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Application of composition containing borneol and drug loaded nanoparticles in treatment of cerebral diseases

A drug-loading nanometer and composition technology, applied in the field of medicine, can solve problems such as brain diseases that have not yet been seen, and achieve the effects of increasing uptake, fast curative effect, and enhancing therapeutic effect.

Inactive Publication Date: 2016-08-24
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no relevant report about the combination of borneol and drug-loaded nanoparticles for the treatment of brain diseases

Method used

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  • Application of composition containing borneol and drug loaded nanoparticles in treatment of cerebral diseases
  • Application of composition containing borneol and drug loaded nanoparticles in treatment of cerebral diseases
  • Application of composition containing borneol and drug loaded nanoparticles in treatment of cerebral diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Dissolve 5 g of drug, 5 g of soybean lecithin, 5 g of cholesterol and 2 g of vitamin E in 350 mL of a mixed solution of dichloromethane and methanol at a volume ratio of 5:2, and evaporate the solvent under reduced pressure at 45 °C and 50 r / min , to obtain a dry film, evacuate at room temperature for 2 h, then dry the film with nitrogen for 20 min, add 20 mL of citric acid buffer solution with pH=5.0 to hydrate the dry film until the hydration is complete, and then use a high-shear disperser in an ice-water bath Carry out treatment (9000r / min), each shear lasts for 30 s, with an interval of 1 min, repeat 3 times, and finally freeze-dry to dry powder to obtain drug-loaded nanoparticles.

[0025] Take 5g of borneol and 50g of drug-loaded nanoparticles and mix them to make an oral preparation for treating brain glioma, cerebral apoplexy and Alzheimer's disease.

[0026] case:

[0027] The patient, male, 69 years old, had symptoms of facial paralysis, crooked right mouth ...

Embodiment 2

[0030] Mix 5g of the drug and 50g of the amphiphilic polymer material, dissolve them in 5mL of acetone solution, add dropwise to 20mL of distilled water, stir and volatilize for 30min, pour it into a dialysis bag, seal it, and place it in 500mL of distilled water , after dialysis for 24 hours, remove the formed micellar solution, pass through a 0.22 μm microporous membrane to remove insoluble drugs, and freeze-dry to dry powder;

[0031] The amphiphilic polymer material is prepared by the following method: randomly copolymerize the hydrophobic monomer methyl methacrylate and the hydrophilic monomer methacrylic acid at a molar ratio of 3:2.

[0032] Take 5g of borneol and 25g of drug-loaded nanoparticles and mix them to make an oral preparation for treating brain glioma, cerebral apoplexy and Alzheimer's disease.

[0033] case:

[0034] The patient, male, 72 years old, had symptoms of indifferent expression, unresponsiveness, speech disorder, thinking disorder, inability to ta...

Embodiment 3

[0037] Weigh 25mg of PLGA polymer, mix it and dissolve it in 500mL ethyl acetate to form the oil phase, dissolve 5mg of the drug in distilled water to obtain a 12mg / mL drug solution, and then disperse the drug solution under the condition of ultrasonic vibration in an ice-water bath Prepare colostrum in the oil phase, wherein the volume ratio of the drug solution to the oil phase is 1:5; then inject the colostrum into the poloxamer with a concentration of 10mg / mL 188 The aqueous solution forms a primary double emulsion, and finally, it is rotary evaporated at 40°C under reduced pressure until the ethyl acetate is completely volatilized, washed, and freeze-dried to obtain a dry powder.

[0038] Get borneol 5g, drug-loaded nanoparticles 80g and mix, for the treatment of brain glioma, cerebral apoplexy, Alzheimer's disease.

[0039] The patient, female, 71 years old, had symptoms of paralysis of the right limbs, inability to turn over, stiff tongue, and slurred speech.

[0040] ...

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PUM

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Abstract

The invention discloses an application of composition containing borneol and drug loaded nanoparticles in treatment of cerebral diseases. The weight ratio of the borneol to the drug loaded nanoparticles is (1-5):(5-100), and an oral preparation, an injection or nasal drops are prepared from the borneol and the drug loaded nanoparticles. Borneol can promote the drug loaded nanoparticles to cross the blood brain barrier to enter cells, so that the uptake function of the drug loaded nanoparticles in intracerebral cells is enhanced, and the drug treatment effect is enhanced.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a composition of borneol and drug-loaded nanoparticles in treating brain diseases. Background technique [0002] In recent years, the morbidity and mortality of central nervous system diseases, especially brain tumors and neurodegenerative diseases, have continued to rise. Drug transport into the central nervous system is mainly limited by the unique anatomical barrier formed by microvessels or choroid plexus. Among them, the blood-brain barrier (BBB) ​​makes it difficult for 100% of macromolecular drugs and 98% of small molecule drugs to enter the brain to exert curative effect, which seriously affects the drug treatment of brain diseases. The key to brain disease. [0003] Nano-preparation has become a research hotspot in the field of pharmaceutical preparations in recent years because of its advantages such as slow-release and targeting, and nano-preparat...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/045A61K31/704A61K9/14A61P35/00A61P25/28A61P9/10A61P25/02
CPCA61K9/145A61K9/146A61K31/045A61K31/704A61K45/06A61K2300/00
Inventor 邹亮符佳李维牛蓓杨林章津铭谭茂玲白雪雨田郭晓恒
Owner CHENGDU UNIV
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