Preparation method of medical degradable magnesium alloy provided with calcium phosphate coating

Abstract

The invention discloses a preparation method of a medical degradable magnesium alloy provided with calcium phosphate coating, and belongs to the field of medical alloy preparation. The preparation method comprises the steps as follows: firstly, pig bones are cooked and then mildew naturally; then the pig bones are crushed and mixed with mold, calcium in the pig bones is dissolved by acid substances in orange peel and lemon peel through catalysis with enzyme in the mold body as a catalyst, a reaction with an ammonium phosphate solution is performed under the conditions of alkalescence and heating; lower precipitate for standby application is used for promoting a crystallization behavior in an aging process, obtained crystals are calcined, and a coating powder material is obtained; the coating powder material is deposited on the magnesium alloy surface activated with hydrofluoric acid, and the medical biodegradable calcium phosphate coating magnesium alloy is prepared. The medical degradable magnesium alloy, supplemented by calcium in the pig bones as the coating material, has good compatibility with human tissue without immunological rejection; after coating treatment, the degradation speed of the magnesium alloy in the human body is decreased, and the degradation product calcium salt capable of being absorbed by the human body as a nutrient for tissue regeneration, so that patients recover ahead of time.

Description

technical field [0001] The invention discloses a preparation method of a medical degradable calcium phosphate-coated magnesium alloy, which belongs to the field of medical alloy preparation. Background technique [0002] With the rapid increase of social population, the continuous improvement of living standards, the emergence of a large number of vehicles, the accelerated pace of life, frequent accidental injuries such as traffic accidents and sports trauma, fractures and bone defects often occur. In the process of bone tissue repair, it is sometimes necessary to implant tissue repair materials in the human body to assist the growth and healing of injured tissue. Metal materials, ceramic materials and organic polymer materials have all been applied in artificial hard tissue materials. Among them, metal materials include stainless steel, titanium-based alloys, and cobalt-based alloys. Due to their high strength, good toughness, and chemical stability, they are widely used i...

AI Technical Summary

Problems solved by technology

[0006] The technical problem mainly solved by the present invention: Aiming at the occurrence of traditional medical magnesium alloys in the process of use, as a hard tissue substitute material, the degradation rate is too fast in the physiological environment, and the degradation products will change the pH value around the tissue and affect the surrounding tissue cells. For the problem of growth, a preparation method of medical degradable calcium phosphate-coated magnesium alloy is provided. In the present invention, firstly, the pork bone is steamed and molded naturally, then crushed and mixed with mold, and then the enzyme in the mold is used as a catalyst to catalyze orange The acidic substance in the peel and lemon peel dissolves the calcium in the pig bone, reacts with the ammonium phosphate solution under weak alkaline and heating conditions, and then uses the sediment in the lower layer to promote the crystallization behavior during the aging process, and then calcines the obtained crystals to obtain Coating powder material is deposited on the surface of magnesium alloy activated by hydrofluoric acid by electrophoresis to prepare medical degradable calcium phosphate coated magnesium alloy