Method for treating avermectin oil

A technology of abamectin and processing method, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve problems such as difficult handling and storage of abamectin ointment, and reduce unsafe factors , increase the content, improve the effect of benefit

Active Publication Date: 2016-10-26
HEBEI XINGBAI AGRI SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is exactly to provide a kind of processing method of abamectin ointment, to solve the problem that abamectin ointment is difficult to handle and store

Method used

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  • Method for treating avermectin oil
  • Method for treating avermectin oil
  • Method for treating avermectin oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Get 110g Abamectin ointment, detect that its contained B1a composition is 5.06%; Add 200g methylene chloride in Abamectin ointment, be warming up to 50 ℃, stir, and Abamectin ointment is dissolved completely, A homogeneous solution was obtained; the resulting solution was cooled to 5° C., and 300 g of petroleum ether was added, and stirred. After crystallization began, the stirring was continued for 1 h to obtain a crystal slurry; the obtained crystal slurry was filtered under normal temperature to obtain 93 g of powder. Use HPLC to detect and analyze the powder and filtrate. The chromatographic detection conditions are: mobile phase (methanol: acetonitrile: water=38:38:24), wavelength (UV=245nm), chromatographic column (Zorbax C-18 4.6*150mm ), the pressure is 64bar, the test results are shown in Table 1 and attached figure 1 .

[0036] Table 1:

[0037]

[0038] Abamectin standard sample spectrum such as figure 2 and shown in Table 2.

[0039] Table 2:

[00...

Embodiment 2

[0046] Get 1kg Abamectin Ointment, and detect that the contained B1a active ingredient is 5.06%; add 1kg bromoethane to Abamectin Ointment, heat up to 40°C, stir, and Abamectin Ointment is completely dissolved , to obtain a homogeneous solution; the resulting solution was cooled to 5 ° C, and 2 kg of n-pentane and n-hexane (miscible in any ratio) were added, stirred, and after the crystallization began, continued stirring for 1 h to obtain a crystal slurry; the obtained crystal slurry was filtered by suction , to obtain 0.91kg powder. The powder is detected and analyzed by HPLC, and the detection results are shown in Table 4 and image 3 .

[0047] Table 4:

[0048]

[0049] Abamectin B1a standard sample is used to calculate the absolute content of B1a in the powder by external standard method in Table 5.

[0050] table 5:

[0051]

[0052] The yield of abamectin B1a in the crystalline powder is 96.6%.

Embodiment 3

[0054] Get 113.2g of Abamectin ointment, and detect that the contained B1a component is 5.06%; add 80g of dichloropropane to Abamectin ointment, heat up to 50°C, stir, and make Abamectin ointment dissolve completely , to obtain a homogeneous solution; the resulting solution was cooled to 5 ° C, and 80 g of n-hexane was added, stirred, and after the crystallization began, the stirring was continued for 1 h to obtain a crystal slurry; the obtained crystal slurry was filtered under normal temperature to obtain 90 g of powder. Use HPLC to detect and analyze the powder, and the chromatographic detection conditions are: mobile phase (acetonitrile: water=80: 20), wavelength (UV=245nm), chromatographic column (Zorbax C-18 4.6*150mm), pressure is 53bar, FLOW=1.0ml / min test results are shown in Table 6 and Figure 5 :

[0055] Table 6

[0056]

[0057] Abamectin B1a standard sample is used to calculate the absolute content of B1a in the powder by external standard method in Table 7...

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Abstract

The invention provides a method for treating avermectin oil. The method comprises the following steps: a, a halogenated hydrocarbon solvent is added to the avermectin oil, the obtained solution is stirred at the temperature of 30-70 DEG C to dissolve the avermectin oil, and a homogeneous solution is obtained; b, the solution is cooled to 5-0 DEG C, a solventing-out agent is added and stirred, stirring is continued for 1-2 h after crystallization, and crystallized slurry is obtained, wherein the solventing-out agent is an alkane solventing-out agent; c, the crystallized slurry is subjected to suction filtration or centrifugal separation at normal temperature, and effective ingredient powder of avermectin is obtained. Almost all the effective ingredient B1a in the avermectin oil is extracted with a solventing-out crystallization method, the yield is as high as 96%, meanwhile, the avermectin oil is changed into powder from original oil which is difficult to treat and store, the problem that the avermectin oil is difficult to store is solved, harm or possible harm of the environment and crops caused by the avermectin oil is avoided, vendible oil prepared from toxic solvents such as toluene and the like is avoided, and safety and environment friendliness are realized.

Description

technical field [0001] The invention relates to a method for extracting residual biologically active antibiotic components from antibiotic waste, in particular to a treatment method for abamectin ointment. Background technique [0002] Abamectin, the English name Avermectins, is a natural fermentation component of Streptomyces. It is a class of sixteen-element antibiotics with insecticidal, acaricidal and nematicidal activities first developed by Satoshi Omura of Kitasato University in Japan and Merck Company of the United States. Cyclic lactone compounds, which have 8 different structures, are A1a, A1b, A2a, A2b, B1a, B1b, B2a and B2b respectively, forming 4 pairs of homologues. Among them, A1a, A2a, B1a and B2a have higher activity, and among them, B1a has the strongest biological activity. [0003] The structural formula of Abamectin is: [0004] [0005] In the formula, R of different structures of avermectins 1 Group, X-Y and R 2 The groups are shown in the table...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/08C07H1/06
CPCC07H1/06C07H17/08
Inventor 王琳慧鲁森聂会敏郭军杰
Owner HEBEI XINGBAI AGRI SCI & TECH CO LTD
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