Preparation method of adriamycin nano-drug particles

A nano-drug, doxorubicin technology, applied in the direction of medical formula, drug combination, making the drug into a special physical or taking form of the device, etc., can solve the problem of poor stability of nano-powder, wide particle size distribution range, preparation process, etc. Complicated problems, to achieve the effect of narrow particle size distribution, improved dissolution rate, and avoiding local supersaturation

Inactive Publication Date: 2017-01-04
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the common problems of these methods are complex preparation process, high production cost, large particle size, and wide particle size distribution range. More importantly, due to the large specific surface area and high surface energy of nanoparticles, they are easy to dissolve in liquid. Agglomeration occurs in the phase medium, resulting in poor stability of the obtained nanopowder

Method used

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  • Preparation method of adriamycin nano-drug particles
  • Preparation method of adriamycin nano-drug particles
  • Preparation method of adriamycin nano-drug particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The reaction apparatus used is as figure 1 As shown, the filler layer 2 is an ordinary wire mesh.

[0043] Weigh 100 mg of doxorubicin hydrochloride, dissolve it in 40 mL of dimethyl sulfoxide at room temperature, add 40 μL of triethylamine to remove hydrochloric acid, react for 5 min, and add 100 mg of Poloxamer 188, stirred to make it fully dissolved, and placed in the storage tank 9 as the solvent phase. Measure 400 mL of pure water and place it in the storage tank 10 as the anti-solvent phase. Turn on the digital display frequency regulator controlling the motor 3 to 20Hz (1150rpm). Adjust the flow meter 5, set the flow rate of the solvent phase to 30mL / min, and the flow rate of the anti-solvent phase to 300mL / min, that is, the ratio of the solvent to the anti-solvent is 1:10. Start the motor 3, and when the number displayed on the frequency regulator rises from 0 to 20Hz and displays stably for 10s, the two feed liquids are sent out by the pump 8, and sprayed on...

Embodiment 2

[0046] The reaction apparatus that adopts is identical with embodiment 1.

[0047] Weigh 100 mg of doxorubicin hydrochloride, dissolve it in 40 mL of dimethyl sulfoxide at room temperature, add 40 μL of triethylamine to remove hydrochloric acid, react for 5 min, and add 100 mg of Poloxamer 188 , stirred to make it fully dissolved, and placed in the storage tank 9 as the solvent phase. Measure 400 mL of pure water and place it in the storage tank 10 as the anti-solvent phase. Turn on the digital display frequency regulator controlling the motor 3 to 30Hz (1730rpm). Adjust the flow meter 5, set the flow rate of the solvent phase to 30mL / min, and the flow rate of the anti-solvent phase to 300mL / min, that is, the ratio of the solvent to the anti-solvent is 1:10. Start the motor 3, and when the number displayed on the frequency regulator rises from 0 to 30Hz and displays stably for 10s, the two feed liquids are sent out by the pump 8, and sprayed on the inner edge of the rotating...

Embodiment 3

[0050] The reaction apparatus that adopts is identical with embodiment 1.

[0051] Weigh 100 mg of doxorubicin hydrochloride, dissolve it in 40 mL of dimethyl sulfoxide at room temperature, add 40 μL of triethylamine to remove hydrochloric acid, react for 5 min, and add 100 mg of Poloxamer 188 , stirred to make it fully dissolved, and placed in the storage tank 9 as the solvent phase. Measure 400 mL of pure water and place it in the storage tank 10 as the anti-solvent phase. Turn on the digital display frequency regulator controlling the motor 3 to 40Hz (2300rpm). Adjust the flow meter 5, set the flow rate of the solvent phase to 30mL / min, and the flow rate of the anti-solvent phase to 300mL / min, that is, the ratio of the solvent to the anti-solvent is 1:10. Start the motor 3, and when the number displayed on the frequency regulator rises from 0 to 40Hz and displays stably for 10s, the two feed liquids are sent out by the pump 8, and sprayed on the inner edge of the rotating...

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Abstract

The invention discloses a preparation method of adriamycin nano-drug particles, belongs to the field of drug preparation and provides an adriamycin containing solution and a proper anti-solvent. The adriamycin containing solution and the anti-solvent are put in a first storage tank for a drug solution and a second storage tank for the anti-solvent; the two kinds of liquid are conveyed out through a pump, flow through a flowmeter, enter a supergravity reactor at the same time and are sprayed to the rotating inner edge of a packing layer, so that adriamycin is recrystallized out through an anti-solvent precipitation crystallization method; adriamycin suspension liquid is collected, and adriamycin nano-drug powder is obtained after dialysis and freeze-drying. By the adoption of the method, the nanoscale adriamycin drug particles with a controllable average particle size and narrow particle size distribution can be obtained by using different surfactants, regulating the volume flow ratio of the two kinds of liquid, changing motor frequency and the like.

Description

technical field [0001] The invention belongs to the field of medicine preparation, in particular to a preparation method of doxorubicin nano drug particles. Background technique [0002] Doxorubicin is an anthracycline antineoplastic drug that acts on DNA. It can enter the nucleus through the tumor cell membrane and intercalate DNA. It is commonly used to treat leukemia, Hodgkin's lymphoma, and some cancers of the bladder, breast, stomach, lung, ovary, thyroid, soft tissue sarcoma, and multiple myeloma. Doxorubicin has the molecular formula C 27 h 29 NO 11 , whose structure is as follows: [0003] [0004] Nanomedicine technology is an emerging technology in the pharmaceutical industry and a hot spot in current drug research. At the nanoscale, drugs and drug carriers exhibit new properties. Preparation of poorly water-soluble drugs into nanoparticles can increase the specific surface area of ​​the particles, improve their solubility, reduce the amount of co-solvent,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/704A61P35/00A61J3/02
CPCA61K9/19A61J3/02A61K31/704
Inventor 张建军宋晓庆王洁欣陈建峰
Owner BEIJING UNIV OF CHEM TECH
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