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Preparation method of polygonatum odoratum polysaccharide

A polysaccharide from Polygonatum polysaccharide, Polygonatum polysaccharide technology, applied in the field of polysaccharide preparation of Polygonatum polysaccharide, can solve the problems of polysaccharide product quality instability, high protein and pigment content, high extraction temperature, etc. The effect of mild reaction conditions

Inactive Publication Date: 2016-09-07
吴迪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem mainly solved by the present invention: In the process of extracting polysaccharides from Polygonatum polysaccharides in the current traditional method, the operation is relatively cumbersome, the extraction temperature is too high, and a large amount of organic solvents are used, resulting in unstable quality of the obtained polysaccharide product, and low protein and pigment content. High current situation provides a kind of Polygonatum odoratum stem as raw material, enzymatically hydrolyzed Polygonatum odoratum enzymatic solution, placed in a centrifuge, centrifuged supernatant added ammonium sulfate, stirred and filtered to obtain filtrate, and then added to the filtrate Add activated carbon, sepiolite and D001 resin to obtain a filtrate containing Polygonatum polysaccharide, add maleic acid and ephedrine, mix and place in an ice-water bath, filter to obtain Polygonatum polysaccharide solution, distill under reduced pressure, and dry to obtain The preparation method of polygonatum polysaccharide

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020] First weigh 30g Polygonatum odoratum stems, wash them with deionized water for 3 times, then use a pulverizer to grind them, then add the pulverized Polygonatum odoratum powder into the enzymatic hydrolysis tank, and at the same time add 600mL deionized Water, 100mL pH 7.0 phosphate buffer solution, stir for 20min, then add 1g of pectinase, 2g of cellulase, 1g of hemicellulase to the enzymolysis tank, control the temperature in the enzymolysis tank to 45°C, stir for 4h After the reaction is over, raise the temperature to 100°C, heat for 20 minutes, and then cool down to room temperature to obtain the Enzymatic Hydrolyzate of Polygonatum Polygonatum; then put the Enzymatic Hydrolyzate of Polygonatum Polygonatum in a centrifuge at 6000r / min for 20min, and discard the impurities in the lower layer , to obtain the enzymolysis supernatant of Polygonatum odoratum, then add the obtained enzymolysis supernatant to the beaker, add 2g of ammonium sulfate to the beaker, stir for 10...

example 2

[0023] First, weigh 35g Polygonatum odoratum stems, wash them with deionized water for 4 times, then use a pulverizer to grind them, then add the pulverized Polygonatum odoratum powder into the enzymatic hydrolysis tank, and at the same time add 650mL deionized Water, 150mL phosphate buffer solution with a pH of 7.1, stirred for 25min, then added 2g of pectinase, 3g of cellulase, and 2g of hemicellulase to the enzymolysis tank in turn, controlled the temperature in the enzymolysis tank to 50°C, and stirred for 4.5 h, when the reaction is over, raise the temperature to 105°C, heat for 25 minutes, then cool down to room temperature to obtain Polygonatum odoratum enzymolysis solution; then put the Polygonatum odoratum enzymolysis solution in a 7000r / min centrifuge for centrifugation for 25min, discard the lower layer Impurities were obtained by enzymolysis supernatant of Polygonatum odoratum, and then the obtained enzymolysis supernatant was added to a beaker, 3g of ammonium sulfa...

example 3

[0026] First weigh 40g Polygonatum odoratum stem, wash it with deionized water for 5 times, then use a pulverizer to grind it, add the pulverized Polygonatum odoratum powder into the enzymatic hydrolysis tank, and at the same time add 700mL deionized Water, 200mL pH 7.2 phosphate buffer solution, stir for 30min, then add 3g of pectinase, 4g of cellulase, 3g of hemicellulase to the enzymolysis tank in turn, control the temperature in the enzymolysis tank to 55°C, stir for 5h After the reaction is over, raise the temperature to 110°C, heat for 30 minutes, and then cool down to room temperature to obtain Polygonatum odoratum enzymolysis solution; then put the Polygonatum odoratum enzymolysis solution in a centrifuge at 8000r / min for 30 minutes, and discard the impurities in the lower layer , to obtain the enzymolysis supernatant of Polygonatum odoratum, then add the obtained enzymolysis supernatant to the beaker, add 4g of ammonium sulfate to the beaker, stir for 20min, let stand ...

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PUM

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Abstract

The invention discloses a preparation method of polygonatum odoratum polysaccharide, and belongs to the technical field of preparation of polysaccharides. The preparation method comprises the following steps of using stem of polygonatum odoratum as raw material, and performing enzymolysis to obtain a polygonatum odoratum enzymolysis liquid; putting into a centrifugal machine, and centrifuging to obtain a supernatant; adding ammonium sulfate, stirring, and filtering, so as to obtain a filtering liquid; adding activated carbon, sepiolite and resin D001 into the filtering liquid, so as to obtain the filtering liquid containing polygonatum odoratum polysaccharide; adding maleic acid and ephedrine, mixing, putting into an ice water bath, and filtering, so as to obtain a polygonatum odoratum polysaccharide solution; performing pressure relief and distilling on the polygonatum odoratum polysaccharide solution, and drying, so as to obtain the polygonatum odoratum polysaccharide. After proofing by examples, the preparation method has the advantages that the technology is simple and convenient; the reaction condition is mild; any organic solvent is not added in the extraction process, and the defect of instable quality of polysaccharide products in the traditional technology is overcome; the yield rate of the prepared polygonatum odoratum polysaccharide is more than 35%, the purity is more than 95%, and the market prospect is broad.

Description

technical field [0001] The invention discloses a preparation method of polygonatum polysaccharide, belonging to the technical field of polysaccharide preparation. Background technique [0002] Polysaccharides have a variety of physiological functions and have extremely low cytotoxicity. Therefore, polysaccharide drugs will have broader prospects as biological response modifiers. At present, polysaccharides are isolated and prepared from natural products or fermentation products. Generally, polysaccharides are soluble in water, dilute acid, alkali or salt solution, but insoluble in alcohol, ether, acetone and other organic solvents. Solvent degreasing and depigmentation, and then extract the polysaccharide from the residue with water-based solution, that is, extract with cold water, hot water, dilute acid, alkali or salt solution. After the extract is concentrated, first use trichloroacetic acid, trifluorotrichloroethane The method or Sevag method is used to remove impuriti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P3/10A61P3/06
CPCC08B37/0051A61K31/715A61K36/8969A61K2236/19A61K2236/331A61K2236/53C08B37/0003C08B37/0066
Inventor 吴迪张明孟浩影
Owner 吴迪