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A traditional Chinese medicine pill for treating diabetic nephropathy and its preparation method and application

A technology for diabetic nephropathy and traditional Chinese medicine pills, applied in the field of medicine, can solve problems such as inability to effectively prevent disease progression, controversial drug application, prone to hyperkalemia, etc., to improve the positive percentage of PAS staining, significantly resist cell oxidation, reduce The effect of renal HE staining on pathological scoring

Active Publication Date: 2020-10-30
CONSUN PHARML NEI MENG GU +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment methods of western medicine have solved the clinical problems such as high blood pressure and proteinuria in DKD patients to a certain extent, but none of them can effectively prevent the progression of the disease, and even lead to drug-induced nephropathy. The application of some drugs is still controversial, and hyperkalemia is prone to occur Syndrome, hypercreatinine and other side effects, during the use of blood potassium, serum creatinine levels need to be strictly monitored to limit its clinical use

Method used

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  • A traditional Chinese medicine pill for treating diabetic nephropathy and its preparation method and application
  • A traditional Chinese medicine pill for treating diabetic nephropathy and its preparation method and application
  • A traditional Chinese medicine pill for treating diabetic nephropathy and its preparation method and application

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preparation example Construction

[0036] (1) Preparation of traditional Chinese medicine pills

[0037] 1 test material

[0038] 1.1 Instrument

[0039] Traditional Chinese medicine multifunctional extraction and reflux concentration unit (Hunan Jinyifan Pharmaceutical Equipment Industry Co., Ltd., RZZ Xiang-082-06).

[0040] Multifunctional pellet coating machine (Shenzhen Xinyite Technology Co., Ltd., Mini-250).

[0041] 1.2 Raw and auxiliary materials

[0042] Astragalus (Bozhou Huikang Chinese Herbal Pieces Co., Ltd.);

[0043] Radix Puerariae (Bozhou Huikang Chinese Herbal Pieces Co., Ltd.);

[0044] Morus alba (Bozhou Huikang Chinese Herbal Pieces Co., Ltd.);

[0045] Ethanol (produced by Guangdong Shunguan Gas Solvent Co., Ltd.);

[0046] Microcrystalline cellulose (produced by Anhui Shanhe Pharmaceutical Excipients Co., Ltd.);

[0047] Starch (produced by Anhui Shanhe Pharmaceutical Excipients Co., Ltd.);

[0048] Dextrin (produced by Anhui Shanhe Pharmaceutical Excipients Co., Ltd.);

[0049] T...

Embodiment 1

[0052] Take 2.5kg of Radix Astragali, 5.0kg of Pueraria Radix, and 2.5kg of Cortex Mori, add 8 times the amount of 70% ethanol to reflux and extract twice, each time for 3 hours, filter, combine the filtrate, filter with a 50nm ceramic membrane, collect the filtrate, recover the ethanol and concentrate (Temperature: 70°C; Air pressure: -0.8~-0.6MPa) to a relative density of 1.32~1.35 (70°C), collect the paste for later use. Three parts were prepared in the same way: extract 1, extract 2 and extract 3.

[0053] Take the above three batches of extracts, add microcrystalline cellulose, starch and dextrin accounting for 40-60% of the total amount, respectively add 5% talcum powder as anti-sticking agent, mix well, add appropriate amount of water to make soft material, squeeze The process parameters of this step are: extrusion speed 35rpm, spheronization time 4min, spheronization speed 1000rpm. Dry at 60±10°C for 3 hours, pass through 18 and 24 mesh sieves, take the pellets that c...

Embodiment 2

[0056] Take 2.5kg of Radix Astragali, 5.0kg of Pueraria Radix, and 2.5kg of Cortex Mori, add 8 times the amount of 70% ethanol to reflux and extract twice, each time for 3 hours, filter, combine the filtrate, filter with a 50nm ceramic membrane, collect the filtrate, recover the ethanol and concentrate (Temperature: 70°C; Air pressure: -0.8~-0.6MPa) to a relative density of 1.32~1.35 (70°C), collect the paste for later use. Three parts were prepared in the same way: extract 1, extract 2 and extract 3.

[0057] Take the above three batches of extracts, respectively investigate the influence of microcrystalline cellulose, starch and dextrin on the yield of pellets, add 5% talcum powder as an anti-sticking agent, make the drug loading 50%, mix well, add Appropriate amount of water is used to make soft materials, extruded and spheronized into pellets, the process parameters of this step are: extrusion speed 35rpm, spheronization time 4min, spheronization speed 1000rpm. Dry at 60±...

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Abstract

The invention relates to a traditional Chinese medicinal pill for treating diabetic nephropathy as well as a preparation method and applications of the traditional Chinese medicinal pill. The active ingredient of the traditional Chinese medicinal pill is a traditional Chinese medicinal composition prepared by adopting radix astragali, radix puerariae and cortex mori, microcrystalline cellulose is adopted as a diluent, talcum powder is adopted as an anti-sticking agent, the drug loading capacity is high, the yield of the product is high, and the coating efficiency is high. The active ingredient of the traditional Chinese medicinal pill has the obvious effects of resisting cellular oxidation, resisting cell apoptosis and resisting cell membrane negative charge reduction, the dose-effect relationship is obvious, the structural barrier and charge barrier of the kidney cells can be effectively protected, and the traditional Chinese medicinal pill has the obvious effect of protecting the kidney.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine pill for treating diabetic nephropathy, a preparation method and application thereof. Background technique [0002] Diabetic kidney disease (DKD) is one of the most important microvascular complications of diabetes mellitus (DM) and the leading cause of end-stage renal disease (ESRD). Microangiopathy in diabetic nephropathy refers to glomerular sclerosis, which can be divided into three types: nodular, exudative and diffuse, and the three can exist alone or in combination. According to statistics, the number of DM patients in the world has reached 415 million at present, and it is expected to increase to 642 million in 2040, of which 20% to 45% of DM patients will develop DKD. The number of DM patients in my country has reached 110 million, and the incidence rate is increasing year by year. In 2012, 19% of ESRD patients in my country were cause...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/605A61K9/20A61K47/38A61P3/10A61P13/12
CPCA61K9/2054A61K9/2806A61K36/481A61K36/488A61K36/605A61K2236/333A61K2236/39A61K2300/00
Inventor 王汝上朱荃郑兆广胡琴何宝段婷婷黄晓玲黄寿义高俊飞范丽霞顾斐杨琳琳黄艳霞
Owner CONSUN PHARML NEI MENG GU