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Composite drug-loading fiber for surgical sutures

A surgical suture and drug-loading technology, applied in the directions of surgery, fibrous chemical characteristics, cellulose/protein conjugated rayon, etc. release performance

Inactive Publication Date: 2016-10-12
YANCHENG INST OF IND TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to relieve the lack of varieties of existing surgical sutures, most of which can only meet the basic needs of suture, such as rough surface, easy swelling, easy adhesion, easy deformation, easy to cause secondary damage, easy to infection, etc. A series of problems, it is necessary to develop new varieties with good biocompatibility, antibacterial and mechanical properties to make up for the defects and deficiencies of existing varieties

Method used

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  • Composite drug-loading fiber for surgical sutures
  • Composite drug-loading fiber for surgical sutures
  • Composite drug-loading fiber for surgical sutures

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of Bacterial Cellulose A and Chitin B Solid Content A: (A+B) = 50% (w / w), Cellulose Microcrystalline C: (A+B) = 1% (w / w), Ciprosa Star D: (A+B)=1% (w / w) a composite drug-loaded fiber for surgical sutures and its preparation method:

[0032] Step (1): Solvent selection and dissolution of bacterial cellulose, chitin, cellulose microcrystals, and ciprofloxacin respectively.

[0033] Dissolve the bacterial cellulose with DMAc / LiCl mixed solvent system, place the bacterial cellulose in a freeze dryer at -50°C for 2 to 3 days, take it out and crush it, impregnate 2 g of freeze-dried bacterial cellulose in 98 g of 6 %(w / w) LiCl mixed solvent system of DMAc / LiCl, stirred and swelled at a speed of 50-100 rpm at room temperature, dissolved for 2 days until fully dissolved, and bacterial cellulose spinning with a solid content of 2% (w / w) was obtained. silk liquid;

[0034] Chitin was dissolved in DMAc / LiCl mixed solvent system, weighed 2 g chitin and placed in 98 g ...

Embodiment 2

[0041] Preparation of Bacterial Cellulose A and Chitin B Solid Content A: (A+B) = 10% (w / w), Cellulose Microcrystalline C: (A+B) = 2% (w / w), Ciprosa Star D: (A+B)=2% (w / w) a composite drug-loaded fiber for surgical sutures and its preparation method:

[0042] Step (1): Solvent selection and dissolution of bacterial cellulose, chitin, cellulose microcrystals, and ciprofloxacin respectively.

[0043] Weigh 3 g of freeze-dried bacterial cellulose and impregnate it in 97 g of DMAc / LiCl mixed solvent system containing 7% (w / w) LiCl, stir and swell at room temperature at a speed of 50-100 rpm, and dissolve for 2 days until fully dissolved. A bacterial cellulose spinning solution with a solid content of 3% was obtained; 3 g of chitin was weighed and placed in 97 g of DMAc / LiCl solvent containing 7% (w / w) LiCl, and the solid content was obtained according to the treatment method in Example 1. The content is 3% chitin spinning solution; the preparation of 10% cellulose microcrystallin...

Embodiment 3

[0047] Preparation of bacterial cellulose A and chitin B solid content A: (A+B) = 30% (w / w), cellulose microcrystalline C: (A+B) = 1% (w / w), ciprosa Star D: (A+B)=1% (w / w) a composite drug-loaded fiber for surgical sutures and its preparation method:

[0048] Step (1): Solvent selection and dissolution of bacterial cellulose, chitin, cellulose microcrystals, and ciprofloxacin respectively.

[0049] Weigh 2.5 g of freeze-dried bacterial cellulose and impregnate it in 97.5 g of DMAc / LiCl mixed solvent system containing 8% (w / w) LiCl, stir and swell at room temperature at a speed of 50-100 rpm, and dissolve for 2 days until fully dissolved. Obtain a bacterial cellulose spinning solution with a solid content of 2.5% (w / w); weigh 2.5 g of chitin and place it in 97.5 g of DMAc / LiCl solvent containing 8% (w / w) LiCl, according to Example 1 The treatment method was to obtain a chitin spinning solution with a solid content of 2.5%; the preparation of the 10% cellulose microcrystalline ...

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Abstract

The invention provides a novel composite material for surgical sutures prepared by adopting a wet spinning technique, namely a bacterial cellulose / chitin / cellulose microcrystalline / ciprofloxacin composite drug-loading fiber. Bacterial cellulose and chitin are biomaterials having good biocompatibility, cellulose microcrystalline is an excellent reinforced material, ciprofloxacin is an excellent spectral antibacterial drug. On the one hand, the composite spun fiber prepared by compounding and mixing the four components in a certain proportion and according to a specific sequence can prevent microbe breeding caused by the bacterial cellulose in the applying process; on the other hand, the shortcomings of large hardness, low strength and poor toughness of purely spun chitin fibers can be also overcome. The bacterial cellulose / chitin / cellulose microcrystalline / ciprofloxacin composite fiber integrates the advantages of the four materials, has excellent antibacterial properties, good strength, ductility and toughness, has a good and uniform fiber surface structure and has good sustained drug release performance, the fiber diameter is about 30 microns, and the drug release time can be up to more than 10 days.

Description

technical field [0001] The invention relates to a composite drug-loaded fiber used for surgical sutures and a preparation method thereof, belonging to the technical field of new materials. Background technique [0002] At present, there are few varieties of surgical sutures, and most of them can only meet the basic needs of sutures. There are a series of problems such as rough surface, easy swelling, easy adhesion, easy deformation, easy to cause secondary damage, easy to infect, etc. Therefore, it is necessary to develop some New varieties with good biocompatibility, antibacterial and mechanical properties can make up for the defects and deficiencies of existing varieties. [0003] Both chitin and bacterial cellulose solution have certain rheological properties and filamentous properties, and are good fiber-forming materials. Fibers with high strength and elongation can be produced through conventional wet spinning processes. Preliminary studies have found that chitin fibe...

Claims

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Application Information

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IPC IPC(8): D01F8/02D01F1/10D01D5/06D01D1/02A61L17/10
CPCA61L17/005A61L17/10A61L2300/216A61L2300/404D01D1/02D01D5/06D01F1/103D01F8/02
Inventor 吴焕岭周彬陈贵翠王岚朱迅
Owner YANCHENG INST OF IND TECH
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