Fluorescent probe containing tetrasthenylvinyl group and synthesis method and application thereof
A technology of fluorescent probes and tetraphenylethylene, which is applied in the fields of fluorescence/phosphorescence, chemical instruments and methods, and the preparation of organic compounds. The method is simple, easy to modify, and the effect of mild reaction conditions
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[0033] Example 1
[0034] As attached figure 1 And figure 2 Shown is a fluorescent probe containing a tetrastyrene group, the molecular end of the fluorescent probe has a carbon-carbon double bond, and the fluorescent probe includes the following preparation steps:
[0035] (1) Under the condition of nitrogen atmosphere and 0℃, add 22mmol TiCl 4 Add dropwise to the tetrahydrofuran suspension solution containing 44mmol zinc powder, and stir at room temperature for 0.5h; after refluxing for 2.5h, the temperature is lowered to 0°C to prepare a mixed solution;
[0036] (2) Dissolve 12 mmol of benzophenone and 10 mmol of 4'-hydroxy-benzophenone in dry tetrahydrofuran, and add them dropwise to the mixed solution prepared in step (1); reflux, thin-layer plate tracking Reaction process
[0037] (3) After the reaction in step (2) is complete, add water to quench the reaction, and use CH 2 Cl 2 Extract three times; take the organic layer and dry with anhydrous sodium sulfate, column chromatogr...
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[0040] Example 2
[0041] As attached figure 1 And figure 2 Shown is a fluorescent probe containing a tetrastyrene group, the molecular end of the fluorescent probe has a carbon-carbon double bond, and the fluorescent probe includes the following preparation steps:
[0042] (1) Under nitrogen atmosphere and 0℃, add 11mmol TiCl 4 Add dropwise to the tetrahydrofuran suspension solution containing 22mmol zinc powder, and stir at room temperature for 0.5h; after refluxing for 2.5h, the temperature is reduced to 0°C to prepare a mixed solution;
[0043] (2) Dissolve 6mmol of benzophenone and 5mmol of 4'-hydroxy-benzophenone in dry tetrahydrofuran, and add them dropwise to the mixed solution prepared in step (1); reflux, thin-layer plate tracking Reaction process
[0044] (3) After the reaction in step (2) is complete, add water to quench the reaction, and use CH 2 Cl 2 Extract three times; take the organic layer, and dry with anhydrous sodium sulfate, column chromatography to obtain a whi...
Example Embodiment
[0047] Example 3
[0048] As attached figure 1 And figure 2 Shown is a fluorescent probe containing a tetrastyrene group, the molecular end of the fluorescent probe has a carbon-carbon double bond, and the fluorescent probe includes the following preparation steps:
[0049] (1) Under the conditions of nitrogen atmosphere and 0℃, add 44mmol of TiCl 4 Add dropwise to the tetrahydrofuran suspension solution containing 88mmol of zinc powder, and stir at room temperature for 0.5h; after refluxing for 2.5h, the temperature is reduced to 0°C to prepare a mixed solution;
[0050] (2) Dissolve 24 mmol of benzophenone and 20 mmol of 4'-hydroxy-benzophenone in dry tetrahydrofuran, and add them dropwise to the mixed solution prepared in step (1); reflux, thin-layer plate tracking Reaction process
[0051] (3) After the reaction in step (2) is complete, add water to quench the reaction, and use CH 2 Cl 2 Extract three times; take the organic layer and dry with anhydrous sodium sulfate, column chr...
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