Preparation method of magnesium glycinate chelate

A magnesium glycinate and chelate technology, which is applied in the field of preparation of magnesium glycinate chelate, can solve problems such as adverse reactions and difficult absorption, and achieve the effects of increasing biological potency, reducing reaction time, and promoting absorption

Inactive Publication Date: 2017-03-08
HEBEI DONGHUA JIHENG CHEM
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the magnesium-supplementing drugs used by the human body are mainly inorganic salts, which will bring a large amount of interfering anions (sulfate, etc.) into the body. Such drugs are not easily absorbed by the human body, and will also cause adverse reactions

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  • Preparation method of magnesium glycinate chelate

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preparation example Construction

[0025] A kind of preparation method of magnesium glycinate chelate, preparation method comprises the following steps:

[0026] ①Synthesis reaction: Put glycine, magnesium compound and water into the reaction kettle according to the reaction molar ratio of 2:1.05:11.1~2:1.8:16.7, stir and mix, heat to 50~90℃, react for 1~6 hours, The reaction solution is obtained, the magnesium compound is one or more of magnesium oxide, magnesium hydroxide, magnesium acetate, magnesium carbonate, basic magnesium carbonate, and the water used is deionized water;

[0027] ②Purification of the product: filter the reaction solution at 60°-70° to obtain the filtrate and filter residue, and then carry out alcohol analysis on the filtrate. The alcohol used is any one of methanol, ethanol, ethylene glycol or propanol. The alcohol used and The volume ratio of filtrate is 1:2~1:4. ; After standing for 2 to 6 hours, centrifuge, and the speed of centrifugation is 2000 to 2500 rpm to obtain alcohol and pr...

Embodiment 1

[0031] Take 150Kg (about 2 kilomoles) of glycine, 63.8Kg (about 1.1 kilomoles) of magnesium hydroxide and 125Kg of deionized water, put the raw materials into the reaction kettle, stir and mix, heat to 80°C, and react for 4 hours to obtain the reaction liquid; filter the reaction solution while it is hot (at a temperature of 70°C) to obtain the filtrate and filter residue, then add 375 liters of ethanol to the filtrate for alcohol analysis, and after standing for 4 hours, carry out the centrifuge at a speed of 2000 rpm. Centrifuge to obtain alcohol separation liquid and precipitate, and dry the precipitate at 105° C. for 2 hours to obtain 187.2 kg of magnesium glycinate chelate product, with a yield of 97.5%. After testing, the magnesium content of the product is 11.8%. The ethanol solution was rectified at 85°C for 4 hours to obtain 367 liters of ethanol, and the remainder was rectification liquid. The ethanol was recovered and reused for alcohol analysis. The rectification li...

Embodiment 2

[0033] Take 75Kg (about 1 kilomole) of raw material glycine, 22.4Kg (about 0.56 kilomole) of magnesium oxide and 150Kg deionized water, put the raw materials into the reaction kettle, stir and mix, heat to 70°C, and react for 4 hours to obtain the reaction liquid ; Filtrate the reaction solution while it is hot (at a temperature of 60°C) to obtain the filtrate and filter residue, then add 300 liters of propanol to the filtrate for alcohol analysis, and after standing for 4 hours, proceed under the condition of a centrifuge speed of 2200 rpm Centrifuge to obtain alcohol separation liquid and precipitate, and dry the precipitate at 85° C. for 3 hours to obtain 164.2 kg of magnesium glycinate chelate product, with a yield of 85.1%. After testing, the magnesium content of the product is 9.8%. The ethanol separation liquid was rectified at 85°C for 3 hours to obtain 292 liters of propanol, and the rest was rectification still liquid. The propanol was recovered and reused for alcohol...

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Abstract

The invention discloses a preparation method of a magnesium glycinate chelate. The preparation method comprises the following steps: (1) synthesis reaction: adding glycine, a magnesium compound and water into a reaction kettle according to a ratio, stirring and mixing the raw materials, heating the mixture to a reaction temperature, allowing the mixture to react for a period of time to obtain a reaction solution, (2) purification of the product: filtering the reaction liquid at a certain temperature to obtain a filtrate and a filter residue; carrying out alcohol precipitation treatment on the filtrate, allowing the filtrate to stand for a period of time, and then centrifugally separating the filtrate to obtain alcohol precipitation solution and precipitate; drying the precipitate to obtain the magnesium glycinate chelate product; (3) post-treatment: rectifying the alcohol precipitation solution, and reusing the alcohol obtained after rectification to the alcohol precipitation treatment step; and returning the distillation residue after rectification and the filter residue to the reaction kettle for reuse. The invention provides the preparation method of the magnesium glycinate chelate without interference ions, and three wastes are prevented.

Description

technical field [0001] The invention relates to the technical field of magnesium supplement preparations, in particular to a preparation method of a magnesium glycinate chelate. Background technique [0002] Magnesium is one of the most abundant cations in human cells, and it is also an important substance that regulates the balance of calcium, sodium and potassium ions inside and outside cells; it catalyzes and activates a variety of enzyme reactions in the body, and participates in almost all energy metabolism processes in the body and the synthesis of DNA, RNA, etc. Because magnesium ions are related to the energy production of cells, they can treat chronic fatigue syndrome and senile dementia, quickly restore physical strength, and improve intelligence; when magnesium ions are used together with iron and calcium ions, they can be used to treat anemia, osteoporosis loose disease etc. At the same time, there are 0.05% magnesium ions in animals, which not only maintain the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/18C07C227/40C07C229/08
CPCC07C227/18C07C227/40
Inventor 王秀茹冯辉曾著飞徐志伟赵红梅宋铁犇马宁宁韩素娟张明路张雄飞魏马立李欢
Owner HEBEI DONGHUA JIHENG CHEM
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