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Placental lipopolysaccharide-polypeptide dual immunopotentiator and preparation method thereof

A technology for lipopolysaccharide and animal placenta, which is applied to the preparation methods of peptides, chemical instruments and methods, and food ingredients containing polysaccharide/gum, etc. Improve the use, sales and reporting of enhancers to achieve the effect of reducing the frequency of taking, improving the taste, and excellent water solubility

Active Publication Date: 2021-01-19
王景仙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, the existing placenta products in the market are single and single-product varieties, and the use, sales and reports of animal placental lipopolysaccharide and polypeptide dual immunopotentiators have not been found. In order to develop this product and put it on the market as soon as possible, a patent of this invention is hereby declared.

Method used

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  • Placental lipopolysaccharide-polypeptide dual immunopotentiator and preparation method thereof

Examples

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Embodiment 1

[0039] A porcine placental lipopolysaccharide-polypeptide dual immunopotentiator, the specific preparation method comprising the following steps:

[0040] 1. Lipopolysaccharide and polypeptide co-production process

[0041] A. Raw material processing: 10 kg of fresh pig placenta that has passed the quarantine inspection is removed from the fetal membranes, umbilical cord, and blood clots, rinsed with pure water, crushed and ground with a meat grinder and colloid mill in turn, and then placed in a freezer below -20°C for 24 hours. , Take out the 37°C water bath to thaw, freeze and thaw three times like this, and then put it in the reaction kettle for digestion and enzymolysis.

[0042] B. Digestive enzymatic hydrolysis: Add physiological saline twice the weight of raw materials to the reaction kettle, add fresh pancreas juice with 30% weight of raw materials, adjust the pH value to 7.5 with saturated calcium hydroxide, heat to 50°C under intermittent stirring, and digest After...

Embodiment 2

[0063] A bovine placental lipopolysaccharide-polypeptide dual immunopotentiator, the specific preparation method comprising the following steps:

[0064] 1. Lipopolysaccharide and polypeptide co-production process

[0065] A. Raw material processing: 20 kg of fresh bovine placenta that has passed the quarantine is removed from the placenta, umbilical cord, blood clot and other appendages, rinsed with pure water, crushed and ground with a meat grinder and colloid mill in turn, and placed in a cold storage below -20°C Quick-freeze for 48 hours, take out the 37°C water bath to thaw, and freeze-thaw 5 times in this way, and then put it in the reaction kettle for digestion and enzymolysis.

[0066] B. Digestive enzymatic hydrolysis: Add physiological saline 3 times the weight of raw materials to the reaction kettle, add fresh pancreas juice with 50% weight of raw materials, adjust the pH value to 8.5 with saturated calcium hydroxide, heat to 55°C under intermittent stirring, and di...

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Abstract

The invention relates to a placental lipopolysaccharide-polypeptide bivalent immunoenhancer and a preparation method thereof. Lipopolysaccharide and polypeptide which are extracted from animal placentas (pig, cattle, sheep and the like) are taken as main raw materials, and the main raw materials are combined with auxiliary materials such as polyethylene glycol and xylitol so as to be prepared into an oral preparation. A formula of the placental lipopolysaccharide-polypeptide bivalent immunoenhancer is that every 100mL of the oral preparation contains 5-30mg of placental lipopolysaccharide, 0.1-1.0g of polypeptide, 3-10g of polyethylene glycol and 1-15g of xylitol. The placental lipopolysaccharide-polypeptide bivalent immunoenhancer provided by the invention has the advantages that a co-production technology is adopted, the modern biological process integration technology and a green biochemical extraction technology are applied, animal placental lipopolysaccharide and placental peptide are perfectly combined, synergistic effects are achieved, immunologic functions of an organism on multiple bacteria and viruses are enhanced, and the placental lipopolysaccharide-polypeptide bivalent immunoenhancer has better curative effects on chronic bronchitis, bronchial asthma and cold prevention of human and animals respectively and can be widely applied to industries of medical treatment as well as prevention and health care on the human and animals. A production process of the immunoenhancer product is pollution-free, the three wastes are not produced, energy conservation and environmental protection are realized, the production cost is low, and economic benefits are obvious.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a placental lipopolysaccharide-polypeptide dual immunopotentiator and a preparation method thereof. Background technique [0002] With the development of modern medicine, cell biology and molecular biology, people gradually realize that the occurrence and development of many diseases are closely related to the functional defects and dysfunction of the body's immune system. Reasons that affect the normal immune system function of the body include: ① various congenital or acquired autoimmune function defects; ② various acute and chronic bacterial and viral infections; Decreased immune function. For the above reasons, regulating or enhancing the immune function of the body has become an important way to prevent and treat diseases. [0003] The placenta is a transitional organ for the exchange of substances between the mother and the child formed by the combination of the embryonic mem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/01A61K31/739C12P21/06C07K1/34A61P37/04A61P11/00A61P11/06A61K35/51
CPCA23V2002/00A61K31/739A61K35/51A61K38/012C07K1/34C12P21/06A23V2200/30A23V2200/324A23V2200/314A23V2250/51A23V2250/6422A23V2250/55Y02P20/10
Inventor 王景仙常功孟春萍王新卫王磊
Owner 王景仙
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