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Water-based reinforced dampproof film coating premixing agent and preparation method

A technology of film coating and premix, which is applied in the chemical field, can solve problems such as poor moisture-proof effect, achieve the effect of perfect formula, reduce cost, and reduce unsafe hidden dangers

Inactive Publication Date: 2017-03-15
SHANGHAI NEW PHIL BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of water-based strengthening moisture-proof type film coating premix, described this water-based strengthening moisture-proof type film coating premix will solve the moisture-proof of moisture-proof type film coating premix in the prior art Technical Issues That Don't Work Well

Method used

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  • Water-based reinforced dampproof film coating premixing agent and preparation method
  • Water-based reinforced dampproof film coating premixing agent and preparation method
  • Water-based reinforced dampproof film coating premixing agent and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] This example is a typical product in Chinese medicine tablets (Shenbao Tablets). It is a tablet made of 22 kinds of traditional Chinese medicines. and other characteristics.

[0073] Formula 1: talcum powder 31%, aluminum lake 0.7%, iron oxide red 6%, iron oxide yellow 4%, polyvinyl alcohol

[0074] 22%, ethyl methacrylate acrylate polymer, 6.8%, hypromellose 9.5%, macrogol 6000 12%,

[0075] Surfactant 5%. Soy Lecithin 3%.

[0076] According to the provisions of the Pharmacopoeia (Part IV of the Pharmacopoeia, accelerated inspection on page 354), the inspection time was six months under the conditions of a temperature of 40 degrees in an incubator and a humidity of 75 degrees.

[0077] Depend on figure 1 It can be seen that the water-based enhanced moisture-proof coated tablet is compared with the curve of the moisture-proof coated tablet, and it can be seen that it is significantly stronger than the moisture-proof coated tablet sold in the market, effectively impr...

Embodiment 2

[0079] A pure Chinese medicine tablet (Tianshu tablet), composed of Chuanxiong, Gastrodia elata and other materials, characterized by darker color and bitter taste

[0080] Formula 2: talcum powder 20.6%, titanium dioxide 22.16%, aluminum lake 3.95%, polyvinyl alcohol 29.6%, hypromellose 10.66%, ethyl methacrylate acrylate polymer 2.5%, polyethylene glycol 6.58%, β cyclodextrin 0.66, surfactant 3.29%.

[0081] According to the provisions of the Pharmacopoeia (Part IV of the Pharmacopoeia, accelerated inspection on page 354), the inspection time was six months under the conditions of a temperature of 40 degrees in an incubator and a humidity of 75 degrees.

[0082] Depend on figure 2 It can be seen that the comparison of the water-based enhanced moisture-proof coated tablets and the ordinary moisture-proof coated tablets has clearly shown its advantages. Its moisture-proof effect is obviously enhanced, and the weight gain of the coating is less than the original 6%. The weig...

Embodiment 3

[0084] There are rhubarb, bezoar, realgar, borneol, etc. in Niuhuang Jiedu Tablets, which are easy to volatilize and absorb.

[0085] Formula 3: talcum powder 22.31%, titanium dioxide 13.39%, aluminum lake 2.97%, polyvinyl alcohol 17.75%, hypromellose 14.8%, ethyl methacrylate acrylate polymer 7.5%, polyethylene glycol 13.38%, Maltodextrin 7.55%, sodium hydroxide 0.35%.

[0086] According to the provisions of the Pharmacopoeia (Part IV of the Pharmacopoeia, accelerated inspection on page 354), the inspection time was six months under the conditions of a temperature of 40 degrees in an incubator and a humidity of 75 degrees.

[0087] Depend on image 3 It can be seen that the water-based enhanced moisture-proof coating tablet is compared with the plain tablet curve, and the moisture-proof performance is obvious. To solve the multi-layer coating process of this product, we can coat it with water-based enhanced moisture-proof film coating material once, and the success is achiev...

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Abstract

A water-based reinforced dampproof film coating premixing agent is prepared from, by mass, 3-45% of coloring agent, 30-70% of film forming agent, 3-20% of plasticizer and 1-7% of surfactant. The invention further provides a preparation method of the coating premixing agent. Coloring agent materials are mixed and smashed to obtain a mixture uniform in color; a surfactant material is added to the coloring agent mixture for high-shear mixing, and then grinding and smashing are performed; the plasticizer is added to a container, then a film forming agent material is added, then the mixture of the coloring agent and the surfactant is added for mixing, and grinding, smashing and re-mixing are performed, so that the mixture is fully grinded, uniformized and screened to obtain the water-based reinforced dampproof film coating premixing agent. The water-based reinforced dampproof film coating premixing agent plays the good effect on the oil volatility of traditional Chinese medicine tablets and micro pills having various properties, taste masking of veterinary drugs and the like.

Description

technical field [0001] The invention relates to the field of chemistry, in particular to a drug coating technology, in particular to a water-based enhanced moisture-proof film coating premix and a preparation method. Background technique [0002] Film coating premix is ​​currently not only an essential excipient in the pharmaceutical industry, but also a commonly used excipient in the food industry, health care product industry, agriculture, and animal husbandry. [0003] The film coating premixes currently available on the market are suitable for some newly launched products and functional products, such as: easily oxidized, polysaccharides, vitamin series, and natural foods. There are some deficiencies, and it is necessary to have a film coating premix suitable for these characteristics. Contents of the invention [0004] The object of the present invention is to provide a kind of water-based strengthening moisture-proof type film coating premix, described this wate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K47/38A61K47/02
CPCA61K47/32A61K47/02A61K47/38
Inventor 吴兴安左成林
Owner SHANGHAI NEW PHIL BIOLOGICAL TECH CO LTD
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