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Florescent silicon oxide nanoparticle preparation method

A technology of nano-particles and silicon oxide, applied in chemical instruments and methods, nanotechnology, nano-optics, etc., can solve the problems of expensive raw materials, weak luminous intensity, poisonous and flammable, etc. The effect of uniform size distribution

Inactive Publication Date: 2016-11-16
高大元
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention: the raw materials in the preparation process of traditional fluorescent silicon oxide nanoparticles are expensive, toxic and flammable, and the product particles and the half-peak width of the fluorescence spectrum are relatively large, and the luminous intensity is weak and scattered. Poor performance, which is unfavorable to the current situation of application in biological multicolor fluorescence imaging, provides a kind of quartz sand as raw material, made of silica and then nano-sized to make nano-silicon dioxide, and then the prepared nano-silicon Silicon dioxide and hydrofluoric acid form silicon fluoride, and then react with sodium aluminum hydride to produce silane gas, then use lycopene and fluorescein isothiocyanate to gasify and mix with silane gas, add hydrogen peroxide and place in a strong magnetic field Electric field reaction, thereby obtaining the preparation method of fluorescent silicon oxide nanoparticles

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] First, weigh 10g of quartz sand for pulverization, pass through a 100-mesh sieve, collect the quartz sand powder, pour it into a beaker containing 300mL of deionized water, and oscillate with 180W ultrasound for 10 minutes, where the mass concentration of 10mL is added during the ultrasonic oscillation. 0.5mol / L hydrochloric acid solution, stirred and reacted for 20min, then the reaction solution was filtered, the residue was removed, and washed with deionized water three times to obtain silica; then the silica obtained above was added to the 100mL mass In a beaker with a concentration of 0.5 mol / L NaOH solution, stir and react for 1 hour to obtain a sodium silicate solution, then add 100 mL of a hydrochloric acid solution with a mass concentration of 1 mol / L to the obtained sodium silicate solution, stir and react for 1 hour, filter, and use After washing with deionized water for 3 times, as for calcination in a muffle furnace at 700°C for 4 hours, and natural cooling to...

example 2

[0025] First, weigh 15g of quartz sand for pulverization, pass through a 150-mesh sieve, collect the quartz sand powder, pour it into a beaker containing 350mL of deionized water, and oscillate with 190W ultrasonic for 15min, in which 15mL is added in the process of ultrasonic oscillation. 0.5mol / L hydrochloric acid solution, stirred and reacted for 25min, then the reaction solution was filtered, the residue was removed, and it was washed with deionized water 4 times to obtain silica; then the silica obtained above was added to the 150mL mass In a beaker with a concentration of 0.5 mol / L NaOH solution, stir and react for 1.5 hours to obtain a sodium silicate solution, then add 150 mL of a hydrochloric acid solution with a mass concentration of 1 mol / L to the obtained sodium silicate solution, stir and react for 1.5 hours, filter, After the filter residue was washed 4 times with deionized water, it was calcined in a muffle furnace at 750°C for 5 hours and cooled to room temperatu...

example 3

[0028] First, weigh 20g of quartz sand for pulverization, pass a 200-mesh sieve, collect the quartz sand powder, pour it into a beaker containing 400mL of deionized water, and oscillate it with 200W ultrasonic for 20min, where 20mL is added during the ultrasonic oscillation process. 0.5mol / L hydrochloric acid solution, stirred and reacted for 30min, then the reaction solution was filtered, the residue was removed, and it was washed repeatedly with deionized water 5 times to obtain silica; then the silica obtained above was added to the 200mL mass In a beaker with a concentration of 0.5 mol / L NaOH solution, stir and react for 2 hours to obtain a sodium silicate solution, then add 200 mL of a hydrochloric acid solution with a mass concentration of 1 mol / L to the obtained sodium silicate solution, stir and react for 2 hours, filter, and use After washing with deionized water for 5 times, as for calcination in a muffle furnace at 800°C for 6 hours, and natural cooling to room temper...

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Abstract

The invention discloses a method for preparing fluorescent silicon oxide nanoparticles, which belongs to the technical field of silicon oxide particles. In the present invention, quartz sand is used as raw material to make silicon dioxide through nanometerization to make nano-silicon dioxide, and then the prepared nano-silicon dioxide and hydrofluoric acid form silicon fluoride, and then react with sodium aluminum hydride , to produce silane gas, and then use lycopene and fluorescein isothiocyanate to vaporize and mix with silane gas, add hydrogen peroxide and place it in a strong magnetic field for reaction, so as to obtain fluorescent silicon oxide nanoparticles. Examples prove that the present invention is safe to operate. By gasifying lycopene and fluorescein isothiocyanate extracted from tomatoes, it is environmentally friendly and at the same time enhances the fluorescence of fluorescent silicon oxide nanoparticles. In addition, hydrogen peroxide is added and placed in a strong magnetic field reaction, forming free radicals to generate corona, improving stability, and the prepared fluorescent silica nanoparticles have extremely narrow half-width of fluorescence spectrum, strong luminosity, and can be applied on a large scale.

Description

Technical field [0001] The invention discloses a method for preparing fluorescent silicon oxide nanoparticles, which belongs to the technical field of silicon oxide particles. Background technique [0002] Immunoassays are increasingly used in the detection of biomarkers, bacteria and viruses. The nanomarkers used in immunoassays largely determine the sensitivity and specificity of the analysis. Various types of nanoparticles that have been developed, including colloidal gold, carbon black, upconversion fluorescent nanoparticles, quantum dots, liposomes, etc., have shown excellent immunoassay effects. However, these nanomarkers still have their own shortcomings. For colloidal gold, carbon black markers, etc., they only rely on particle aggregation to generate optical signals, and thus exhibit low sensitivity in immunochromatography. Although the later developed fluorescent nano-labels greatly improved the sensitivity of immunoassays, they also have some drawbacks. For example,...

Claims

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Application Information

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IPC IPC(8): C09K11/59B82Y20/00C07C7/00C07C11/21
CPCC09K11/592B82Y20/00C07C7/005
Inventor 高大元张明孟浩影
Owner 高大元
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