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A polyurethane/small intestinal submucosa (pu/sis) two-component injectable hydrogel

A technology for injecting water into the submucosa of the small intestine, which is applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problems of large and small trauma, and achieve the effect of extremely surgical trauma, small surgical trauma, and good clinical application prospects.

Active Publication Date: 2019-08-16
TOPREGMED BEIJING MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a polyurethane / small intestinal submucosa (PU / SIS) injectable hydrogel material, which can repair wounds through endoscopy, with small trauma, and solve the problem that existing repair materials must be repaired by open surgery And there is a problem of trauma

Method used

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  • A polyurethane/small intestinal submucosa (pu/sis) two-component injectable hydrogel
  • A polyurethane/small intestinal submucosa (pu/sis) two-component injectable hydrogel
  • A polyurethane/small intestinal submucosa (pu/sis) two-component injectable hydrogel

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Experimental program
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Effect test

Embodiment 1

[0087] Embodiment 1 Preparation of injectable gel product box of the present invention

[0088] (1) Preparation method

[0089] Preparation of Component A:

[0090] Add 0.26mol lysine diisocyanate and 0.19mol polyε-caprolactone diol 1000 into a four-neck three-neck bottle, pass condensed water during the reaction, and adjust the rotation speed of the stirring rod to 800-1000r / m. Under nitrogen protection, dimethylethanolamine (3 drops) as the catalyst, polymerize for 4 hours at a temperature of 75°C, then add 0.02mol small molecule chain extender ethylene glycol and 0.03mol hydrophilic chain extender DMPA, and cool down to 50°C , continue to reflect for 3 to 4 hours, and use acetone to adjust the viscosity during the reaction (after adding the chain extender, add acetone to adjust the viscosity of the system every 1 hour, 8ml each time). Configure 1000mL of 0.04mol / L triethylamine solution, disperse the polyurethane polymer in the triethylamine solution under rapid shear con...

Embodiment 2

[0108] Embodiment 2 Preparation of injectable gel product box of the present invention

[0109] (1) Preparation method

[0110] Preparation of Component A:

[0111] Add 0.27 mol of isophorone diisocyanate and 0.15 mol of polytetrahydrofuran ether 1000 into a four-necked three-neck flask, pass condensed water during the reaction, adjust the stirring speed to 800-1000 r / m, add 2 drops of stannous octoate catalyst, Pre-polymerize at 75°C for 2 hours under the protection of nitrogen, then cool down to 55°C, add 0.04mol small molecule chain extender 1,4-butanediol and 0.05mol hydrophilic chain extender 2,2-hydroxymethylpropionic acid ( DMPA), and continue the chain extension reaction for 3 to 4 hours. During the reaction process, acetone can be added to adjust the viscosity of the reaction system (after adding the chain extender, add acetone to adjust the viscosity of the system every 1h, the amount added each time is 8mL), so that the reaction can be maintained in a steady state...

Embodiment 3

[0121] Embodiment 3 Preparation of injectable gel product box of the present invention

[0122] (1) Preparation method

[0123] Preparation of Component A:

[0124] Add 0.27 mol of isophorone diisocyanate and 0.15 mol of polyε-polycaprolactone diol 2000 into a four-neck three-necked bottle, pass condensed water during the reaction, and adjust the rotation speed of the stirring rod to 800-1000 r / m. Under the protection of nitrogen, dibutyltin diacetate (2 drops) was used as the catalyst to polymerize for 4 hours at a temperature of 75 ° C, and then 0.07 mol of hydrophilic chain extender dimethylol propionic acid (2,2-dimethylolpropionic acid was added) acid), lower the temperature of the system to 50°C, and continue the reaction for 3 to 4 hours. During the reaction, an appropriate amount of acetone was used to adjust the viscosity (after adding the chain extender, acetone was added every 1 h to adjust the viscosity of the system, 8 mL each time). Configure 1200mL of 0.08mol...

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Abstract

The invention discloses a two-component injectable hydrogel product box, which comprises two components stored separately: component A is a polyurethane emulsion, and component B is a sol containing small intestinal submucosa powder and acetic acid. The present invention also provides the preparation method and application of the aforementioned product box. The two components in the hydrogel product package of the present invention can be mediated by endoscopic technology to realize injection and implantation, and can quickly gel in situ and be fixed on the damaged part, which has a good repair effect on the wound surface, and surgical trauma It is extremely small, and provides a new option for minimally invasive repair and prevention of complications of muscular luminal tissue injury, and has a good clinical application prospect.

Description

technical field [0001] The invention relates to a polyurethane / small intestinal submucosa (PU / SIS) two-component injectable hydrogel. Background technique [0002] Since the 20th century, with the overall development of medical science, more and more research results have been applied to the diagnosis and treatment of diseases. Therefore, the etiology, pathogenesis, diagnosis, treatment and even prevention of some major diseases have been achieved in the past 100 years. Significant progress has been made. Especially in recent years, the rapid development of new technologies of digestive endoscopy has played a revolutionary role in the diagnosis and treatment of digestive system diseases. In addition to conventional gastroscopy and colonoscopy, there are now miniature endoscopes such as laparoscopy, thoracoscopy, ventriculoscopy, arthroscopy, and intervertebral disc laparoscopy. It is widely used in gastroenterology, hepatobiliary surgery, chest, obstetrics and gynecology, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/42A61L15/26A61L15/40
CPCA61L15/26A61L15/40A61L15/42
Inventor 解慧琪龚梅
Owner TOPREGMED BEIJING MEDICAL TECH CO LTD
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