Mers-cov specific polypeptide and its application

A specific, MHC-I technology, applied in the field of immunoassay
CN106397549BActive Publication Date: 2019-08-06STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
Publication Date
2019-08-06

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Abstract

The invention discloses MERS-CoV specific polypeptides and application thereof, belongs to the field of immunodetection and provides three MERS-CoV specific polypeptides aiming at BABL / c mice. An MHC-tetramer is prepared by using corresponding polypeptides, affinity between polypeptide-MHC and specific T cell surface TCR is improved effectively, and the MHC-tetramer can serve as an effective tool for T cell evaluation. The technology can be used for separating and cloning of specific T cells and performing in-situ dyeing on mouse corresponding tissue slices after MERS-CoV infection or vaccination and has high application value in the studying aspect of T cells of a mouse model after MERS-CoV infection or vaccination.
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Description

technical field

[0001] The invention relates to a MERS-CoV specific polypeptide and an application thereof, and belongs to the field of immune detection. Background technique

[0002] In June 2012, the first case of MERS was found in Saudi Arabia. Subsequently, more cases were reported in the Arabian Peninsula and spread to Asia, Africa, Europe and North America. The mortality rate was as high as 35.7%. In July 2015, There is also an imported case of infection in our country. The development of safe and effective vaccines is one of the important means to control the spread of MERS-CoV. T cells play a very important role in virus clearance. In the evaluation of the immune effect of MERS-CoV vaccine, the evaluation of T cell immune response is particularly important. The establishment of a susceptible mouse model of MERS-CoV provides a good animal model for the development of its vaccine. It is particularly important to develop efficient, rapid, and sensitive detection meth...

Claims

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