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A kind of medical skin wound anti-inflammatory gel and preparation method thereof

A gel and skin technology is applied in the field of medical skin wound anti-inflammatory gel to achieve the effects of good comfort, good plasticizing effect and enhanced moisturizing effect

Inactive Publication Date: 2020-06-23
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

General gel dressings need to meet performance requirements such as certain strength, control and absorption of exudate, moisturizing, antibacterial, analgesic, non-toxic, harmless and non-irritating. However, it is difficult for existing medical gels, especially alginate gels, to simultaneously meet these requirements

Method used

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  • A kind of medical skin wound anti-inflammatory gel and preparation method thereof
  • A kind of medical skin wound anti-inflammatory gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of amorphous gel:

[0027] (1) Preparation of oxidized alginate: take 5 parts by weight of sodium alginate and prepare an aqueous solution with a mass fraction of 1%, oxidize with 3 parts of 0.28mol / L sodium periodate solution in the dark for 36 hours, and then add 0.8 parts of ethylene glycol to terminate the oxidation reaction, add 0.1 parts of NaCl and mix well, then add 75 parts of ethanol, wait for precipitation;

[0028] (2) Preparation of liquid A: Weigh 8 parts of carbomer, 12 parts of maltooligosaccharide, 0.1 part of ciprofloxacin, 5 parts of synthetic borneol, and 20 parts of glycerin according to parts by weight, add 50 parts of purified water and store at room temperature Stir under low temperature until it is completely wetted, and filter off the insoluble matter under heat to obtain liquid A;

[0029] (3) Cross-linking reaction: Take 0.5 parts by weight of the oxidized alginate prepared above, add 10 parts of 2-(N-morpholine)ethanesulfonic ac...

Embodiment 2

[0032] Preparation of amorphous gel:

[0033] (1) Preparation of oxidized alginate: take 7 parts by weight of potassium alginate and prepare an aqueous solution with a mass fraction of 4%, oxidize with 4 parts of 0.25mol / L sodium periodate solution in the dark for 24 hours, and then add 1 part of ethylene glycol to stop the oxidation reaction, add 0.3 parts of NaCl and mix well, then add 100 parts of ethanol, wait for precipitation;

[0034] (2) Preparation of liquid A: Weigh 6 parts of carbomer, 10 parts of maltooligosaccharide, 5 parts of anti-inflammatory agent rifamycin, 20 parts of polyethylene glycol, and 5 parts of humectant propylene glycol by weight, add purified water After 40 parts, stir at room temperature until it is completely wetted, and filter off the insoluble matter by hot filtration to obtain liquid A;

[0035] (3) Cross-linking reaction: Take 0.4 parts by weight of the oxidized alginate prepared above, add 5 parts of 2-(N-morpholine)ethanesulfonic acid buf...

Embodiment 3

[0038] Preparation of solid flake gel:

[0039](1) Preparation of oxidized alginate: take 10 parts by weight of ammonium alginate and prepare an aqueous solution with a mass fraction of 5%, oxidize with 1 part of 0.3mol / L sodium periodate solution in the dark for 48 hours, and then add 0.1 part of ethylene glycol to terminate the oxidation reaction, add 0.5 part of NaCl and mix well, then add 60 parts of ethanol, wait for precipitation;

[0040] (2) Preparation of liquid A: Weigh 10 parts of carbomer, 15 parts of maltooligosaccharide, 3 parts of metronidazole, 10 parts of transdermal absorption accelerator propylene glycol, 10 parts of dimethyl sulfoxide, and humectant according to parts by weight. Add 10 parts of mannitol, add 60 parts of purified water, stir at room temperature until completely wetted, heat filter to remove insoluble matter, and obtain liquid A;

[0041] (3) Cross-linking reaction: Take 0.3 parts by weight of the oxidized alginate prepared above, add 15 par...

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Abstract

The invention relates to a medical skin wound anti-inflammatory gel and a preparation method thereof. The anti-inflammatory gel is formed by compounding a gel matrix with the following components in parts by weight: 5-10 parts of carbomer, 10-20 parts of maltooligosaccharide, 0.1-5 parts of an anti-inflammatory agent, 5-20 parts of a skin penetration absorption enhancer, 5-20 parts of a moisturizing agent and 40-70 parts of purified water; the gel matrix is formed by carrying out a crosslinking reaction of oxidized alginate and a diamine or dihydrazine substance. The alginate is partially oxidized through a sodium periodate by a specific process, carboxyl active groups in alginic acid can be activated, generation of the crosslinking reaction is accelerated, and the production efficiency of the gel is improved; the formed composite alginate gel has high cohesive energy, and can be applicable to wounds at any part; the skin wound anti-inflammatory gel is mainly used in dry and scabby wounds or wounds with rotten tissues, and can inhibit propagation of in-vivo harmful bacteria and production of toxic rotten substances, exerts an anti-inflammatory, hemostatic, antibacterial and debridement effects, and accelerates wound healing.

Description

technical field [0001] The invention relates to the technical field of medical consumables, and specifically includes a medical skin wound anti-inflammatory gel. Background technique [0002] When the skin and mucous membrane are injured, a suitable dressing should be selected to cover the wound. It can maintain a moist environment for the wound, absorb secretions, relieve pain and control bleeding, thereby promoting rapid wound healing. Studies have shown that wounds heal twice as fast in wet environments as in dry environments, leading to new insights into the wound healing process. Inflammatory factors are one of the key factors affecting the mission of wounds. A large number of inflammatory factors, proteases and free radicals contained in wound exudate will slow down the healing speed of wounds. The research and development of new composite analgesic functional materials is of great significance to the treatment of inflammatory wounds, and is a new trend in the develop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/32A61K47/26A61K47/10A61K47/44A61K31/496A61K31/395A61K31/4164A61P29/00A61P7/04A61P31/02A61P17/02C08B37/04
CPCA61K9/0014A61K9/06A61K31/395A61K31/4164A61K31/496A61K47/10A61K47/26A61K47/32A61K47/36A61K47/44C08B37/0084
Inventor 卢亢陈锦涛熊亮
Owner GUANGDONG TAIBAO MEDICAL SCI TECH