Preparation method and application of rhodiola rosea and coffee extract

A Rhodiola rosea and extract technology, which is applied in the direction of food ingredients, applications, and food extraction containing natural extracts, can solve the problems of unacceptable strong bitter taste, difficult to accurately grasp the amount of additives, and limited breadth and other problems

Inactive Publication Date: 2017-02-15
TONGHUA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of application, the strong bitterness and astringency naturally possessed by Rhodiola rosea make it difficult for the audience to accept, which limits its wide application
In order to overcome this fatal defect in the practical application of Rhodiola rosea, chemical food additives are usually used to remove tannins from Rhodiola rosea, such as "a method of removing tannins in salidroside extracts by using cyclodextrin embedding technology." Method" (Patent Publication No.: CN104083426A), "Research on the Method of Removing Tanning of Rhodiola Extract Powder" ("West China Pharmaceutical Journal" 2000, 15) uses gelatin to remove tannin to improve the astringent taste. The disadvantage of this type of method is that it must be Additives are used to achieve the purpose. As Rhodiola is a natural product, the tannins contained in each batch are different during the processing process, so it is difficult to accurately control the amount of additives added. When the corresponding impurities are introduced, many medicinal ingredients will be removed. , does not conform to the current international trend of green safety

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Properly crush 1000g of Rhodiola rosea raw material, add pre-purchased commercial coffee powder with a weight ratio of 1:1, mix well, add 20 times of water, extract twice at 100°C for 2 hours each time, filter, and combine to extract liquid, adding a flocculant to remove impurities, and concentrating to obtain the extract of rhodiola rosea and coffee. The concentration temperature is 20° C., and the specific gravity of rhodiola rosea and coffee is 1.1-1.2.

[0013] Weigh 50g of the extract extract, add 50g of microcrystalline cellulose to make the extract, add 25g of mannitol, stir evenly, put it in an oven to dry at 100°C-120°C, grind, and the fine powder after grinding is very fine Sieve, add 15g of rock sugar fine powder, spray appropriate amount of ethanol, knead the fine powder into agglomerates, disperse after pressing, sieve, dry the fine powder in an oven at 50°C after sieving, and press into tablets to obtain oral disintegration Tablets.

Embodiment 2

[0015] Properly pulverize 1000g of Rhodiola rosea raw material, add pre-purchased commercial coffee powder with a weight ratio of 1:1, mix well, add 20 times of water (in addition to water as the ideal solvent, you can also choose the commonly used conventional existing technology. Adaptive replacement with other solvents), extracting twice at 100°C for 2 hours each time, filtering, combining the extracts, adding flocculant to remove impurities, and concentrating to obtain the extracts of Rhodiola rosea and coffee. The concentration temperature is 20°C, and the ratio of rhodiola rosea to coffee is 1.1-1.2.

[0016] Take 50g of the above extract, 90% ethanol as a wetting agent, add excipients at a ratio of soluble starch: dextrin 7:1, the amount of excipients: the main ingredient is 0.5:1, and the drying temperature is 50°C. Granules and whole granules can be obtained as oral granules.

Embodiment 3

[0018] Properly crush 1000g of Rhodiola rosea raw material, add pre-purchased commercial coffee powder with a weight ratio of 1:1, mix well, add 20 times of water, extract twice at 100°C for 2 hours each time, filter, and combine to extract liquid, add flocculant to remove impurities, and concentrate to obtain the extract of rhodiola rosea and coffee.

[0019] Take 50g of the above-mentioned extract, take another 25g of powdered sugar, 5ml of fructose syrup, 10g of milk powder, appropriate amount of paraben, and 150ml of distilled water, dissolve and remove impurities to obtain an oral liquid.

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PUM

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Abstract

The invention discloses a preparation method and an application of a rhodiola rosea and coffee extract. The preparation method comprises the following steps: properly grinding and mixing rhodiola rosea and coffee; extracting the rhodiola rosea and the coffee for 2-3 times with the addition of a solvent which is 10-30 times the total weight of the rhodiola rosea and the coffee at 50-250 DEG C, wherein each time lasts for 1-3h; and filtering and combining extracting solutions, removing an insoluble precipitate and recovering the solvent, so as to obtain the rhodiola rosea and coffee extract. The invention provides the application of the extract in preparing drugs and functional health care foods; and the drugs can be represented in the dosage forms of tablets, capsules, granules, a mixture, pills or water pills.

Description

technical field [0001] The invention relates to the preparation and application of a traditional Chinese medicine extract, in particular to the preparation and application of a rhodiola rosea extract. Background technique [0002] Rhodiola is a perennial herb or subshrub plant. There are more than 90 kinds of original plants in the world, and there are more than 70 kinds in my country. It is mainly produced in the Changbai Mountain area of ​​Jilin, Tibet, and Sichuan. It is born in the forests of hillsides, gravel hillsides and alpine tundra at an altitude of 1600-2500 meters. North Korea, Japan, and the Far East of the Soviet Union are also distributed. Rhodiola is a traditional Chinese medicine in my country. Rhodiola crenulata (HK. f. et.Thoms) H. Ohba is recorded in the 2010 edition of "Chinese Pharmacopoeia", which has the functions of nourishing qi, promoting blood circulation, Tongmai calming It can be used for qi deficiency and blood stasis, chest obstruction and he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A23L33/105A61L33/00
CPCA23V2002/00A61K36/41A61K36/74A61K2300/00A23V2250/21A23V2250/2108A23V2300/14
Inventor 薛长松夏广清刘欢刘伟宋金枝卢香凝左吉卉范丽颖赵国华邱久文魏凤云
Owner TONGHUA NORMAL UNIV
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