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Compound preparation for treating vertebra osteomyelitis and preparation method of compound preparation

A technology of compound preparation and osteomyelitis, which is applied in the field of compound preparation for the treatment of spinal osteomyelitis and its preparation, which can solve the problems of high treatment cost, large side effects, and long course of treatment, and achieve the restoration of vitality of human organs, safety, small side effects, and anti-inflammatory effect strong effect

Inactive Publication Date: 2016-11-16
孙鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of vertebral osteomyelitis is mostly anti-osteomyelitis drug therapy and surgical treatment, but the anti-osteomyelitis drug therapy has the disadvantages of large side effects, slow effect, and long course of treatment; although surgical treatment is effective, it has high risks and high treatment costs. high disadvantage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: This embodiment provides a tablet of a compound preparation for the treatment of vertebral osteomyelitis, including the following ingredients in parts by weight: 3 parts of amikacin, 5 parts of diacerein, 15 parts of aureus, 21 parts of eleutheroside, 34 parts of acetaminophen glucoside, 21 parts of active protein peptide, 26 parts of chitosan, 1 part of trace elements, 15 parts of vitamin D, 0.3 parts of preservatives, 4 parts of disintegrants, diluted 132 doses.

[0020] Wherein, the paracetamol glucoside uses bromoglucose and p-nitrophenol as raw materials, uses acetic anhydride and bromine gas as catalysts at 60°C, and adds 1.1 times the amount of hydrogen peroxide relative to p-nitrophenol Sodium uses phase transfer catalytic synthesis to synthesize p-nitrophenyl tetraacetyl glucoside, and then catalyzes reduction to amino tetraacetyl glucoside at 20°C with 5% Pd-C, and then acylates it under the catalysis of acetic anhydride to obtain For acetaminop...

Embodiment 2

[0028] Embodiment 2: This embodiment provides a tablet of a compound preparation for treating vertebral osteomyelitis, including the following ingredients in parts by weight: 4 parts of amikacin, 7 parts of diacerein, 20.5 parts of aureus, 26.5 parts of eleutheroside, 36 parts of acetaminophen glucoside, 27 parts of active protein peptide, 36.5 parts of chitosan, 1.5 parts of trace elements, 19 parts of vitamin D, 0.4 parts of preservatives, 5.5 parts of disintegrants, diluted 159.5 parts of the agent.

[0029] Wherein, the paracetamol glucoside is based on bromoglucose and p-nitrophenol as raw materials, and acetic anhydride and bromine gas are used as catalysts at 60-90°C, and 1.2 times the amount of p-nitrophenol is added Sodium hydroxide synthesizes p-nitrophenyltetraacetylglucoside by phase-transfer catalytic synthesis method, and then catalyzes reduction to aminotetraacetylglucoside at 30°C with 5% Pd-C, and then acyls it under the catalysis of acetic anhydride. To obta...

Embodiment 3

[0037] Embodiment 3: This embodiment provides a tablet of a compound preparation for treating vertebral osteomyelitis, including the following ingredients in parts by weight: 5 parts of amikacin, 9 parts of diacerein, 26 parts of aureus, 32 parts of eleutheroside, 38 parts of acetaminophen glucoside, 33 parts of active protein peptide, 47 parts of chitosan, 2 parts of trace elements, 23 parts of vitamin D, 0.5 parts of preservatives, 7 parts of disintegrants, diluted 187 doses.

[0038] Wherein, the paracetamol glucoside uses bromoglucose and p-nitrophenol as raw materials, uses acetic anhydride and bromine gas as catalysts at 90°C, and adds 1.3 times the amount of hydrogen peroxide relative to p-nitrophenol Sodium uses phase transfer catalytic synthesis to synthesize p-nitrophenyl tetraacetyl glucoside, and then catalyzes reduction to amino tetraacetyl glucoside at 40°C with 5% Pd-C, and then acylates it under the catalysis of acetic anhydride to obtain For acetaminophen tet...

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Abstract

The invention discloses a compound preparation for treating vertebra osteomyelitis and a preparation method of the compound preparation. The compound preparation consists of the following ingredients: amikacin, diacerein, onychin, eleutheroside, paracetamol glucoside, active protein peptide, chitosan, trace elements, vitamin D, methyl salicylate, arbutin, algae polysaccharide, tramadol hydrochloride, radix dipsaci alkali and gypenoside. The compound preparation for treating the vertebra osteomyelitis disclosed by the invention has functions of relieving pain, resisting inflammation and killing bacteria, and the compound preparation is capable of promoting blood circulation, promoting development of bones and strengthening tendons and bones; moreover, the compound preparation is capable of relieving apoptosis, enhancing resistance of organs and improving human metabolism; and clinical application verifies that the compound preparation is significant in curative effect on the vertebra osteomyelitis, and the compound preparation is safe and low in side effects.

Description

technical field [0001] The invention relates to the technical field of orthopedic drugs, in particular to a compound preparation for treating vertebral osteomyelitis and a preparation method thereof. Background technique [0002] Osteomyelitis of the spine is a common intractable disease in orthopedic clinics. With the development of modern industry, there are more and more osteomyelitis, followed by osteomyelitis of the spine. Most osteomyelitis is often caused by acute osteomyelitis It develops from improper treatment or untimely treatment. Osteomyelitis of the spine is mostly caused by bacteremia. The primary purulent lesions are more common in the genitourinary system. skin and respiratory tract. in the skeletal system. The incidence of spinal infection is low. It accounts for about 1% to 4% of systemic bone infections. Osteomyelitis of the spine is often accompanied by disc inflammation. Paravertebral soft tissue inflammation. Even paravertebral abscesses. Easy...

Claims

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Application Information

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IPC IPC(8): A61K31/7036A61K31/222A61K31/7048A61K31/7034A61K31/722A61K31/59A61K31/618A61K31/715A61K31/137A61K31/704A61K33/06A61K33/30A61K38/00A61P19/08
CPCA61K31/137A61K31/222A61K31/59A61K31/618A61K31/7034A61K31/7036A61K31/704A61K31/7048A61K31/715A61K31/722A61K33/06A61K33/30A61K38/00A61K2300/00
Inventor 孙鹏
Owner 孙鹏
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