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A polymer fluorescence sensor capable of ratiometric detection of hypochlorous acid and its application

A fluorescent sensor and a technology for detecting hypochlorous acid, applied in fluorescence/phosphorescence, instruments, measuring devices, etc., can solve the problems of reduced feasibility and limited applicability, and achieve convenient post-processing, obvious selectivity, fast response, and sensitivity high effect

Active Publication Date: 2018-09-14
HUNAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when it comes to small molecule sensors, its unique defects cannot be ignored. First, most small molecule sensors work in pure organic solvents or mixed solvents, because the biological toxicity of organic solvents limits its applicability; secondly, Small molecule sensors can aggregate in water due to π-π interactions with each other, further limiting applicability
This also leads to a reduction in the feasibility of using this type of sensor in actual detection.

Method used

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  • A polymer fluorescence sensor capable of ratiometric detection of hypochlorous acid and its application
  • A polymer fluorescence sensor capable of ratiometric detection of hypochlorous acid and its application
  • A polymer fluorescence sensor capable of ratiometric detection of hypochlorous acid and its application

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Effect test

Embodiment 1

[0029]Embodiment 1: the preparation of a kind of fluorescent sensor that can ratio detect hypochlorous acid, concrete steps are as follows:

[0030] (1) Dissolve 4-bromo-1,8-naphthalene dianhydride (10 mmol) and 4-(2-aminoethyl)morpholine (10 mmol) in ethylene glycol methyl ether (10 mL), placed in N 2 Under the conditions of protection and avoiding light, rapidly raise the temperature to 120°C and stir for 4 hours. After the reaction is completed, it is directly added to 40 mL of distilled water to precipitate, and the desired product is obtained by suction filtration, and vacuum-dried to obtain product 1;

[0031] (2) Dissolve the product 1 (3 mmol) synthesized in step (1) in 10 mL of ethylenediamine, and place the mixed solution in the dark and N 2 Stir at 80°C for 4 h under protected conditions, remove most (85-95%) of ethylene glycol methyl ether by rotary evaporation after the reaction, purify the product through a column, and dry it in vacuum to obtain product 2;

[0...

Embodiment 2

[0035] Embodiment 2: The preparation of a fluorescent sensor capable of ratiometrically detecting hypochlorous acid, the specific steps are as follows:

[0036] (1) Dissolve 4-bromo-1,8-naphthalene dianhydride (10 mmol) and 4-(2-aminoethyl)morpholine (10 mmol) in ethylene glycol methyl ether (10 mL), placed in N 2 Under the conditions of protection and avoiding light, rapidly raise the temperature to 120°C and stir for 4 hours. After the reaction is completed, it is directly added to 40 mL of distilled water to precipitate, and the desired product is obtained by suction filtration, and vacuum-dried to obtain product 1;

[0037] (2) Dissolve the product 1 (3 mmol) synthesized in step (1) in 10 mL of ethylenediamine, and place the mixed solution in the dark and N 2 Stir at 80°C for 4 h under protected conditions, remove most (85-95%) of ethylene glycol methyl ether by rotary evaporation after the reaction, purify the product through a column, and dry it in vacuum to obtain prod...

Embodiment 3

[0041] Embodiment 3: the preparation of a kind of fluorescent sensor that can ratio detect hypochlorous acid, concrete steps are as follows:

[0042] (1) Dissolve 4-bromo-1,8-naphthalene dianhydride (10 mmol) and 4-(2-aminoethyl)morpholine (10 mmol) in ethylene glycol methyl ether (10 mL), placed in N 2 Under the conditions of protection and avoiding light, rapidly raise the temperature to 120°C and stir for 4 hours. After the reaction is completed, it is directly added to 40 mL of distilled water to precipitate, and the desired product is obtained by suction filtration, and vacuum-dried to obtain product 1;

[0043] (2) Dissolve the product 1 (3 mmol) synthesized in step (1) in 10 mL of ethylenediamine, and place the mixed solution in the dark and N 2 Stir at 80°C for 4 h under protected conditions, remove most (85-95%) of ethylene glycol methyl ether by rotary evaporation after the reaction, purify the product through a column, and dry it in vacuum to obtain product 2;

[...

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Abstract

The invention discloses a polymer fluorescence sensor with a hypochlorous acid ratio detection function and application of the polymer fluorescence sensor. The polymer fluorescence sensor is a novel ratio fluorescence sensor prepared from polyethylene glycol monoethyl ether chain transfer agents (PEG-TTC), styrene (St), 4-bromine-1, 8-naphthoyl dianhydride and allyl isothiocyanate. Quick ratio detection can be carried out on the hypochlorous acid by the polymer fluorescence sensor in pure aqueous solution in a high-selectivity and high-sensitivity manner. Compared with existing fluorescence detection technologies, the polymer fluorescence sensor and the application have the advantages that the polymer fluorescence sensor is quick in response to hypochlorous acid high-selectivity ratio, low in cytotoxicity and input cost, excellent in water dispersibility and suitable to be applied to amplified synthesis and actual production and has a huge application prospect in the technical fields such as analytical chemistry, life science and environmental science, synthetic routes are simple, and the like.

Description

technical field [0001] The invention relates to a fluorescent sensor that can be used for hypochlorous acid detection and its application, in particular to a polymer fluorescent sensor that can detect hypochlorous acid ratiometrically and its application, and belongs to the field of chemical material preparation and analysis and detection. Background technique [0002] Reactive oxygen species (ROS) is a very important species that widely exists in biological cells, and it plays a very important role in signal transduction, differentiation, migration and cellular immunity in biological cells. However, ROS all have the common characteristics of high activity, low content, and uneven distribution in organisms. How to explore their functions in organisms has become particularly important. Endogenous hypochlorous acid (HOCl), as an important member of ROS, is hydrogen peroxide (H 2 o 2 ) reacts with chloride ions under the catalysis of myeloperoxidase (MPO). In addition, HOCl ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F283/06C08F212/08C08F226/02C08F2/38G01N21/64
CPCC08F2/38C08F283/06G01N21/643C08F212/08
Inventor 陈建王宏洪永想张培盛余茂林
Owner HUNAN UNIV OF SCI & TECH
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