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Water-sensitive adhesion ointment based on water-free technology and preparation method of water-sensitive adhesion ointment

An adhesive and water-sensitive technology, applied in the field of medicine, can solve the problems of poor mucous membrane adhesion, poor water absorption, gel slipping, etc., and achieve the effect of prolonging the drug action time, reducing irritation, and eliminating allergic reactions

Inactive Publication Date: 2017-06-30
任君刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, even bioadhesive gels have poor initial water absorption at the site of administration due to the use of water in the preparation process, resulting in poor adhesion to mucous membranes, especially in the oral cavity, which is easier Gel slips from the site of action due to mechanical movement of the gums and tongue

Method used

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  • Water-sensitive adhesion ointment based on water-free technology and preparation method of water-sensitive adhesion ointment
  • Water-sensitive adhesion ointment based on water-free technology and preparation method of water-sensitive adhesion ointment
  • Water-sensitive adhesion ointment based on water-free technology and preparation method of water-sensitive adhesion ointment

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preparation example Construction

[0025] A water-sensitive adhesive ointment based on anhydrous technology and a preparation method thereof. The water-sensitive adhesive ointment is mainly used for topical administration, including: local skin, oral mucosa, gingival mucosa, tongue mucosa, nasal cavity mucosa and vaginal mucosa.

[0026] A water-sensitive adhesive ointment based on anhydrous technology and a preparation method thereof consist of an ointment base, a thickener, a wetting agent, a flavoring agent and a medicine. The prescription is composed of 20-75% of ointment base, 5-25% of thickening agent, 0-25% of wetting agent, 0.01-2.5% of corrective agent and 0-15% of medicine.

[0027] The ointment base in the water-sensitive adhesive ointment based on anhydrous technology is: isopropyl myristate, peanut oil, soybean oil, liquid paraffin, paraffin wax, beeswax, stearic acid, petrolatum, lanolin, polydimethylsiloxane One or more of methyl siloxanes. Preferably: liquid paraffin, paraffin wax, lanolin, an...

Embodiment 1

[0042] Take the preparation of 100g as an example, calculated by mass:

[0043] prescription:

[0044]

[0045] Process: take the prescribed amount of paraffin, liquid paraffin, lanolin and polydimethylsiloxane, heat at 75°C until melted, stir evenly to obtain A, set aside; add allantoin, dexamethasone, xylitol, mannose Add alcohol and menthol to hydroxyethyl urea, stir and disperse evenly to obtain B; add hydroxyethyl cellulose, polyvinyl alcohol, and sodium carboxymethyl cellulose to B in turn, and stir evenly to obtain C; stir C Transfer to A, mix well, cool to room temperature, that is. This prescription is for the treatment of oral mucosal inflammation.

Embodiment 2

[0047] Take the preparation of 100g as an example, calculated by mass:

[0048] prescription:

[0049]

[0050] Process: Take the prescribed amount of isopropyl myristate, soybean oil and beeswax and heat it at 80°C until it melts, stir evenly to obtain A, and set aside; add chlorhexidine acetate, borneol and menthol to hydroxyethyl urea and poly In the ethylene glycol mixture, stir and disperse evenly to obtain B; add sodium polyacrylate and polyvinyl alcohol to B in turn, and stir evenly to obtain C; transfer C to A while stirring, mix evenly, and cool to room temperature, that is have to. This prescription is for the treatment of gingival mucosal inflammation.

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Abstract

The invention relates to water-sensitive adhesion ointment based on a water-free technology and a preparation method of the water-sensitive adhesion ointment. The water-sensitive adhesion ointment is mainly used for local drug application and is prepared from prescription components in percentage by mass as follows: 20%-75% of an ointment substrate, 5%-25% of a tackifier, 0-25% of a moisture absorption agent, 0.01%-2.5% of a flavoring agent and 0-15% of drugs, wherein the ointment substrate is taken, heated or not heated to a liquid state and then mixed uniformly; the tackifier, the moisture absorption agent, the flavoring agent and the drugs are sequentially added to the ointment substrate, the mixture is stirred uniformly to be pasty, and the product is obtained. The ointment absorbs water on the periphery of the drug application part through powerful water absorbency, and tackiness of the tackifier is further induced, so that the ointment has higher local adhesion; the drugs in the ointment are released lastingly in a positioned manner at the drug application part, the antibacterial, sterilizing and anti-inflammation functions of the drugs are further prolonged, and the disease treatment effect is enhanced.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a water-sensitive adhesive ointment based on anhydrous technology and a preparation method thereof. Background technique [0002] Although infectious diseases such as mucous membranes and skin are not serious enough to endanger people's lives, the pain and discomfort they bring will bring inconvenience to people's work and life, such as oral ulcers, mouth sores, skin infections, vaginal inflammation, etc. If it is not treated in time, secondary infection may occur and cannot be controlled. [0003] For this type of infection, there are various treatment methods, such as oral medicine, physical therapy, and topical administration. Oral administration is not safe because it involves absorption into the systemic circulation; physical therapy requires specific equipment and is not suitable for all medication sites, and there are limitations; local administration can ef...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/14A61K47/44A61K47/12A61K47/06A61K47/34A61K47/38A61K47/36A61K47/32A61K47/10A61K47/18A61K47/22A61K45/00A61K31/573A61K31/155A61K31/496A61K31/506A61K31/4164A61K31/525A61K31/135A61K31/4545A61K36/8888A61P29/00A61P17/00A61P37/08A61P31/10A61P31/04A61K31/375
CPCA61K9/0014A61K9/0034A61K9/0043A61K9/006A61K9/06A61K31/135A61K31/155A61K31/375A61K31/4164A61K31/4545A61K31/496A61K31/506A61K31/525A61K31/573A61K36/355A61K36/484A61K36/718A61K36/754A61K36/8888A61K45/00A61K47/06A61K47/10A61K47/12A61K47/14A61K47/18A61K47/22A61K47/32A61K47/34A61K47/36A61K47/38A61K47/44A61K2236/333A61K2236/51A61K2300/00
Inventor 任君刚
Owner 任君刚