Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Thermo-sensitive type composite hydrogel and preparation method thereof

A composite hydrogel, temperature-sensitive technology, used in pharmaceutical formulations, medical science, prostheses, etc., can solve the problems of complete non-toxicity, good rupture strength and biocompatibility, and achieve good biocompatibility. Good properties, good gel-forming properties and good application prospects

Inactive Publication Date: 2017-01-04
林春梅
View PDF5 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing temperature-sensitive hydrogels cannot meet the requirements of biomedical applications such as complete non-toxicity, anti-rupture strength, and good biocompatibility.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A temperature-sensitive composite hydrogel, prepared from the following raw materials in parts by weight: 30 parts of N-isopropylacrylamide, 12 parts of valine, 3 parts of tyrosine, 1 part of polyvinylpyrrolidone, glycine-rich 3 parts of maleate, 2 parts of polyethylene glycol, 0.5 parts of ferulic acid, 0.2 parts of chitosan oligosaccharide, 1 part of zinc powder, 0.6 parts of carboxymethyl cellulose, 0.3 parts of sodium metabisulfite, 0.8 parts of oxalic acid, dithiothreo 2 parts of sugar alcohol, 2 parts of potassium persulfate, 3 parts of calcium glycerophosphate, 2 parts of konjac glucomannan, 20 parts of glycerin, 0.2 parts of potassium chloride, 70 parts of deionized water.

[0024] The preparation method of the temperature-sensitive composite hydrogel comprises the following preparation steps:

[0025] 1) Add chitosan oligosaccharide, zinc powder, polyethylene glycol and oxalic acid to 3 / 4 total weight of deionized water, stir evenly, then add ferulic acid and c...

Embodiment 2

[0032] A temperature-sensitive composite hydrogel prepared from the following raw materials in parts by weight: 60 parts of N-isopropylacrylamide, 20 parts of valine, 8 parts of tyrosine, 4 parts of polyvinylpyrrolidone, glycine-rich 7 parts of maleate, 6 parts of polyethylene glycol, 4 parts of ferulic acid, 2 parts of chitosan oligosaccharide, 3 parts of zinc powder, 4 parts of carboxymethyl cellulose, 2 parts of sodium metabisulfite, 1.5 parts of oxalic acid, dithiothreo 6 parts of sugar alcohol, 7 parts of potassium persulfate, 8 parts of calcium glycerophosphate, 7 parts of konjac glucomannan, 36 parts of glycerin, 2 parts of potassium chloride, 150 parts of deionized water.

[0033] The preparation method of the temperature-sensitive composite hydrogel comprises the following preparation steps:

[0034] 1) Add chitosan oligosaccharide, zinc powder, polyethylene glycol and oxalic acid into 3 / 4 total weight of deionized water, stir evenly, then add ferulic acid and continu...

Embodiment 3

[0041] A temperature-sensitive composite hydrogel prepared from the following raw materials in parts by weight: 34 parts of N-isopropylacrylamide, 13 parts of valine, 4 parts of tyrosine, 1.2 parts of polyvinylpyrrolidone, glycine-rich 3.5 parts of maleate, 2.5 parts of polyethylene glycol, 0.8 parts of ferulic acid, 0.4 parts of chitosan oligosaccharide, 1.2 parts of zinc powder, 0.8 parts of carboxymethyl cellulose, 0.5 parts of sodium pyrosulfite, 0.9 parts of oxalic acid, dithiothreo 2.5 parts of sugar alcohol, 2.2 parts of potassium persulfate, 3.6 parts of calcium glycerophosphate, 2.8 parts of konjac glucomannan, 27 parts of glycerin, 0.3 parts of potassium chloride, 92 parts of deionized water.

[0042] The preparation method of the temperature-sensitive composite hydrogel comprises the following preparation steps:

[0043] 1) Add chitosan oligosaccharide, zinc powder, polyethylene glycol and oxalic acid into 3 / 4 total weight of deionized water, stir evenly, then add f...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Bursting strengthaaaaaaaaaa
Login to View More

Abstract

The invention provides thermo-sensitive type composite hydrogel and a preparation method thereof. The thermo-sensitive type composite hydrogel is prepared from the following raw materials: N-isopropyl acrylamide, valine, tyrosine, polyvinylpyrrolidone, glycine fumarate, polyethylene glycol, ferulic acid, chitosan oligosaccharide, zinc powder, carboxymethyl cellulose, sodium metabisulfite, oxalic acid, dithiothreitol, potassium peroxodisulfate, calcium glycerophosphate, konjac glucomannan, glycerol, potassium chloride and deionized water. The thermo-sensitive type composite hydrogel provided by the invention is good in gelling properties at physiological temperature, free of allergenicity, good in biocompatibility, good in rupture strength, not easy to damage, stable in properties and good in application prospects, the cytotoxicity of the thermo-sensitive type composite hydrogel is lower than grade I, and various performance indexes are all at relatively high levels.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a temperature-sensitive composite hydrogel and a preparation method thereof. Background technique [0002] As a biocompatible material, hydrogel is mainly used in medicine for anti-adhesion after surgery, hemostatic agent, filling of defective tissue, preventing interstitial fluid leakage, and slow release of drugs. According to the different responses of hydrogels to external stimuli, they can be divided into traditional hydrogels and smart hydrogels. Among them, smart hydrogels are very sensitive to changes in the external environment, such as external temperature, pH, photoelectric signals, chemical molecules, etc. When small changes occur, the hydrogel itself can undergo corresponding physical or chemical structural changes, so the application range of smart hydrogels is wider. [0003] Smart hydrogels can be divided into temperature-sensitive hydrogels, photo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08F291/06C08F291/08C08F220/54C08F2/44C08K13/02C08K3/08C08K5/053C08K3/16C08J3/075A61L27/02A61L27/04A61L27/16A61L27/18A61L27/20A61L27/52A61L27/54A61L31/02A61L31/04A61L31/06A61L31/14A61L31/16C08L51/02C08L51/08
CPCC08F251/00A61L27/025A61L27/04A61L27/16A61L27/18A61L27/20A61L27/52A61L27/54A61L31/022A61L31/028A61L31/042A61L31/048A61L31/06A61L31/145A61L31/16A61L2400/04C08F251/02C08F271/00C08F283/06C08J3/075C08J2351/02C08J2451/08C08K3/08C08K3/16C08K5/053C08K13/02C08K2003/0893C08F220/54C08L51/003C08L51/08C08L51/02
Inventor 林春梅
Owner 林春梅
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com