Thermo-sensitive type composite hydrogel and preparation method thereof

A composite hydrogel, temperature-sensitive technology, used in pharmaceutical formulations, medical science, prostheses, etc., can solve the problems of complete non-toxicity, good rupture strength and biocompatibility, and achieve good biocompatibility. Good properties, good gel-forming properties and good application prospects

Inactive Publication Date: 2017-01-04
林春梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing temperature-sensitive hydrogels cannot meet the requirements of biomedical applications such as complete non-toxicity, anti-rupture strength, and good biocompatibility.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A temperature-sensitive composite hydrogel, prepared from the following raw materials in parts by weight: 30 parts of N-isopropylacrylamide, 12 parts of valine, 3 parts of tyrosine, 1 part of polyvinylpyrrolidone, glycine-rich 3 parts of maleate, 2 parts of polyethylene glycol, 0.5 parts of ferulic acid, 0.2 parts of chitosan oligosaccharide, 1 part of zinc powder, 0.6 parts of carboxymethyl cellulose, 0.3 parts of sodium metabisulfite, 0.8 parts of oxalic acid, dithiothreo 2 parts of sugar alcohol, 2 parts of potassium persulfate, 3 parts of calcium glycerophosphate, 2 parts of konjac glucomannan, 20 parts of glycerin, 0.2 parts of potassium chloride, 70 parts of deionized water.

[0024] The preparation method of the temperature-sensitive composite hydrogel comprises the following preparation steps:

[0025] 1) Add chitosan oligosaccharide, zinc powder, polyethylene glycol and oxalic acid to 3 / 4 total weight of deionized water, stir evenly, then add ferulic acid and c...

Embodiment 2

[0032] A temperature-sensitive composite hydrogel prepared from the following raw materials in parts by weight: 60 parts of N-isopropylacrylamide, 20 parts of valine, 8 parts of tyrosine, 4 parts of polyvinylpyrrolidone, glycine-rich 7 parts of maleate, 6 parts of polyethylene glycol, 4 parts of ferulic acid, 2 parts of chitosan oligosaccharide, 3 parts of zinc powder, 4 parts of carboxymethyl cellulose, 2 parts of sodium metabisulfite, 1.5 parts of oxalic acid, dithiothreo 6 parts of sugar alcohol, 7 parts of potassium persulfate, 8 parts of calcium glycerophosphate, 7 parts of konjac glucomannan, 36 parts of glycerin, 2 parts of potassium chloride, 150 parts of deionized water.

[0033] The preparation method of the temperature-sensitive composite hydrogel comprises the following preparation steps:

[0034] 1) Add chitosan oligosaccharide, zinc powder, polyethylene glycol and oxalic acid into 3 / 4 total weight of deionized water, stir evenly, then add ferulic acid and continu...

Embodiment 3

[0041] A temperature-sensitive composite hydrogel prepared from the following raw materials in parts by weight: 34 parts of N-isopropylacrylamide, 13 parts of valine, 4 parts of tyrosine, 1.2 parts of polyvinylpyrrolidone, glycine-rich 3.5 parts of maleate, 2.5 parts of polyethylene glycol, 0.8 parts of ferulic acid, 0.4 parts of chitosan oligosaccharide, 1.2 parts of zinc powder, 0.8 parts of carboxymethyl cellulose, 0.5 parts of sodium pyrosulfite, 0.9 parts of oxalic acid, dithiothreo 2.5 parts of sugar alcohol, 2.2 parts of potassium persulfate, 3.6 parts of calcium glycerophosphate, 2.8 parts of konjac glucomannan, 27 parts of glycerin, 0.3 parts of potassium chloride, 92 parts of deionized water.

[0042] The preparation method of the temperature-sensitive composite hydrogel comprises the following preparation steps:

[0043] 1) Add chitosan oligosaccharide, zinc powder, polyethylene glycol and oxalic acid into 3 / 4 total weight of deionized water, stir evenly, then add f...

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Abstract

The invention provides thermo-sensitive type composite hydrogel and a preparation method thereof. The thermo-sensitive type composite hydrogel is prepared from the following raw materials: N-isopropyl acrylamide, valine, tyrosine, polyvinylpyrrolidone, glycine fumarate, polyethylene glycol, ferulic acid, chitosan oligosaccharide, zinc powder, carboxymethyl cellulose, sodium metabisulfite, oxalic acid, dithiothreitol, potassium peroxodisulfate, calcium glycerophosphate, konjac glucomannan, glycerol, potassium chloride and deionized water. The thermo-sensitive type composite hydrogel provided by the invention is good in gelling properties at physiological temperature, free of allergenicity, good in biocompatibility, good in rupture strength, not easy to damage, stable in properties and good in application prospects, the cytotoxicity of the thermo-sensitive type composite hydrogel is lower than grade I, and various performance indexes are all at relatively high levels.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a temperature-sensitive composite hydrogel and a preparation method thereof. Background technique [0002] As a biocompatible material, hydrogel is mainly used in medicine for anti-adhesion after surgery, hemostatic agent, filling of defective tissue, preventing interstitial fluid leakage, and slow release of drugs. According to the different responses of hydrogels to external stimuli, they can be divided into traditional hydrogels and smart hydrogels. Among them, smart hydrogels are very sensitive to changes in the external environment, such as external temperature, pH, photoelectric signals, chemical molecules, etc. When small changes occur, the hydrogel itself can undergo corresponding physical or chemical structural changes, so the application range of smart hydrogels is wider. [0003] Smart hydrogels can be divided into temperature-sensitive hydrogels, photo...

Claims

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Application Information

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IPC IPC(8): C08F291/06C08F291/08C08F220/54C08F2/44C08K13/02C08K3/08C08K5/053C08K3/16C08J3/075A61L27/02A61L27/04A61L27/16A61L27/18A61L27/20A61L27/52A61L27/54A61L31/02A61L31/04A61L31/06A61L31/14A61L31/16C08L51/02C08L51/08
CPCC08F251/00A61L27/025A61L27/04A61L27/16A61L27/18A61L27/20A61L27/52A61L27/54A61L31/022A61L31/028A61L31/042A61L31/048A61L31/06A61L31/145A61L31/16A61L2400/04C08F251/02C08F271/00C08F283/06C08J3/075C08J2351/02C08J2451/08C08K3/08C08K3/16C08K5/053C08K13/02C08K2003/0893C08F220/54C08L51/003C08L51/08C08L51/02
Inventor 林春梅
Owner 林春梅
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