Method for preparing gold nanoclusters based on microfluidic chip

A microfluidic chip, a technology for preparing gold, applied in the fields of nanotechnology, nanotechnology, nanotechnology, etc. for materials and surface science, can solve the breakthrough in the synthesis method of blocked gold clusters and the application, the complex separation process, and the reaction conditions. Harsh and other problems, to achieve uniform morphology, accurate droplet fusion, good crystallinity

Active Publication Date: 2017-06-13
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The Brust-Schiffrin method requires reaction at 0°C with very low stirring speed to synthesize Au 25 Nano-cluster materials, harsh reaction conditions, complicated separation process, long synthesis cycle (3 days), low yield (30%-40%), which seriously hinder the breakthrough and application of gold cluster synthesis method

Method used

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  • Method for preparing gold nanoclusters based on microfluidic chip
  • Method for preparing gold nanoclusters based on microfluidic chip
  • Method for preparing gold nanoclusters based on microfluidic chip

Examples

Experimental program
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Effect test

Embodiment 1

[0037] The mixing of different reactants and the progress of the reaction, using figure 1 The chip with the structure shown is shown in figure 2. The syringe pump continuously infused ethanol solution into reservoir A at a flow rate of 600nl / min, continuously infused deionized water into reservoir B at a flow rate of 300nl / min, and continuously injected deionized water into reservoir C at a flow rate of 100nl / min~900nl / min. Perfuse with 20mg / ml methylene blue dye solution. A laminar mixed fluid is formed at the first Y-shaped channel, and driven by mineral oil, it flows along the channel and meets the methylene blue solution at the second Y-shaped channel, which is realized after collision under the shear stress of the fluid. mix. Keep the flow rate of ethanol and deionized water unchanged, increase the flow rate of methylene blue solution from 100nl / min to 900nl / min, the methylene blue solution can be accurately fused with the previous solution, and the color of the fused...

Embodiment 2

[0039] Dissolve chloroauric acid and tetraoctylammonium bromide (molar ratio 1:1.2) in tetrahydrofuran to form a 0.1mol / L solution, dissolve sodium borohydride in ice water to form a 0.5mol / L solution, and use a syringe pump to The tetrahydrofuran solution of chloroauric acid / tetraoctylammonium bromide was continuously perfused into reservoir A at a flow rate of 500 nl / min, and n-dodecyl mercaptan solution was continuously perfused into reservoir B at a flow rate of 300 nl / min using a syringe pump to The flow rate of 300nl / min continuously perfuses 0.5mol / L sodium borohydride solution to the reservoir C, and the tetrahydrofuran mixture meets n-dodecyl mercaptan at the primary Y-shaped channel, and the gold(Ⅲ) in the chloroauric acid It is reduced to gold (I), and the two are mixed into a primary solution under the shearing action of the continuous fluid. Meet, after secondary mixing, realize the mixing of reaction substances, after mixing, a homogeneous mixed solution is forme...

Embodiment 3

[0042] Dissolve chloroauric acid and tetraoctylammonium bromide (1:1.3) in methanol to form a 0.15mol / l solution, and dissolve sodium borohydride in ice water to form a 0.6mol / L solution. Use a syringe pump to continuously perfuse the methanol solution of chloroauric acid / tetraoctylammonium bromide to the reservoir A at a flow rate of 600 nl / min, and use a syringe pump to continuously perfuse the n-hexanethiol solution to the reservoir B at a flow rate of 300 nl / min. Continuously perfuse 0.6mol / L sodium borohydride solution into the reservoir C at a flow rate of 150nl / min, and the tetrahydrofuran mixture meets n-hexanethiol at the first Y-shaped channel, and the gold (Ⅲ) in the chloroauric acid is absorbed It is reduced to gold (I), and the two are mixed into a primary solution under the shearing action of the continuous fluid, and the solution moves downstream of the channel, and meets the monodisperse reducing body solution C at the secondary Y-shaped channel, and after secon...

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Abstract

The invention provides a method for preparing gold nanoclusters based on a microfluidic chip and belongs to the field of gold nanocluster synthesis methods. The method is characterized in that gold nanoclusters which have small monodisperse particle sizes and are protected by an alkyl carbon chain sulfhydryl monolayer are synthesized based on the microfluidic chip, hydrophobic modification is performed on the inner wall of the chip channel, and drops can be stably and smoothly formed and fused accurately and are uniform in size. Meanwhile, by the method, the drop sizes are small, chaotic mixing and mass transfer velocities are high, and reactants are uniformly distributed in the channel to facilitate nucleation and growth of nano-particles. The microfluidic chip is made of a transparent PDMS material, the material formation can be monitored and regulation and control can be performed on line in real time through integration with a microscope, the chip is simple in design, a plurality of groups of parallel reaction channels can be easily constructed, high-throughout synthesis can be performed, and the product yield is improved.

Description

technical field [0001] The invention belongs to the field of synthesis methods of gold nanoclusters, and in particular relates to a method for preparing gold nanoclusters based on a microfluidic chip. Background technique [0002] Monolayer-protected gold nanoclusters have unique size effect and excellent physical, chemical and electronic properties, and have attracted people's attention in many fields such as self-assembly, biolabeling, catalysis, electron transfer theory, and DNA immunoassay. Akola et al. calculated through theoretical calculations that Au 25 (SR) 18 Structure of the cluster, confirmed by Heaven et al. by single crystal X-ray crystallography, Au 25 (SR) 18 Clusters have become one of the main directions for scientists to study gold clusters. The purpose of their research is to develop a method with simple operation and short synthesis cycle to obtain materials with uniform morphology, narrow particle size distribution and monodispersity. Among them, how...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00B22F9/24B22F1/07B22F1/102B22F1/054
Inventor 牛利许佳楠贾菲李风华张齐贤安清波
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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