Cu<2+> chemical sensor, and preparation method and application thereof

A chemical sensor and nanomaterial technology, applied in the field of preparation of Cu2+ chemical sensor, can solve the problems of large background interference, complicated operation, tedious sample preparation, etc., and achieve the effects of good selectivity, simple detection process and accurate results.

Inactive Publication Date: 2016-08-17
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in comparison, other methods are complicated to operate, cumbersome to prepare samples, have large background interference, and are expensive, while fluorescence spectroscopy has the advantages of rapid detection, sensitivity, good selectivity, and low detection limit.

Method used

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  • Cu&lt;2+&gt; chemical sensor, and preparation method and application thereof
  • Cu&lt;2+&gt; chemical sensor, and preparation method and application thereof
  • Cu&lt;2+&gt; chemical sensor, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Cu 2+ Preparation of the sensor:

[0024] (1) The preparation steps of MOF nanomaterials are: weigh Zn(NO) 3 ·6H 2 O 0.298g and 2-methylimidazole 0.246g were dissolved in 15mL of methanol respectively, then the two were mixed and transferred to a 100mL hydrothermal reaction kettle, reacted at a constant temperature of 80°C for 24h, and washed with methanol for 3 times, 100 °C and vacuum dried for 24 hours to obtain ZIF-8 solid powder.

[0025] (2)Cu 2+ Preparation of fluorescent probe: Weigh pyrimidine hydrochloride (C 8 h 9 NO 3 HCl) 0.4072g, fully dissolved in 10mL absolute ethanol, then add 85% hydrazine hydrate (N 2 h 4 ·H 2 (0) 2 ~ 5mL, reflux at 70 ~ 80 ° C for 8 h, cooling, after the crystals are precipitated, filter, wash, and then vacuum dry at 60 ° C for 24 h to obtain a solid powder, its nuclear magnetic spectrum is as follows figure 1 . The stoichiometric ratio of described pyridoxal hydrochloride and hydrazine hydrate is 1:1.

[0026]...

Embodiment 2

[0027] Example 2: Fluorescent Probes and Sensors on Cu 2+ Applications in testing

[0028] (1) Preparation of fluorescent probe solution: Accurately take 18.1 mg of fluorescent probe, dissolve it with 80 mL of absolute ethanol, transfer it to a 100 mL volumetric flask, and prepare a concentration of 1.0×10 -3 mol / L fluorescent probe stock solution (stored at a constant temperature at 4°C).

[0029] (2) Preparation of the new sensor stock solution: Take 100 mg of the new sensor, dissolve it in 90 mL of solvent (deionized water: absolute ethanol = 8:1), transfer it to a 100 mL volumetric flask to constant volume (keep it at a constant temperature at 4°C) ).

[0030] (3) Fluorescent probes for Cu 2+ Detection: the wavelength of the excitation light is set to 358nm, the wavelength of the emission light is set to 471nm, the slit of the excitation light source is 10.0nm, the slit of the emission light source is 10.0nm, and the test condition is normal temperature. Take 3mL of 0....

Embodiment 3

[0032] Embodiment 3: novel sensor pair Cu 2+The wavelength of the excitation light is set to 358nm, and the wavelength of the emission light is set to 471nm. Take 3mL of 0.01mol / L PBS buffer solution with pH=9 and 20μL of 1.0g / L new sensor stock solution and add them to 15 clean fluorescence ratios respectively. In the color dish, add the same amount of Cu in turn 2+ , Cr 3+ , Hg 2+ ,Co 2+ , Ni 2+ , Al 3+ , Zn 2+ , Mn 2+ , Ba 2+ , Mg 2+ , Pb 2+ , Cd 2+ , Ca 2+ , Ag + and Fe 3+ , the concentration is 2.0×10 -3 mol / L, measure the fluorescence intensity values ​​respectively, and draw the fluorescence intensity histograms corresponding to different metal ions with the fluorescence intensity as the ordinate, as shown in Figure 7 shown. Other common metal ions do not interfere with the system for the determination of copper ions.

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Abstract

The invention provides a Cu<2+> chemical sensor, and a preparation method and application thereof. Based on an MOF nanomaterial, the invention combines with a Cu<2+> fluorescent probe to further prepare a Cu<2+> chemical sensor. The MOF nanomaterial ZIF-8 not only has specific adsorption capacity on Cu<2+>, but also has high porosity, high specific surface area, transition metal as center, chemical stability, regular structure, and diversified frame structure. A novel Cu<2+> sensor and fluorescent probe show good linear relationship with Cu<2+> ions, and the detection limit is 8.3*10<-9>mol / L and 5.2*10<-8>mol / L. The novel Cu<2+> sensor obtained by the present invention has a lower detection limit based on the original probe, and can be used for quantitative detection of Cu<2+> concentration the water.

Description

technical field [0001] The invention relates to the technical field of chemical sensors, in particular to a Cu sensor based on MOF (Metal-Organic Frameworks) nanomaterials 2+ Preparation methods of chemical sensors. Background technique [0002] Cu 2+ It is one of the indispensable trace elements for the human body. It helps the synthesis of hemoglobin in the organism and the maintenance of the activity of various metalloenzymes and the normal hematopoiesis of cells. Cu in cells 2+ Changes in the content can cause many serious diseases, such as: diabetes, Alzheimer's disease, muscular dystrophy, prion disease, etc. In addition, Cu in soil or drinking water 2+ Exceeding the concentration can easily cause environmental pollution and endanger human health. Therefore, a simple, sensitive, fast and accurate Cu 2+ Detection methods are of great significance to the field of biological systems and the environment. [0003] Currently used for Cu 2+ There are many detection me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06G01N21/64C08G83/00C07D213/66
CPCC07D213/66C08G83/008C09K11/06C09K2211/1029G01N21/643
Inventor 赵秀阳刘雪峰武鑫双少敏董川
Owner SHANXI UNIV
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