Nanometer carbon micro-crystal modified polylactic acid-based orthopedic material and method for preparing same

Abstract

The invention belongs to the field of preparation of orthopedic materials, and particularly relates to a nanometer carbon micro-crystal modified polylactic acid-based orthopedic material and a method for preparing the same. The nanometer carbon micro-crystal modified polylactic acid-based orthopedic material is made of raw materials including, by weight, 89-98 wt% of lactide, 0.3-2 wt% of catalysts and 1-10 wt% of nanometer carbon micro-crystals. The nanometer carbon micro-crystal modified polylactic acid-based orthopedic material and the method have the advantages of high tensile strength and organism affinity and good dimensional stability.

Description

technical field [0001] The invention belongs to the field of orthopedic material preparation, and in particular relates to a polylactic acid-based orthopedic material modified by nano-carbon crystals and a preparation method thereof. Background technique [0002] In the field of medicine, commonly used orthopedic materials are metal materials and polylactic acid biodegradable materials, but the mechanical properties of metal orthopedic materials, such as strength and toughness, are much greater than those of human bones, and cannot dynamically change with the bone healing process, causing "stress" "masking" phenomenon, and often lead to osteoporosis and bone degeneration; polylactic acid (PLA), also known as polylactide, is polymerized from lactic acid and is a renewable plant resource such as grain or straw as raw material, fermented to obtain lactic acid , and then prepared by polymerization, the polymer material is rich in sources, the production process is pollution-free...

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Problems solved by technology

[0002] In the field of medicine, commonly used orthopedic materials are metal materials and polylactic acid biodegradable materials, but the mechanical properties of metal orthopedic materials, such as strength and toughness, are much greater than those of human bones, and cannot dynamically change with the bone healing process, causing "stress" "masking" phenomenon, and often lead to osteoporosis and bone degeneration; polylactic acid (PLA), also known as polylactide, is polymerized from lactic acid and is a renewable plant resource such as grain or straw as raw material, fermented to obtain lactic acid , and then prepared by polymerization, the polymer material is rich in sources, the production process is pollution-free and the product can be biodegraded. It is an ideal green polymer material. Compared with metal materials, polylactic acid biodegradable materials can be degraded and absorbed to avoid healing. After the second operation, it can effectively overcome the "stress shielding" and improve the effect of bone self-repair. However, as an orthopedic material, polylactic acid has disadvantages such as low strength, large thermal expansion coefficient, poor toughness, and poor affinity with organisms. For example, the Chinese invention patent "Preparation method of nano-carbon apatite / chitosan-polylactic acid bone tissue engineering scaffold material" (publication number CN101491702 B), it is made of glacial acetic acid and a small amount of water as polylactic acid and chitosan The co-solvent of sugar is prepared into a co-solution of polylactic acid and chitosan, and the powdered nano-carbon apatite is directly added to the co-solution of polylactic acid and chitosan, and then NaOH solution is added to form a phase separation to prepare nano-carbon phosphorus Limestone / chitosan-polylactic acid porous composite scaffold material

[0003] Nanocarbon crystal is a new type of carbon nanomaterial with an average size between 2-5nm. It has the characteristics of high strength, good wear resistance, large specific surface area, large surface activity, and easy functional modification. Therefore, its Adding it will definitely enhance the polylactic acid; at the same time, it has excellent biocompatibility, can be excreted with normal metabolism, and has no toxic side effects on the body. It is an excellent biopolymer modified material , but because nanocarbon crystals are easy to agglomerate like ordinary nanomaterials, the existing technology cannot uniformly disperse nanomaterials into polylactic acid, so the existing methods for preparing polylactic acid-based orthopedic materials need to be further improved

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