Spontaneous fluorescence and magnetic resonance bimodal molecular fusion small animal imaging system and method

Abstract

The invention relates to a spontaneous fluorescence and magnetic resonance bimodal molecular fusion small animal imaging system and a spontaneous fluorescence and magnetic resonance bimodal molecular fusion small animal imaging method. The spontaneous fluorescence and magnetic resonance bimodal molecular fusion small animal imaging system comprises a magnetic resonance small animal imaging module, a spontaneous fluorescence small animal imaging module, a jointing module and a system control module, wherein the magnetic resonance small animal imaging module comprises a magnetic resonance examination bed; the spontaneous fluorescence small animal imaging module is placed at the tail end of the magnetic resonance examination bed; the spontaneous fluorescence small animal imaging module detects optical signals through a CCD; the jointing module achieves one-stop information acquisition of a small animal between the spontaneous fluorescence imaging module and the magnetic resonance imaging module; the system control module is used for controlling the spontaneous fluorescence small animal imaging module, the magnetic resonance small animal imaging module and the jointing module and processing the acquired magnetic resonance and fluorescence data. Through the system and the method,spontaneous fluorescence and high-field magnetic resonance bimodal imaging is adopted to provide effective molecular imaging methods for detecting abnormality in cellular and molecular levels during lesion, exploring occurrence, development and metastasis of a tumor, monitoring a therapeutic process, evaluating the therapeutic effect of a medicine and the like.

Description

technical field [0001] The invention relates to the technical field of biomedical molecular imaging, in particular to a small animal autofluorescence and magnetic resonance dual-mode molecular fusion imaging system and method. Background technique [0002] Optical and magnetic dual-mode molecular fusion imaging is one of the cutting-edge molecular imaging technologies. After nearly ten years of development, molecular imaging technology has been widely recognized and valued for its application value and potential in the field of biomedicine, and it is generally recognized that this technology is one of the important links from basic to clinical transformation. [0003] At present, emerging molecular imaging technologies are emerging in an endless stream in the world. MR (magnetic resonance, magnetic resonance), as an increasingly widely used clinical imaging device, has incomparable advantages in reflecting the body's anatomical shape and physiological function information. ...

AI Technical Summary

Problems solved by technology

[0007] First, the magnetic compatibility of the optical system is poor;

[0008] Second, the magnetic resonance system has a low field strength, and the image resolution is difficult to meet the application research of subsequent biological experiments, and the magnetic resonance equipment needs to be modified;

[0009] Third, using optical fibers to detect optical signals on the surface of living organisms, the amount of measurement data is proportional to the number of fibers, so the amount of measurement data is limited, which is not conducive to reducing the pathological nature of optical tomography reconstruction problems

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