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Polymeric hydrogel embolic microsphere coated with drug loading nano material as well as preparation method and application of polymeric hydrogel embolic microsphere

A polymer hydrogel and drug-loaded nanotechnology, applied in the field of microspheres, can solve the problems of inability to perform secondary embolization, degradation, lipiodol difficulty, etc., achieve good tumor treatment effect, improve treatment effect, and increase drug concentration Effect

Inactive Publication Date: 2017-09-22
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patents 028179676 and 018236316 describe a method of using paclitaxel oily composition to improve the solubility of drugs in lipiodol. The problem is that lipiodol is difficult to degrade in the body and cannot be used for secondary embolization.
[0004] Therefore, after the nano-medicine in the prior art enters the human body, there are defects such as high loss, poor utilization rate, and unsatisfactory expected effect.

Method used

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  • Polymeric hydrogel embolic microsphere coated with drug loading nano material as well as preparation method and application of polymeric hydrogel embolic microsphere
  • Polymeric hydrogel embolic microsphere coated with drug loading nano material as well as preparation method and application of polymeric hydrogel embolic microsphere
  • Polymeric hydrogel embolic microsphere coated with drug loading nano material as well as preparation method and application of polymeric hydrogel embolic microsphere

Examples

Experimental program
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Effect test

Embodiment 1

[0032] The preparation method of cross-linked polymer hydrogel microspheres:

[0033] The first step is to build a microfluidic microdroplet generating device: select a T-shaped microfluidic chip with a hydrophobic inner wall, a dual-channel syringe pump, and a heating device to build a microfluidic system;

[0034] The second step is to prepare the continuous phase and dispersed phase:

[0035] Continuous phase (oil phase): liquid paraffin containing 4% Span 80;

[0036] Dispersed phase (water phase): an aqueous solution containing 10% gelatin, heated to 45°C using a microfluidic temperature control device;

[0037]In the third step, the flow rate of the continuous phase is adjusted to the maximum allowed by the built microfluidic system of 2.5mL / h, so as to achieve the maximum output rate of microspheres. Control the flow rate of the aqueous phase to 0.056mL / h to form monodisperse droplets in the microchannel. After the microspheres flow out of the microchannel, it is at r...

Embodiment 2

[0041] Preparation method of polymer hydrogel microspheres containing graphene nanomedicine:

[0042] The first step is to build a microfluidic microdroplet generating device: select a T-shaped microfluidic chip with a hydrophobic inner wall, a dual-channel syringe pump, and a heating device to build a microfluidic system;

[0043] The second step is to prepare the continuous phase and dispersed phase:

[0044] Continuous phase (oil phase): liquid paraffin containing 4% Span 80;

[0045] Dispersed phase (aqueous phase): an aqueous solution containing 10% gelatin, to which 2mg / mL nanomedicine (DOX@GO) was added (refer to Yang, X.Y., et al., High-Efficiency Loading and Controlled Release of Doxorubicin Hydrochloride on Graphene Oxide. Journal of Physical Chemistry C, 2008.112(45):p.17554-17558.), using a microfluidic temperature control device to heat to 45°C;

[0046] In the third step, the flow rate of the continuous phase is adjusted to the maximum allowed by the built micr...

Embodiment 3

[0054] Similar to Example 2, but wherein the nano-medicine loaded with irinotecan is used to obtain hydrogel microspheres encapsulating the nano-medicine;

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Abstract

The invention discloses a nano drug-supported embolic microsphere with a controllable particle size as well as preparation method and application of the embolic microsphere. According to the hydrogel embolic microsphere, loss of the nano drug in the intravascular delivery process is avoided, the nano drug is targeted at tumor tissues to be released through an intervention method by utilizing the embolic microsphere with the controllable particle size, the utilization rate of the nano drug is greatly improved, and dual effects of nano drug chemotherapy and embolism blocked tumor blood supply can be achieved. The preparation method and process in the invention are simple and reliable, and monodisperse embolic microspheres with specific size can be prepared as required.

Description

technical field [0001] The invention relates to a polymer hydrogel embolic microsphere wrapped with drug-loaded nanomaterials, a preparation method and application thereof, and belongs to the technical field of microspheres. Background technique [0002] Nanomedicine has good animal experiment results in in vitro research, but it still fails to achieve the expected effect after entering the human body. The main reason is that nanomedicine is interfered by the human immune system after entering the human circulation, and it is difficult to exert the excellent performance of nanomedicine. After intravenous injection into the human body, nanomedicine needs to go through multiple steps such as blood circulation, crossing the blood vessel wall, and penetrating into tumor tissue. However, it is consumed in large quantities during the blood circulation process, and the proportion of drugs actually utilized by tumor tissue is extremely low. [0003] The invention with the publicatio...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/08A61L24/02A61L24/00A61K9/16A61K9/06A61K47/42A61K47/36A61K47/02A61K31/704A61K31/4745A61P35/00C08J3/24C08J3/075
CPCA61K47/02A61K47/36A61K47/42A61L24/001A61L24/0015A61L24/0031A61L24/0042A61L24/02A61L24/08A61L24/104A61L24/108A61K9/06A61K9/16A61K31/4745A61K31/704C08J3/075C08J3/24A61L2400/12A61L2300/416A61L2300/418C08J2305/08C08J2389/00C08L5/08
Inventor 张弢王常煜覃宇
Owner NANJING UNIV
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