPCG01N27/413
Inventor 刘宏孙觅辛丽斐
Owner SOUTHEAST UNIV
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