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Preparation method of color-developing medical dressing

A chromogenic agent and nanoparticle technology, which is applied in the field of chromogenic medical dressings and its preparation, can solve problems such as human organ damage, cell damage, and bacterial reproduction that cannot be observed by the naked eye, so as to prevent further deterioration, prevent failure, quickly identify and indication effect

Inactive Publication Date: 2016-10-12
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, silver ions have obvious cytotoxicity. While killing bacteria, they also have certain damage to normal cells of the human body. Some organs are damaged; chitosan dressing belongs to animal-derived dressings. In recent years, chitosan dressing allergies have occurred frequently, which has seriously affected the clinical use of chitosan dressings
[0005] The reproduction of bacteria cannot be observed by the naked eye, and the reproduction speed is very fast. Once the wound is infected with bacteria, symptoms such as redness, swelling, itching, and pus will appear on the wound, which seriously affects the healing of the wound

Method used

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  • Preparation method of color-developing medical dressing
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  • Preparation method of color-developing medical dressing

Examples

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Effect test

Embodiment 1

[0032] A method for preparing a color-developing medical dressing, characterized in that, the specific steps of the preparation method are as follows:

[0033] (1) Dissolve 0.5g red tetrazolium in 100mL deionized water to prepare a red tetrazolium solution with a mass percentage of 0.5%; the specific surface area of ​​1g is 1300 m 2 / g, mesoporous silica nanoparticle powder with a particle size of 0.1nm was added to the red tetrazolium solution, sealed with aluminum foil, stirred magnetically for 24 hours at 25°C, washed with distilled water, and centrifuged three times to remove excess red tetrazolium. tetrazole, obtain red tetrazole / mesoporous silicon dioxide nanoparticle powder, dry for subsequent use;

[0034] (2) After mixing 1.0g sodium alginate and 1.0g sodium carboxymethylcellulose evenly, dissolve them completely in 100mL distilled water to prepare a sodium alginate / sodium carboxymethylcellulose gel with a mass percentage of 2%;

[0035](3) Add 0.5 g of the sodium al...

Embodiment 2

[0038] A method for preparing a color-developing medical dressing, characterized in that, the specific steps of the preparation method are as follows:

[0039] (1) Dissolve 2.5g red tetrazolium in 100mL deionized water to prepare a red tetrazolium solution with a mass percentage of 2.5%; the specific surface area of ​​5 g is 1600 m 2 / g, mesoporous silica nanoparticle powder with a particle size of 5nm was added to the red tetrazolium solution, and sealed with aluminum foil, stirred magnetically for 24 hours at 25°C, washed with distilled water, and centrifuged 3 times to remove excess red tetrazolium Azole, to obtain red tetrazole / mesoporous silica nanoparticle powder, drying for subsequent use;

[0040] (2) After mixing 2.5 g sodium alginate and 2.5 g sodium carboxymethyl cellulose, they were completely dissolved in 100 mL distilled water to prepare a 5% sodium alginate / sodium carboxymethyl cellulose gel;

[0041] (3) In the sodium alginate / sodium carboxymethylcellulose gel...

Embodiment 3

[0044] A method for preparing a color-developing medical dressing, characterized in that, the specific steps of the preparation method are as follows:

[0045] (1) Dissolve 5g of red tetrazolium in 100mL of deionized water to prepare a red tetrazolium solution with a mass percentage of 5%; 2 / g, mesoporous silica nanoparticle powder with a particle size of 10nm was added to the red tetrazolium solution, and sealed with aluminum foil, magnetically stirred at 25°C for 24h, washed with distilled water, and centrifuged 3 times to remove excess red tetrazolium Azole, to obtain red tetrazole / mesoporous silica nanoparticle powder, drying for subsequent use;

[0046] (2) After mixing 4g of sodium alginate and 4g of sodium carboxymethylcellulose evenly, they were completely dissolved in 100mL of distilled water to prepare a sodium alginate / sodium carboxymethylcellulose gel with a mass percentage of 8%;

[0047] (3) In the sodium alginate / sodium carboxymethyl cellulose gel prepared in ...

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Abstract

The invention belongs to the field of medical dressings, and particularly relates to color-developing medical dressing and a preparation method thereof. The preparation method comprises the following steps: taking TTC (Triphenyl Tetrazolium Chloride) as a color developing agent, mesoporous silica nanoparticles as a carrier and alginate and sodium carboxymethyl cellulose as spinning raw materials, preparing fiber containing color developing components through electrostatic spinning, and then preparing the fiber into the medical dressing containing the color developing components through a non-woven fabric technology. The color-developing medical dressing prepared by the preparation method has very good biological safety, and has an indicating function on a bacteria-infected wound; meanwhile, the color-developing medical dressing has very good liquid absorptivity, and is capable of absorbing leakage liquid of the wound and promoting the healing of the wound.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a color-developing medical dressing and a preparation method thereof. Background technique [0002] Red tetrazolium, also known as 2,3,5-triphenyl tetrazolium chloride, or TTC for short, is a commonly used bacterial chromogen and is widely used in microbial testing. Red tetrazolium is a white or colorless crystalline powdery substance, which is easily reduced and can be reduced to a red insoluble pigment (triphenylmethane) by the succinate dehydrogenase produced in the metabolic process of bacteria to appear red. The red pigment is relatively stable, will not be automatically oxidized by oxygen in the air, and can play a long-lasting color development effect. However, triphenylformazan has a certain stimulating effect on the skin and eyes and cannot be in direct contact with the skin. Applying red tetrazolium to medical dressings has not been reported at present. [0003] Mesop...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/20A61L15/18A61L15/42A61L15/56
CPCA61L15/28A61L15/18A61L15/20A61L15/42A61L15/56A61L2300/442C08L5/04C08L1/286
Inventor 卢亢庄壮辉韦加娜李婷
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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