Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of antimicrobial coating of implantable medical device

A technology for medical devices and antibacterial coatings is applied in the field of preparation of antibacterial coatings to achieve the effects of simple preparation process, increased contact area, and easy large-scale production

Inactive Publication Date: 2017-06-23
MICROPORT SORIN CRMSHANGHAICO LTD
View PDF6 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The object of the present invention is to provide the preparation method of the antibacterial coating of implantable medical device, overcome the limitation that coating treatment is only carried out on the surface of titanium sheet in the prior art, solve the active implanted medical device surface with complex structure Issues with Antimicrobial Coating Treatments

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of antimicrobial coating of implantable medical device
  • Preparation method of antimicrobial coating of implantable medical device
  • Preparation method of antimicrobial coating of implantable medical device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Such as Figure 1-Figure 6 Shown, the invention provides the preparation method of the antibacterial coating of implantable medical device, comprises the steps:

[0050] S1: Soak the implantable medical device 1 in a solution containing dopamine for treatment, take it out and dry it with nitrogen at room temperature for later use, and obtain a surface-treated implantable medical device 2;

[0051] S2: Put the mask plate 3 on the surface-treated metal part of the implantable medical device 2, and then spray the coating solution on the surface of the implantable medical device;

[0052] S3: remove the mask, wait until the solvent is completely volatilized, and obtain an implantable medical device containing an antibacterial coating 4;

[0053] Wherein, the shape of the mask 3 matches the shape of the metal part of the implantable medical device 1 , and holes are opened on the surface of the mask 3 . Preferably, the mask plate 3 is made of polydimethylsiloxane (PDMS).

...

Embodiment 2

[0074] The preparation method of the antibacterial coating of the implantable medical device provided in this example is basically the same as that of Example 1, and only the differences will be described below.

[0075] In this embodiment, the solution containing dopamine in the step S1 is a Tris-HCl solution of dopamine, the pH value of the solution is 8.5, and the concentration of dopamine in the solution is 0.03mol / L. Soak in Tris-HCl solution of dopamine for 6h.

[0076] The mask in the step S2 is made of polydimethylsiloxane (PDMS). The holes on the surface of the mask are square holes with a size of 2mm×2mm and a porosity of 70%.

[0077] The coating solution is composed of medicine, polymer and solvent, and the components of the coating solution are: 1% of medicine, 2% of polymer and 97% of solvent in terms of mass percentage.

[0078]Among them, the drug is preferably rifampicin; the polymer is preferably a copolymer of lactic acid and glycolide; the solvent is prefe...

Embodiment 3

[0082] The preparation method of the antibacterial coating of the implantable medical device provided in this example is basically the same as that of Example 1, and only the differences will be described below.

[0083] In this embodiment, the solution containing dopamine in the step S1 is a Tris-HCl solution of dopamine, the pH value of the solution is 8.5, and the concentration of dopamine in the solution is 0.04mol / L. Soak in Tris-HCl solution of dopamine for 8h.

[0084] The mask in the step S2 is made of polydimethylsiloxane (PDMS), and the holes on the surface of the mask are circular holes with a diameter of 3mm and a porosity of 80%.

[0085] The coating solution is composed of medicine, polymer and solvent. According to mass percentage, the composition of the coating solution is: 3% of medicine, 5% of polymer and 92% of solvent.

[0086] Among them, the drug is preferably cephalosporin; the polymer is preferably polyethylene glycol-polylactic acid-polyglutamic acid ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Concentrationaaaaaaaaaa
Thicknessaaaaaaaaaa
Apertureaaaaaaaaaa
Login to View More

Abstract

The invention provides a preparation method of an antimicrobial coating of an implantable medical device. The preparation method comprises the following steps: soaking and processing the implantable medical device in a solution containing dopamine, taking out the implantable medical device and blow-drying the implantable medical device by virtue of nitrogen at room temperature for later use, so that the surface-treated implantable medical device is obtained; bushing a mask on a metal part of the surface-treated implantable medical device, and then spraying a coating solution onto the surface of the implantable medical device; and taking down the mask, and waiting for complete volatilization of a solvent, so that the implantable medical device comprising the antimicrobial coating is obtained, wherein the mask is matched with the metal part of the implantable medical device in shape, and holes are formed in the surface of the mask. With the application of the preparation method of the antimicrobial coating of the implantable medical device provided by the invention, limitation of the prior art that coating treatment is only conducted on the surface of a titanium sheet is avoided, and problems on conducting antimicrobial coating treatment on the surface of an active implantable medical device of a complex structure are solved.

Description

technical field [0001] The invention belongs to the field of medical equipment, and relates to a preparation method of an antibacterial coating of an implantable medical equipment. Background technique [0002] Implantable medical devices (IMD: implantable medical devices) are used in the human body to treat a large number of patients on the one hand, but at the same time there are some negative effects, the most typical being infection. [0003] When a typical IMD such as a pacemaker is implanted, a pouch is created under the skin. Although the pacemaker will be packaged aseptically before implantation, and the implantation is also performed in a sterile environment, it is difficult to avoid the entry of microorganisms pouch. Therefore, preoperative doctors will use disinfectants or antibacterial agents (such as chlorhexidine, gluconate, iodophor, isopropanol, ethanol, etc.) on the skin of the surgical incision, and will directly use disinfection before the incision is clo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L31/10A61L31/14A61L31/16B05D3/10B05D1/32
CPCA61L31/146A61L31/10A61L31/148A61L31/16A61L2300/404A61L2300/604A61L2300/606A61L2420/02A61L2420/06A61L2420/08B05D1/325B05D3/102B05D2508/00B05D2518/00
Inventor 周涓王亚茹王林林杨莹王励
Owner MICROPORT SORIN CRMSHANGHAICO LTD