Gold nanorod/silicon dioxide/carbon point nanometer hybrid material and preparation method and application thereof

A technology of nano-hybrid materials and gold nanorods, which is applied in the field of biological imaging, can solve the problems of fluorescence scintillation and toxicity, and achieve the effects of simple and controllable preparation method, good dispersion, and good diffuse reflection imaging effect

Active Publication Date: 2016-08-03
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Semiconductor quantum dots and fluorescent dyes can be applied in the field of optical imaging due to their unique fluorescent properties, but their application is greatly limited by the fluorescence scintillation and toxicity. Therefore, it is necessary to find a fluorescent material with higher biocompatibility to meet the needs of diseases in vivo. diagnostic needs

Method used

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  • Gold nanorod/silicon dioxide/carbon point nanometer hybrid material and preparation method and application thereof
  • Gold nanorod/silicon dioxide/carbon point nanometer hybrid material and preparation method and application thereof
  • Gold nanorod/silicon dioxide/carbon point nanometer hybrid material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Preparation of nano-hybrid materials of gold nanorods / silica / carbon dots

[0048] 1) Preparation of gold nanorods

[0049] a. Add 0.25ml of HAuCl with a concentration of 0.01mol / L 4 aqueous solution and 0.6ml ice-bathed NaBH with a concentration of 0.01mol / L 4 The aqueous solution was sequentially added to 7.5ml of CTAB aqueous solution with a concentration of 0.01mol / L, and after standing at a constant temperature of 30°C for 2 hours, a seed crystal solution was obtained;

[0050] b. Add 10ml of HAuCl with a concentration of 0.01mol / L 4 Aqueous solution, 1.5ml of AgNO with a concentration of 0.01mol / L 3 Aqueous solution, 5ml concentration is the HCl aqueous solution of 1mol / L and 0.32ml concentration is that the ascorbic acid aqueous solution of 0.1mol / L joins in the CTAB aqueous solution that 200ml concentration is 0.1mol / L, obtains the 4th mixture, when the 4th mixture changes from orange yellow to If it is colorless, add 480 μl of the seed crystal solution to th...

Embodiment 2

[0073] In addition to changing the volume of the silane-functionalized carbon point of N-(β-aminoethyl)-γ-aminopropylmethyldimethoxy in step 4) in Example 1 to 2ml, the others are implemented according to A gold nanorod / silicon dioxide / carbon dot nano-hybrid material was prepared in the same manner as Example 1.

[0074] The diameter of the carbon point in the nano-hybrid material of the gold nanorod / silicon dioxide / carbon point is 2-3nm, and the thickness of the silicon dioxide layer is 40nm; the nanometer of the gold nanorod / silicon dioxide / carbon point The hybrid material has two absorption peaks at 510nm and 770nm in the ultraviolet-visible absorption spectrum, and the emission peak of its fluorescence emission spectrum is 400-500nm.

[0075] Application of nano-hybrid materials of gold nanorods / silica / carbon dots in diffuse reflectance imaging

[0076] The test method is the same as in Example 1, and the performance of the gold nanorod / silicon dioxide / carbon dot nano-hyb...

Embodiment 3

[0080] Except that the concentration of the NaOH solution in step 4) in Example 1 was changed to 0.5 mol / L, the others were prepared in the same manner as in Example 1 to prepare a nano-hybrid material of gold nanorods / silicon dioxide / carbon dots.

[0081]The diameter of the carbon point in the nano-hybrid material of the gold nanorod / silicon dioxide / carbon point is 2-3nm, and the thickness of the silicon dioxide layer is 15nm. In the ultraviolet-visible absorption spectrum, the gold nanorod / carbon dioxide The silicon / carbon dot nano-hybrid material has two absorption peaks at 510nm and 710nm, and the emission peak of its fluorescence emission spectrum is 400-500nm.

[0082] Application of nano-hybrid materials of gold nanorods / silica / carbon dots in diffuse reflectance imaging

[0083] The test method is the same as in Example 1, and the performance of the gold nanorod / silicon dioxide / carbon dot nano-hybrid material in diffuse emission imaging is similar to that of Example 1. ...

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Abstract

The invention discloses a gold nanorod/silicon dioxide/carbon point nanometer hybrid material. The nanometer hybrid material comprises a gold nanorod as a core, a silicon dioxide layer as a shell, and carbon points distributed on the outer surface of the silicon dioxide layer; and the nanometer hybrid material is obtained by a coupling effect between the silicon dioxide layer coating the outer surface of the gold nanorod and silane functional carbon points containing amido. The invention further discloses a preparation method of the gold nanorod/silicon dioxide/carbon point nanometer hybrid material. The preparation method of the gold nanorod/silicon dioxide/carbon point nanometer hybrid material is simple and controllable. The gold nanorod/silicon dioxide/carbon point nanometer hybrid material realizes application to diffuse reflection imaging through the gold nanorod, realizes application to fluorescent life imaging through the carbon points, realizes non-intrusive multi-mode imaging, and is excellent in application prospect in the cancer diagnosis.

Description

technical field [0001] The invention relates to the technical field of biological imaging. More specifically, it relates to a gold nanorod / silicon dioxide / carbon dot nano-hybrid material and its preparation method and application. Background technique [0002] Research into multimodal imaging agents is an active area of ​​interest during non-invasive bioimaging. Gold nanoparticles have a surface plasmon effect (SPR), and have significant absorption and scattering properties in the visible and near-infrared light regions. Therefore, gold nanoparticles usually perform high-resolution and high-sensitivity photodetection on tumor cells and atherosclerotic sites. Scatter imaging. Because of their unique size and shape-dependent optical properties, gold nanoparticles can serve as good contrast agents in imaging systems. At the lesion site, the optical properties of gold nanoparticles change to improve imaging contrast. Diffuse reflectance imaging (DR) is a new type of optical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F1/02B22F9/24B82Y40/00B82Y30/00B82Y20/00G01N21/64G01N21/47
CPCG01N21/4738G01N21/6486B82Y20/00B82Y30/00B82Y40/00B22F9/24B22F1/16
Inventor 周树云刘晓静谢政德罗尔·戴维·菲克斯乐刘璐婷
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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