Defervescence patch and preparation process thereof

Abstract

The invention discloses a defervescence patch and a preparation process thereof. The defervescence patch comprises a non-woven fabric, a hydrogel layer and a membrane isolation layer, wherein the hydrogel layer coats the non-woven fabric; the membrane isolation layer covers the hydrogel layer; the hydrogel layer is prepared from the following ingredients in percentage by weight: 0.1 to 5 percent of water-soluble cooling agents, 0.1 to 5 percent of cross-linking curing agents, 0.01 to 5 percent of stabilization softeners, 0.1 to 20 percent of thickening agents and 0.1 to 20 percent of forming agents. By adopting the mode, the defervescence patch has the advantages that irritative and allergic alcohol, two-way hygroscopic glycerinum and irritant menthol are not contained; the defervescence patch is suitable for being used by people with various allergic constitutions; the preparation process of the defervescence patch is short; the defervescence patch does not need to be dried, cured and exposed for a long time in a workshop; the bacterial virus breeding is avoided.

Description

technical field [0001] The invention relates to the field of medical products, in particular to an antipyretic patch and a preparation process thereof. Background technique [0002] People often have fever and headaches in daily life, especially children. After a fever, they often inject antipyretic injections or antibiotic injections, or often take antibiotics and hormone anti-inflammatory analgesics, which is easy to form drug dependence and increase the burden on children's liver and kidneys. , Form toxic side effects. Antipyretic plaster, as a physical cooling preparation for external application, has been approved by medical staff and loved by people. Existing antipyretic patches generally stick the antipyretic patch on the forehead, and play a cooling effect through the stimulation of the cooling sensation of the hydrogel and the process of slowly volatilizing. The antipyretic patch in the prior art is mainly composed of a non-woven fabric, a hydrogel layer, and a pl...

AI Technical Summary

Problems solved by technology

However, in the prior art, the main components of the hydrogel are insoluble menthol, peppermint oil, or insoluble cooling agents, and large doses of cosolvent glycerin, ethanol, etc. need to be added; this antipyretic patch exists The following disadvantages: (1) During the production process, due to the strong irritation of menthol, it is easy to irritate the mouth, nose and eyes of workers during production; (2) The main components of menthol and peppermint oil are insoluble in water, and fluxes and cross-linking agents need to be added. (3) The thickener sodium polyacrylate needs to add a large amount of glycerin as a dispersing emulsifier; (4) The hydrogel of this formula is not resistant to high temperature, and gradually increases with the temperature , its coolness gradually decreases until there is no coolness; and menthol is highly volatile, and the coolness time is short, only 3-5 minutes; (5) The main ingredients menthol and peppermint oil are used in large amounts, and the cooling effect is not obvious when the dosage is small (6) The hydrogel uses a large amount of highly irritating alcohol as a co-solvent, which is likely to cause allergies to children and dry skin of users; (6) Glycerin is used in large quantities as a dispersing solvent in the hydrogel, and glycerin It has extremely strong two-way hygroscopicity. In a dry environment, glycerin is easy to reverse moisture absorption, making the skin of the user of the antipyretic patch dry; and glycerin is easy to nourish the virus. The National Health and Family Planning Commission promulgated the "Human Infection with H7N9" in April 2013 In the "Avian Influenza Diagnosis and Treatment Program", it is announced that products containing glycerin are easy to nourish the virus, and it can maintain vitality for more than one year in the presence of glycerin

[0003] Moreover, in the preparation process of the antipyretic patch in the prior art, because the hydrogel layer solidifies slowly and easily flows, the hydrogel cannot be moved and bagged after application, and must be fully aired and cured for about 24 hours to 7 days. When it forms a certain stable colloid, it can be packed into bags and boxes

According to national regulations, antipyretic patches are classified as Class I medical devices that do not require purification workshops. The production environment is an ordinary workshop, and a large number of dust particles will be distributed in the air of the workshop, especially various microbial suspended particles or carry a large number of bacteria, fungi and viruses. The hydrogel layer of the antipyretic patch has a strong adhesion function. During the production process, the hydrogel layer must be fully aired for 24 hours to 7 days. Exposure to this environment is very easy to adhere and carry a large number of pathogens. Patients use it Easy to form cross-infection and repeated infection