The invention discloses a process for preparing spicy bitter gourds pickled with vinegar, belonging to the technical field of food processing. The process is characterized by adopting 30kg of fresh bitter gourds, 5kg of green peppers, 5kg of red peppers, 8kg of vinegar, 1.5kg of coriander, 2kg of onions, 1.2kg of liquorice root and 1.2kg of salt as raw materials and comprises the following main steps: raw material selection, pretreatment, salting, putting in jars and pickling. The process has the beneficial effects that the preparation process is simple, is lower in raw material and processing equipment costs and is convenient to implement; the products are rich in nutrients, taste fragrant and crisp, slightly taste bitter, have the peculiar fragrant flavors of bitter gourds, are beneficial to improving the body resistance, can achieve the effects of promoting diet, diminishing inflammation and abating fever, also have the functions of preventing and resisting cancers and reducing blood sugar, can serve as good products for food therapy for patients with obesity, diabetes mellitus, cardiovascular diseases and cancers, can also serve as health care food for the general population to prevent similar diseases, and are green and healthy health maintenance food suitable for people of all ages.