PH-sensitive self-repairing hydrogel and preparation method of same

A self-healing and hydrogel technology, applied in medical science, aerosol delivery, liquid delivery, etc., can solve problems such as self-healing, limited application in the field of biomedicine, and lack of self-healing performance, etc., achieving low cost, Wide source and good biocompatibility

Inactive Publication Date: 2017-07-14
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prepared material does not have self-healing properties, and cannot self-repair due to e

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0021] Example 1

[0022] (1) Preparation of dopamine-modified sodium alginate: Weigh a certain quality of sodium alginate, dissolve it in 2-(N-morpholine) ethanesulfonic acid (MES) buffer with a pH of 5.5, and prepare the mass concentration as 1% solution, then dissolve 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) with a mass ratio of 5 In the above sodium alginate solution, react at 20°C for 40min, then add a certain mass proportion of dopamine, 20°C, under nitrogen protection, continue to stir the reaction for 24h, then put it into a dialysis bag with a molecular weight cutoff of 3500Da, and dialyzed with distilled water 3 After days, the retentate was freeze-dried for 72 hours at a pressure of 10 Pa and a temperature of -50°C to prepare dopamine-modified sodium alginate;

[0023] (2) Preparation of 3-aminophenylboronic acid-modified sodium carboxymethyl cellulose: Weigh a certain mass of sodium carboxymethyl cellulose, dissol...

Example Embodiment

[0025] Example 2

[0026] (1) Preparation of dopamine-modified sodium alginate: Weigh a certain quality of sodium alginate, dissolve it in 2-(N-morpholine) ethanesulfonic acid (MES) buffer with a pH of 6.5, and prepare the mass concentration as 2.5% solution, and then dissolve 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) with a mass ratio of 5 In the above sodium alginate solution, react for 30 minutes at 25°C, then add a certain mass proportion of dopamine, 25°C, under nitrogen protection, continue to stir the reaction for 24h, then put it into a dialysis bag with a molecular weight cut-off of 8000Da, and dialyzed with distilled water 3 After days, the retentate was freeze-dried for 72 hours at a pressure of 20 Pa and a temperature of -55°C to prepare dopamine-modified sodium alginate;

[0027] (2) Preparation of 3-aminophenylboronic acid-modified sodium carboxymethyl cellulose: Weigh a certain mass of sodium carboxymethyl cellu...

Example Embodiment

[0029] Example 3

[0030] (1) Preparation of dopamine-modified sodium alginate: Weigh a certain quality of sodium alginate, dissolve it in 2-(N-morpholine) ethanesulfonic acid (MES) buffer with a pH of 5.5, and prepare the mass concentration as 5% solution, then dissolve 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) with a mass ratio of 2.5 In the above sodium alginate solution, react at 37°C for 20 minutes, then add a certain mass ratio of dopamine, and continue to stir the reaction for 24 hours at 37°C under nitrogen protection, then put it into a dialysis bag with a molecular weight cut-off of 8000Da, and dialyzed with distilled water 3 After days, the retentate was freeze-dried at a pressure of 20 Pa and a temperature of -55°C for 60 hours to prepare dopamine-modified sodium alginate;

[0031] (2) Preparation of 3-aminophenylboronic acid-modified sodium carboxymethyl cellulose: Weigh a certain mass of sodium carboxymethyl cell...

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Abstract

The invention discloses a pH-sensitive self-repairing hydrogel and a preparation method of same. The hydrogel is produced by crosslinking dopamine-modified sodium alginate and sodium carboxymethylcellulose modified by 3-aminophenylboronic acid according to a certain ratio, wherein the modified sodium alginate and sodium carboxymethylcellulose respectively have a catechol group and a phenylboronic acid group, so that between the two groups, a pH-sensitive phenylborate bond can be formed. The phenylborate bond is fractured if pH < 7 and is recovered if pH > 7, so that the hydrogel has a pH-responded self-repairing performance. A main raw material of the hydrogel is natural polysaccharide, so that the hydrogel has excellent biocompatibility and also has pH-responding property and self-repairing performance. The hydrogel has wide applications in the fields of controllable release of drugs, tissue engineering and the like.

Description

technical field [0001] The invention relates to a hydrogel with pH-sensitive self-healing property, good biocompatibility and proper expansion rate and a preparation method thereof, belonging to the field of preparation of biomedical materials. Background technique [0002] Hydrogel has a three-dimensional space network structure and is a hydrophilic cross-linked polymer that can absorb water and swell but is insoluble in water. Hydrogels are soft, can maintain a certain shape and have certain fluid properties, which is due to the fact that the hydrophilic groups in the hydrogel polymer can bind water and restrict the mobility of water. According to the different responses to external stimuli, hydrogels can be divided into traditional hydrogels and environment-sensitive hydrogels. Traditional hydrogels are not sensitive to external changes, while environment-sensitive hydrogels can sense the outside world. Changes in the environment (such as temperature, mechanical force, s...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/04C08L1/08C08B37/04C08B15/06A61K9/06A61K47/36A61L27/26A61L27/52A61L27/50
CPCC08J3/075A61K9/06A61K47/36A61L27/26A61L27/50A61L27/52C08B15/06C08B37/0084C08J2301/08C08J2305/04C08J2401/08C08L1/08C08L5/04
Inventor 但卫华尤伟婷但年华崔国廉
Owner SICHUAN UNIV
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