2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine compound inhibitors of beta-secretase

An organic light-emitting device and compound technology, applied in the field of organic light-emitting devices, can solve the problems of difficulty in practical application, high driving voltage, low efficiency, etc., and achieve the effect of achieving high efficiency and long life, ensuring low voltage driving and high efficiency

Pending Publication Date: 2017-08-29
DONGJIN SEMICHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, it is well known that there are various compounds of substances used in such organic light-emitting devices, but in the case of organic light-

Method used

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  • 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine compound inhibitors of beta-secretase
  • 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine compound inhibitors of beta-secretase
  • 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine compound inhibitors of beta-secretase

Examples

Experimental program
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preparation example Construction

[0248] Fabrication of Organic Light Emitting Devices

[0249] according to figure 1 The structure shown produces an organic light-emitting device. The organic light-emitting device is stacked sequentially from bottom to top with anode (hole injection electrode 11) / hole injection layer 12 / hole transport layer 13 / light emitting layer 14 / electron transport layer 15 / cathode (electron injection electrode 16).

[0250] The following substances were used for the hole injection layer 12, the hole transport layer 13, the light emitting layer 14, and the electron transport layer 15 of the examples and comparative examples.

[0251]

[0252] Before fabricating an organic light-emitting device, in order to observe that the energy formed by the exciplex is effectively transferred to the combination of host 1 and host 2 of the phosphorescent dopant, host 1 / host 2 (1:1) was evaporated on a glass substrate, and measured The exciplex wavelengths are shown in Table 1 below.

[0253] Table...

Embodiment 1

[0259] Ultrasonic cleaning with distilled water A glass substrate coated with a thin film of indium tin oxide (ITO). Once the distilled water cleaning is completed, ultrasonic cleaning and drying are performed with solvents such as isopropanol, acetone, and methanol, and then transferred to a plasma cleaner. After cleaning the above-mentioned substrate with oxygen plasma for 5 minutes, use a thermal evaporation coater (thermalevaporator). With hole injection layer HI01 Hole transport layer, on top of ITO substrate, with NPB Make a film. Afterwards, as the above-mentioned light-emitting layer, doping compound 1-1 / Ir(ppy) 3 10% to Make a film. Then, as the electron transport layer, with ET01:Liq(1:1) After film formation, LiF Aluminum (Al) A film was formed, and the device was sealed (encapsulated) in a glove box, thereby producing a green organic light-emitting device.

Embodiment 2

[0261] A green organic light-emitting device was fabricated by the same method except that Compound 1-2 was used as the host of the light-emitting layer in Example 1 above instead of Compound 1-1.

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Abstract

The present invention relates to 2,3,4,5-tetrahydropyridin-6-amine and 3,4- dihydro-2H-pyrrol-5-amine compound inhibitors of beta-secretase having the structure shown in Formula (I), wherein the radicals are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease, dementia associated with beta- amyloid, age-related macular degeneration, type 2 diabetes or metabolic disorders.

Description

technical field [0001] The present invention relates to novel compounds and organic light-emitting devices comprising them. Furthermore, the present invention relates to an organic light-emitting device in which the above-mentioned novel compound and a carbazole derivative are used together as a host, thereby appropriately adjusting the wavelength of the exciplex and maximizing the efficiency and lifetime. Background technique [0002] Recently, organic light-emitting devices capable of self-luminous low-voltage drive are superior in viewing angle and contrast ratio compared with liquid crystal displays (LCDs) which are the mainstream of flat panel display devices, and do not require a backlight. Lightweight and thinner, it is also advantageous in terms of power consumption, and it has a wide range of color reproduction, so it is attracting attention as a next-generation display device. [0003] In organic light-emitting devices, materials used as organic layers can be roug...

Claims

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Application Information

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IPC IPC(8): C07D405/04C07D405/14C07D409/04C07D409/14C09K11/06H01L51/54
CPCC07D405/04C07D405/14C07D409/04C07D409/14C09K11/06C09K2211/1092C09K2211/1088C09K2211/1059C09K2211/1044C09K2211/1029H10K85/622H10K85/654H10K85/6576H10K85/6574C09B57/00C09B57/10H10K85/342H10K50/11H10K2101/10H10K2101/90
Inventor 咸昊完金奉记金成勋安贤哲金熙宙金东骏李萤振林东焕安慈恩
Owner DONGJIN SEMICHEM CO LTD
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