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A kind of ceramic material with biological activity, preparation method and application thereof

A ceramic material and bioactive technology, applied in the field of biomedical materials, can solve the problems of low production yield, increased production cost, harsh conditions, etc., and achieve excellent corrosion resistance, low defective rate, and stable product performance. Effect

Active Publication Date: 2019-08-06
NANJING TONGLI CRYSTAL MATERIALS RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, most of the materials that can induce the formation of hydroxyapatite have poor toughness, and the degradation rate is too fast and the stability is not good, which prevents its application in biomedicine.
In addition, the current preparation methods of biological materials have harsh requirements and a low yield rate, which directly leads to an increase in production costs and is not conducive to popularization and application.

Method used

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  • A kind of ceramic material with biological activity, preparation method and application thereof
  • A kind of ceramic material with biological activity, preparation method and application thereof
  • A kind of ceramic material with biological activity, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) According to Ca 10 Si 3 o 15 f 2 The molar ratio of the elements in the medium, weighed calcium carbonate CaCO 3 : 9 grams, silicon oxide SiO 2 : 1.8027 g, ground and mixed in an agate mortar, pre-sintered in an air atmosphere, the sintering temperature is 800 ° C, the sintering time is 10 hours, then cooled to room temperature, and the sample is taken out; the pre-sintered raw material is again mixed with 0.7808 g of Calcium fluoride (CaF) 2 Fully mix and grind evenly, press the mixed powder into shape, the pressing pressure is 10MPa; calcining again in the air atmosphere, the calcining temperature is 1200°C, the calcining time is 5 hours, and the bioceramic is obtained by natural cooling.

[0030] Mineralize the prepared calcium fluorosilicate ceramic block in simulated body fluid for 1 to 7 days, characterize the surface morphology, phase structure and components of the ceramic body after mineralization, and judge whether there are similar Bone apatite laye...

Embodiment 2

[0039] (1) According to Ca 10 Si 3 o 15 f 2 The molar ratio of the elements in the medium, weighed calcium carbonate Ca(OH) 2 : 5.1863 g, silicic acid H 2 SiO 3 : 2.34 grams, ground and mixed in an agate mortar, pre-sintered in an air atmosphere, the sintering temperature was 950 ° C, the sintering time was 4 hours, then cooled to room temperature, and the sample was taken out; the pre-sintered raw material was again mixed with 2.3424 grams of fluorine CaF 2 Thoroughly mix and grind evenly, then carry out compression molding, the pressing pressure is 15MPa, calcining again in the air atmosphere, the calcining temperature is 950°C, the calcining time is 10 hours, and the calcium fluorosilicate bioceramic is obtained by natural cooling.

[0040] Put the prepared calcium fluorosilicate ceramics into the simulated body fluid for mineralization for 7 days, observe the surface morphology after mineralization, judge whether there is a bone-like apatite layer on the surface of t...

Embodiment 3

[0047] (1) According to Ca 10 Si 3 o 15 f 2 The molar ratio of elements in the medium, weighed calcium oxalate CaC 2 o 4 : 10.248 g, silicic acid H 2 SiO 3 : 2.34 g, ground and mixed in an agate mortar, pre-sintered in an air atmosphere, the sintering temperature was 900 ° C, the sintering time was 6 hours, then cooled to room temperature, the sample was taken out and ground evenly; the pre-sintered raw material was again mixed with 1.5616 g calcium fluoride CaF 2 Mix well and grind evenly, press the mixed powder with a pressing pressure of 12MPa, calcining again in air atmosphere, calcining temperature 1000°C, calcining time 9 hours, natural cooling to obtain calcium fluorosilicate bioceramics.

[0048] Put the prepared calcium fluorosilicate ceramics into the simulated body fluid for mineralization for 1 day, observe the surface morphology changes after mineralization, judge whether there is a bone-like apatite layer on the surface of the calcium fluorosilicate cerami...

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Abstract

The invention discloses a ceramic material with bioactivity as well as a preparation method and application thereof. The chemical formula of the ceramic material with bioactivity is Ca10Si3O15F2. A calcium fluosilicate biological ceramic material prepared with the method can improve the toughness of the ceramic material; meanwhile, by the introduction of fluorine, sedimentation of hydroxyapatite on the surface of biological ceramic in a mineralization process can be accelerated; as the mineralization time goes by, the thickness of the hydroxyapatite is increased, the hydroxyapatite cannot be degraded, and external acid attack can also be resisted. The preparation method is simple, extremely low in defective percentage, stable in product performance and high in repetitiveness; no waste gas is discharged, and the preparation method is environment-friendly; the prepared ceramic material is high in bioactivity, excellent in toughness and high in intensity, and can be used as a filling material for bone repair, bone defect repair and tooth repair.

Description

technical field [0001] The invention relates to a biologically active ceramic material, a preparation method and an application thereof, belonging to biomedical materials. Background technique [0002] Bone defect repair materials are one of the materials with the greatest clinical demand. At present, with the aging population, fractures caused by traffic accidents, and bone tissue necrosis, the number of patients with bone defects is increasing day by day. The market for bone repair materials is huge. Finding better bone tissue regeneration and repair materials is a hot spot in the research of medical biomaterials. Obtaining new bionic artificial bone repair materials has become one of the main trends in the development of biomaterials. [0003] Bioceramics is an important research direction of tissue engineering. It is a new type of bionic artificial bone repair material. Due to its potential market value, it has been studied in many aspects; Wide range of applications. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/10C04B35/16C04B35/622C04B35/64A61L27/32A61L27/50
CPCA61L27/10A61L27/32A61L27/50A61L2400/18A61L2420/02A61L2430/02A61L2430/12C04B35/16C04B35/622C04B35/64C04B2235/3208C04B2235/3418C04B2235/445C04B2235/96C04B2235/9669
Inventor 乔学斌
Owner NANJING TONGLI CRYSTAL MATERIALS RES INST CO LTD