Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Strontium-containing bone cement and preparation method

A technology of bone cement and cement, which is applied in the direction of medical formula, medical science, prosthesis, etc., can solve the problems of not lowering the curing temperature of bone cement, not lowering or slowing down the exothermic reaction of bone cement, etc., so as to facilitate heat loss and reduce Damage to the human body, the effect of reducing the accumulation of heat

Inactive Publication Date: 2017-04-26
山东明德生物医学工程有限公司
View PDF5 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many schemes add calcium sulfate and calcium phosphate to bone cement to increase the bioactivity and biocompatibility of bone cement, but cannot reduce or slow down the exothermic reaction of bone cement, and have not lowered the curing temperature of bone cement

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Strontium-containing bone cement and preparation method
  • Strontium-containing bone cement and preparation method
  • Strontium-containing bone cement and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Take by weighing corresponding strontium ranelate (1%), polyacrylate (59%) containing benzoyl peroxide, barium sulfate (10%), calcium sulfate (15%) according to the mass percentage of powder %) and calcium phosphate (15%), uniformly mixed to obtain bone cement powder, a total of 20g;

[0033] (2) Measure 15 g of hydroquinone-containing methacrylate (95%) and N,N dimethyl-p-toluidine (5%) to obtain a bone cement liquid;

[0034] (3) According to the powder-liquid mass ratio of 1.33:1, the powder was added into the liquid and mixed evenly, and solidified to obtain the strontium-containing bone cement. The bone cement injection time was 12 minutes.

[0035] Operability see attached figure 1 As shown in -A, the bone cement can be used for injection in 3 minutes, with an injection time of 12 minutes, and finally solidifies in 20 minutes. figure 1 -B compared with strontium-free bone cement, adding strontium ranelate, the injection time of bone cement was extended from ...

Embodiment 2

[0039] (1) Take by weighing corresponding strontium ranelate (0.01%), polyacrylate (49%) containing benzoyl peroxide, barium sulfate (30%), calcium sulfate (10.99%) according to the mass percentage of powder %) and calcium phosphate (10%), uniformly mixed to obtain bone cement powder, a total of 20g;

[0040] (2) Weigh strontium ranelate (1%) and add it to hydroquinone-containing methacrylate (94%) and N,N dimethyl-p-toluidine (5%), mix well to obtain bone cement Liquid, a total of 10g;

[0041] (3) According to the powder-liquid mass ratio of 2:1, the powder was added to the liquid and mixed evenly, and solidified to obtain the strontium-containing bone cement. The bone cement injection time was 9 minutes.

[0042] Determine the curing temperature of bone cement according to the standard requirements and methods, by figure 2 -E shows that the maximum temperature of the bone cement is 66°C, and the curing time is 16 minutes.

[0043] Measure the compressive strength of bon...

Embodiment 3

[0045] (1) Take by weighing corresponding strontium ranelate (0.2%), polyacrylate (49.8%) containing benzoyl peroxide, barium sulfate (10%), calcium sulfate (30%) according to the mass percentage of powder %) and calcium phosphate (10%), uniformly mixed to obtain bone cement powder, a total of 20g;

[0046] (2) Weigh strontium ranelate (0.3%) and add it to hydroquinone-containing methacrylate (96.9%) and N,N dimethyl-p-toluidine (2.8%), and mix well to obtain bone cement Liquid, 20g in total;

[0047] (3) According to the powder-liquid mass ratio of 1:1, the powder was added into the liquid and mixed evenly, and solidified to obtain the strontium-containing bone cement. The bone cement injection time was 12 minutes.

[0048] Determine the curing temperature of bone cement according to the standard requirements and methods, by figure 2 -F shows that the maximum temperature of the bone cement is 59°C and the curing time is 19 minutes.

[0049]Measure the compressive strength...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle size distribution rangeaaaaaaaaaa
Compressive strengthaaaaaaaaaa
Compressive strengthaaaaaaaaaa
Login to View More

Abstract

The invention provides a strontium-containing bone cement and a preparation method. The bone cement consists of two parts, namely a powder body and liquid; the powder body comprises polyacrylate which contains benzoyl peroxide, a developing agent, calcium salt and strontium ranelate; the liquid comprises methacrylate which contains hydroquinone, N,N-dimethyl-p-toluidine and strontium ranelate; by adding the strontium ranelate to the bone cement, a methacrylate polymer which contains the strontium ranelate is generated, so that heat energy release when the bone cement is polymerized is relieved, curing temperature of the bone cement is reduced, injection performance of the bone cement is enhanced, sufficient operating time is offered to doctors and operating risks are reduced; with the addition of the strontium ranelate, the mechanical performance of the bone cement is improved, so that mechanical performance matching required by human body is relieved, and the biocompatibility and bone regeneration performance of the bone cement are enhanced; and the prepared bone cement, which is higher than 50MPa in compressive strength, can meet a demand of human body bone repair; therefore, the prepared bone cement is a bone repair material which is excellent in performance.

Description

technical field [0001] The invention relates to a strontium-containing bone cement and a preparation method, which are mainly used in the fields of biomedical materials and the like. Background technique [0002] Acrylate bone cement is currently the most clinically used bone cement, which consists of powder and liquid. The main components of the powder are polyacrylate, barium sulfate, benzoyl peroxide (initiator, BPO), and the main components of the liquid are methacrylate (MMA) monomer, N,N dimethyl-p-toluidine and p-benzene diphenols. Acrylate bone cement can be injection molded and made into any shape, and has high mechanical strength, but at the same time, there are some limitations of acrylate bone cement, such as the monomer has certain toxicity, poor biocompatibility, and cannot be absorbed and degraded after being injected into the human body , At the same time, it has no osteogenic effect, is not firmly combined with the bone, and is easy to loosen, and the exot...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/16A61L27/12A61L27/02A61L27/54A61L27/50
CPCA61L27/16A61L27/025A61L27/12A61L27/50A61L27/54A61L2300/102A61L2300/412A61L2400/06A61L2430/02C08L33/08C08L33/10
Inventor 李朝阳崔永顺夏文飞董妍君刘伟铭吕维加
Owner 山东明德生物医学工程有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com