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PH-sensitive self-repairing hydrogel and preparation method of same

A self-healing and hydrogel technology, applied in medical science, aerosol delivery, liquid delivery, etc., can solve problems such as self-healing, limited application in the field of biomedicine, and lack of self-healing performance, etc., achieving low cost, Wide source and good biocompatibility

Inactive Publication Date: 2017-07-14
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prepared material does not have self-healing properties, and cannot self-repair due to external environmental strain and stress loss, which limits its application in the field of biomedicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Preparation of dopamine-modified sodium alginate: Weigh a certain amount of sodium alginate, dissolve it in 2-(N-morpholine)ethanesulfonic acid (MES) buffer solution with a pH of 5.5, and prepare a mass concentration of 1% solution, and then dissolve 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) at a mass ratio of 5 In the above sodium alginate solution, react at 20°C for 40min, then add a certain mass proportion of dopamine, continue to stir and react for 24h at 20°C under the protection of nitrogen, then put it into a dialysis bag with a molecular weight cut-off of 3500Da, and dialyze with distilled water for 3 Days later, the retentate was taken and freeze-dried for 72 hours at a pressure of 10 Pa and a temperature of -50°C to prepare dopamine-modified sodium alginate;

[0023] (2) Preparation of 3-aminophenylboronic acid modified carboxymethyl cellulose sodium: Weigh a certain mass of carboxymethyl cellulose sod...

Embodiment 2

[0026] (1) Preparation of dopamine-modified sodium alginate: Weigh a certain amount of sodium alginate, dissolve it in 2-(N-morpholine)ethanesulfonic acid (MES) buffer solution with a pH of 6.5, and prepare a mass concentration of 2.5% solution, and then dissolve 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) at a mass ratio of 5 In the above sodium alginate solution, react at 25°C for 30min, then add a certain mass proportion of dopamine, continue to stir and react for 24h at 25°C under the protection of nitrogen, then put it into a dialysis bag with a molecular weight cut-off of 8000Da, and dialyze with distilled water for 3 Days later, the retentate was taken and freeze-dried for 72 hours at a pressure of 20 Pa and a temperature of -55°C to prepare dopamine-modified sodium alginate;

[0027](2) Preparation of 3-aminophenylboronic acid modified carboxymethyl cellulose sodium: Weigh a certain mass of carboxymethyl cellulose so...

Embodiment 3

[0030] (1) Preparation of dopamine-modified sodium alginate: Weigh a certain amount of sodium alginate, dissolve it in 2-(N-morpholine)ethanesulfonic acid (MES) buffer solution with a pH of 5.5, and prepare a mass concentration of 5% solution, and then dissolve 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) at a mass ratio of 2.5 In the above sodium alginate solution, react at 37°C for 20min, then add a certain mass proportion of dopamine, continue to stir and react for 24h at 37°C under the protection of nitrogen, then put it into a dialysis bag with a molecular weight cut-off of 8000Da, and dialyze with distilled water for 3 Days later, take the retentate and freeze-dry it for 60 hours at a pressure of 20 Pa and a temperature of -55°C to prepare dopamine-modified sodium alginate;

[0031] (2) Preparation of 3-aminophenylboronic acid modified carboxymethyl cellulose sodium: Weigh a certain mass of carboxymethyl cellulose sodiu...

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PUM

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Abstract

The invention discloses a pH-sensitive self-repairing hydrogel and a preparation method of same. The hydrogel is produced by crosslinking dopamine-modified sodium alginate and sodium carboxymethylcellulose modified by 3-aminophenylboronic acid according to a certain ratio, wherein the modified sodium alginate and sodium carboxymethylcellulose respectively have a catechol group and a phenylboronic acid group, so that between the two groups, a pH-sensitive phenylborate bond can be formed. The phenylborate bond is fractured if pH < 7 and is recovered if pH > 7, so that the hydrogel has a pH-responded self-repairing performance. A main raw material of the hydrogel is natural polysaccharide, so that the hydrogel has excellent biocompatibility and also has pH-responding property and self-repairing performance. The hydrogel has wide applications in the fields of controllable release of drugs, tissue engineering and the like.

Description

technical field [0001] The invention relates to a hydrogel with pH-sensitive self-healing property, good biocompatibility and proper expansion rate and a preparation method thereof, belonging to the field of preparation of biomedical materials. Background technique [0002] Hydrogel has a three-dimensional space network structure and is a hydrophilic cross-linked polymer that can absorb water and swell but is insoluble in water. Hydrogels are soft, can maintain a certain shape and have certain fluid properties, which is due to the fact that the hydrophilic groups in the hydrogel polymer can bind water and restrict the mobility of water. According to the different responses to external stimuli, hydrogels can be divided into traditional hydrogels and environment-sensitive hydrogels. Traditional hydrogels are not sensitive to external changes, while environment-sensitive hydrogels can sense the outside world. Changes in the environment (such as temperature, mechanical force, s...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/04C08L1/08C08B37/04C08B15/06A61K9/06A61K47/36A61L27/26A61L27/52A61L27/50
CPCC08J3/075A61K9/06A61K47/36A61L27/26A61L27/50A61L27/52C08B15/06C08B37/0084C08J2301/08C08J2305/04C08J2401/08C08L1/08C08L5/04
Inventor 但卫华尤伟婷但年华崔国廉
Owner SICHUAN UNIV
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