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Povidone-iodine gynecological medical sponge and preparation method thereof

A technology of povidone-iodine and povidone, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of limited antibacterial effect and poor liquid absorption performance, and achieves long-lasting sterilization effect, high liquid absorption, and convenient placement. Effect

Active Publication Date: 2016-09-07
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its chitosan has not undergone cross-linking reaction, and its liquid absorption performance is poor, and the antibacterial effect of pure chitosan components is limited.

Method used

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  • Povidone-iodine gynecological medical sponge and preparation method thereof
  • Povidone-iodine gynecological medical sponge and preparation method thereof
  • Povidone-iodine gynecological medical sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1, the preparation of povidone-iodine gynecological medical sponge

[0043] Follow the steps below to prepare povidone-iodine gynecological medical sponge:

[0044] (1) At 25°C, add 4g of povidone K-90 and 40g of povidone-iodine solution into 100g of purified water and stir to fully dissolve until it becomes a transparent and uniform solution, then add 0.005g of glycerol glycidyl ether and stir for 30 minutes. Stand for pre-crosslinking for 18h.

[0045](2) Add 2g sodium carboxymethyl cellulose (molecular weight is 300,000), 0.2g medical polyvinyl alcohol (PVA17-99), 1g carboxymethyl chitosan with molecular weight 400,000 in the system obtained in step (1) sugar, stir evenly and foam, then put the solution in a stainless steel mold, freeze-dry for 12 hours, and sterilize the epoxy-crosslinked solution by irradiation to obtain povidone-iodine gynecological medical sponge.

[0046] Spray gold on the surface of the above-mentioned compound gynecological medica...

Embodiment 2

[0047] Embodiment 2, the preparation of composite gynecological medical sponge

[0048] Follow the steps below to prepare povidone-iodine gynecological medical sponge:

[0049] (1) At 25°C, add 4g of povidone K-90 and 50g of povidone-iodine into 100g of purified water and stir to fully dissolve until it becomes a transparent and homogeneous solution, add 0.01g of glycerol glycidyl ether, stir and mix for 30min, stand Pre-crosslinked for 18h.

[0050] (2) Add 2g sodium carboxymethylcellulose (molecular weight: 500,000), 0.2g medical polyvinyl alcohol (PVA17-88), and 1g sodium hyaluronate with a molecular weight of 700,000 to the system obtained in step (1). , stir evenly and foam, then put the solution in a silica gel mold, freeze-dry the epoxy-crosslinked solution for 24 hours, and sterilize it by irradiation to obtain povidone-iodine gynecological medical sponge.

[0051] The scanning electron micrograph of the composite gynecological medical sponge prepared in the present ...

Embodiment 3

[0052] Embodiment 3, the preparation of composite gynecological medical sponge

[0053] Follow the steps below to prepare povidone-iodine gynecological medical sponge:

[0054] (1) At 25°C, add 4g of povidone K-90 and 60g of povidone-iodine solution into 100g of purified water and stir to fully dissolve until it becomes a transparent and uniform solution, then add 0.005g of glycerol glycidyl ether and stir and mix for 30min. Stand for pre-crosslinking for 18h.

[0055] (2) Add 2g sodium carboxymethylcellulose (molecular weight is 700,000), 0.2g medical polyvinyl alcohol (PVA17-99), 1g sodium alginate with molecular weight 500,000 to the system obtained in step (1), stir uniform and foaming, then put the solution in a polytetrafluoroethylene mold, freeze-dry the epoxy cross-linked solution for 12 hours, and sterilize it by irradiation to obtain the povidone-iodine gynecological medical sponge.

[0056] The scanning electron micrograph of the composite gynecological medical sp...

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Abstract

The invention discloses povidone-iodine gynecological medical sponge and a preparation method thereof. The gynecological medical sponge is made from the following materials: povidone-iodine, sodium carboxymethyl cellulose, polyvinyl alcohol, glycerol polyglycidyl ether, water-soluble biological polysaccharides, povidone and water. The povidone-iodine gynecological medical sponge is high in liquid absorption capacity, high in physical support, good in flexibility, high in hemostatic speed, nontoxic and promotive of cell growth; in addition, the sponge is less irritating to tissues and is applicable to skin and mucous infections; the sponge has lasting significant sterilizing effect, and can remain at a focal position to provide lasting sterilization; the sponge can adjust vaginal pH and colony environment and help a human body to adjust physiological functionality; the sponge is easy to place, is auto-degradable and free of operation for removal.

Description

technical field [0001] The invention relates to a povidone-iodine gynecological medical sponge and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Cervical erosion used to be a disease that plagued many women. In 2008, the seventh edition of the "Gynecology and Obstetrics" textbook for undergraduates canceled the disease name of "cervical erosion" and replaced it with the physiological phenomenon of "cervical columnar epithelium". Cervical erosion, in the final analysis, is actually a wrong understanding of the normal performance of the cervix in the past. Cervical columnar heterotopia does not require any treatment. Many current methods of treating cervical erosion are wrong. But for symptomatic cervicitis, treatment is required. Acute inflammation is treated with suppository drugs, and chronic inflammation can be treated with physical therapy such as laser or freezing. Physical treatments such as laser freezin...

Claims

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Application Information

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IPC IPC(8): A61L15/24A61L15/28A61L15/42A61L15/46A61L15/62
CPCA61L15/225A61L15/425A61L15/46A61L15/62A61L2300/106A61L2300/404A61L2300/604C08L1/08C08L29/04C08L39/06
Inventor 赵庆凯郭刚徐秀
Owner YANTAI ZHENGHAI BIO TECH
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