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Pharmaceutical composition for treating damp-heat diarrhea type calf diarrhea and preparation method thereof

A technology for calf diarrhea and damp-heat diarrhea, which is applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as weak adaptability to humidity and cold, cow damage, nutritional disorders, etc., and achieve non-toxic Side effects, less recurrence, and growth-promoting effects

Inactive Publication Date: 2016-08-31
YANTAI MINWANG ELECTROMECHANICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. Caused by improper feeding and management (1) Improper cow management ① If the diet of the cow is unbalanced, not full price, and lack of exercise during pregnancy, the nutritional metabolism process of the cow will be disordered, resulting in the normal development of the fetus in the mother. Affected, newborn calves are stunted, weak in constitution, and low in resistance. In the first few days after birth, almost all of them are prone to diarrhea
Because the first-born cow has less colostrum, the milk is poor, and the concentration of immunoglobulin contained in it is low; the ability of the first-born cow to take care of the calf is poor, and the calf often cannot eat enough colostrum; the dystocia rate is high, which is harmful to the calf. Cattle have a great stress effect, and most of them need midwifery during childbirth, and there are many opportunities for human pollution
(2) Poor feeding, management and care of calves ① The calf house is too humid or the body is exposed to cold: the temperature regulation of newborn calves is not perfect, and their ability to adapt to humidity and cold is very weak, and they are most prone to dyspepsia diarrhea
②Poor sanitation has a significant impact
4. Stress caused by the immature structure and function of the digestive organs of newborn calves, poor adaptability to the external environment, so under the action of some adverse factors, such as cold, heat, noise, etc., often lead to digestive system disorders of calves, malnutrition
[0006] Western medicine generally only treats the symptoms but not the root cause, and western medicine causes certain damage to the cow itself, which is not conducive to the growth of the cow. Therefore, traditional Chinese medicine has certain advantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Mixing ratio: Magnolia officinalis 10g, Evodia 2g, Cangzhu 15g, Rock green orchid 8g, Flat rattan 12g, Half leaf 8g, Ebony 8g, Palm tree root 10g, Green bar bowl 12g, Castanopsis 8g, Red bran poplar root 10g, South Candle seed 8g, golden cherry seed 6g, gourd 10g, dodder 8g, hydrangea 8g, green green 2g, fern 12g, radix 10g, ground water 8g, mountain peony 8g, Morinda officinalis 8g, zongmu 10g, Lidan 8g and chicken tree strips 8g.

[0046] The preparation method is:

[0047] Step 1: Mix the raw medicinal materials according to the stated ratio, add 5 times the alcohol concentration of 90% ethanol to the mixture, heat to boil and reflux for 4 hours, filter, and use percolation at a rate of 2ml per minute. Percolate, collect the percolate, and then concentrate it to a paste with a relative density of 1.05 at 55°C under a vacuum of 0.08Mpa, and spray dry. The inlet air temperature of the spray dryer is 165°C and the outlet air temperature is 80°C. Crush into powder to make d...

Embodiment 2

[0050] Mixing ratio: Magnolia officinalis 20g, Evodia edulis 4g, Cangzhu 20g, Rock green orchid 15g, Flat vine 20g, Half leaf 13g, Ebony 15g, Palm tree root 15g, Green bar bowl 17g, Castanopsis 15g, Red bran poplar root 20g, South Candle seed 15g, golden cherry seed 13g, gourd 15g, dodder 15g, hydrangea 15g, green green 4g, fern 18g, radix 14g, ground water 13g, mountain peony 12g, Morinda officinalis 15g, zongmu 20g, stalk 12g and 13g of chicken tree strips.

[0051] The preparation method is:

[0052] In the first step, the raw materials are mixed in proportions, and ethanol with an alcohol concentration of 85% relative to the mass of the mixture is added, and the mixture is heated to reflux for 2 hours, extracted, and filtered to obtain the first extract; Add ethanol with an alcohol concentration of 85% that is twice the mass of the drug residue, heat to reflux for 2 hours, extract, and filter to obtain a second extract; combine the first extract with the second extract, and co...

Embodiment 3

[0056] Blending ratio: Magnolia officinalis 15g, Evodia 3g, Atractylodes 17g, Cyanlan 12g, Flat vine 17g, Half leaf 10g, Ebony 12g, Palm tree root 12g, Green bar bowl 15g, Castanopsis 12g, Red bran poplar root 15g, South Candle seed 10g, golden cherry seed 9g, gourd 12g, dodder 12g, hydrangea 10g, green green 3g, fern 15g, radix 12g, ground water 9g, mountain peony 10g, Morinda officinalis 12g, sage wood 16g, stalk 10g and chicken tree strips 10g.

[0057] The preparation method is:

[0058] In the first step, the raw medicinal materials are mixed in proportion, and ethanol with an alcohol concentration of 90% that is 3 times the mass of the mixture is added, heated to reflux for 3 hours, extracted and filtered to obtain the first extract; Add ethanol with an alcohol concentration of 90% that is twice the mass of the drug residue, heat reflux for 2 hours, extract, and filter to obtain a second extract; combine the first extract and the second extract, and concentrate under reduced...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating damp-heat diarrhea type calf diarrhea and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared from the following raw medicine materials: cortex magnoliae officinalis, fructus evodiae, radix aucklandiae, rhizoma pinelliae, rhizoma atractylodis, dracocephalum rupestra, marsdenia tenacissima, herb of Wilson passionflower, fructus mume, field opium poppy, trachycarpus root, quercus variabilis, castanopsis sclerophylla, root of R.punjabensis, asiatic bilberry, fructus rosae laevigatae, calabash, semen cuscutae, tender catchweed bedstraw herb, malachite, argentina anserina, metaplexis japonica, rhizoma dioscoreae cirrhosae, herba melastomatis dodecandri, root and bark of seguin argyreia, radix morindae officinalis, twig and leaf of tibet lyonia, orobanche coerulescens and viburnum sargenti. The pharmaceutical composition disclosed by the invention has the beneficial effects that the pharmaceutical composition is used for treating the damp-heat diarrhea type calf diarrhea and has the effects of warming middle warmer, eliminating dampness, relieving diarrhea with astringents, replenishing qi, enriching the blood, strengthening the tendons and dredging collaterals; through scientific regulation on a basal body, the effect is good, the curative effect is quickly obtained, relapse is unlikely to cause, no toxic and side effects exist, and a great promotion action on growth of calves is obtained.

Description

Technical field [0001] The invention relates to the technical field of traditional Chinese veterinary medicine, in particular to a medicinal composition for treating damp-heat diarrhea-type calf diarrhea and a preparation method thereof. Background technique [0002] Calf diarrhea, also known as calf diarrhea, can occur throughout the year, and is a gastrointestinal disease often found in calves. Calves often start to develop disease 2 to 3 days after birth, which has a great impact on the development, growth, and survival of the calf. In large groups, the incidence of calf diarrhea often reaches 90%-100%, and the mortality rate can reach more than 50%, which is a great threat to the development of the dairy industry. [0003] The occurrence of calf diarrhea is related to the conditions of fetal development and the influence of the external environment. Due to different regions and seasons, calves suffer from diarrhea. In summary, it is mainly caused by the following reasons. [...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61P1/12A61K33/34
CPCA61K36/889A61K9/146A61K33/34A61K36/185A61K36/22A61K36/27A61K36/284A61K36/35A61K36/39A61K36/42A61K36/45A61K36/53A61K36/575A61K36/64A61K36/73A61K36/736A61K36/738A61K36/74A61K36/746A61K36/754A61K36/87A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 衣文娟
Owner YANTAI MINWANG ELECTROMECHANICAL TECH CO LTD
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