Method for compounding pyrroline derivative in one step by cyclizing and coupling suzuki

A technology for dihydropyrrole and derivatives, applied in chemical recovery, organic chemistry, etc., to achieve the effects of high yield, stable performance, and simple process
CN107056674AInactive Publication Date: 2017-08-18SHANDONG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
SHANDONG UNIV OF TECH
Publication Date
2017-08-18
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to a method for compounding a pyrroline derivative in one step by cyclizing and coupling suzuki and belongs to the field of chemical compounding of allene (1,2-propadiene) by cyclizing. The method is characterized in that (1) transition metal elements are adopted for catalyzing; (2) allene is used as a raw material for compounding; (3) the reaction is performed when the reaction temperature is low temperature or normal temperature; (4) the reaction is completed in one step; (5) the catalyst is fully recycled; (6) water is strictly removed from a reaction solvent and the trace level is achieved; (7) 2,3-pyrroline five-element ring is the main structure of the generated product; (8) the physical and chemical properties of the generated product are not changed under normal temperature and high temperature environments; (9) the yield of the generated product is more than or equal to 98 wt%; (10) the generated side products are easily removed according to a conventional method.
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Description

technical field

[0001] The method for synthesizing dihydropyrrole derivatives in one step through suzuki cyclization coupling belongs to the technical field of organic compound technology application. Background technique

[0002] Pyrrole derivative monomer is an important class of five-membered nitrogen heterocyclic compounds. Molecular materials and other fields have a wide range of applications. At present, the research on the total synthesis of natural cyclic tetrapyrrole compounds is a hot spot in the field of organic chemistry. One of the very important links is the construction of various substituted pyrrole monomer synthons. The difficulty of obtaining these pyrrole monomer synthons It is often a key factor in determining whether the reaction route is reasonable. Although many chemical synthesis methods of pyrrole derivatives have been developed, there are few reports on the single-molecule cyclic pyrrole compound produced by the one-step reaction of the end of the...

Claims

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