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Traditional Chinese medicine compound microemulsion gel and preparation method and application thereof

A technology of microemulsion gel and microemulsion, which is applied in the direction of pharmaceutical formulations, non-central analgesics, antipyretics, etc., can solve the problems of skin residues, pollution, energy resource consumption, etc., to facilitate release and transdermal Absorption, Reduces Allergic Reactions, Enhances Therapeutic Effects

Inactive Publication Date: 2017-11-07
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional preparation methods of rubber plaster mainly include solvent method and hot pressing method, both of which need to be completed at a higher temperature, which will inevitably cause the loss of active ingredients and affect the efficacy of the drug.
And the solvent method consumes a large amount of energy resources, the production process safety hazard is big, gasoline is very easy to burn, and a large amount of volatilization of gasoline in the drying process pollutes the environment, and is also unfavorable for the labor protection of production workers; Bright, weak stickiness, residues on the skin after pasting, etc.

Method used

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  • Traditional Chinese medicine compound microemulsion gel and preparation method and application thereof
  • Traditional Chinese medicine compound microemulsion gel and preparation method and application thereof
  • Traditional Chinese medicine compound microemulsion gel and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1 Preparation of Huoxue Zhitong Extract

[0070] Huoxue Zhitong ointment (rubber ointment) has been included in the Pharmacopoeia (2010 edition, one part 957 pages, 2015 edition one part, 1294 pages), its prescription and extract preparation method are as follows:

[0071]

[0072] In addition to menthol, borneol, camphor, methyl salicylate, and belladonna liquid extract in the above prescription, the other twenty-three medicinal materials such as Angelica dahurica are crushed into coarse powder, and 90% ethanol is used as a solvent, soaked, percolated, and collected. The percolation solution is recovered from ethanol and concentrated into a clear paste with a relative density of 1.2634 (25° C.), and the belladonna fluid extract is added and stirred evenly to obtain the extract of traditional Chinese medicine. Above-mentioned menthol, borneol, camphor, methyl salicylate, menthol are standby.

Embodiment 2

[0073] Embodiment 2 The preparation example 1 of microemulsion gel for promoting blood circulation and relieving pain of the present invention

[0074] Prescription 1 (according to 100 grams)

[0075]

[0076] Weigh menthol, borneol, camphor, and methyl salicylate according to the prescription in Example 1, first take camphor, menthol, and borneol, mix and grind until partially liquefied, then add methyl salicylate and stir to completely dissolve, as a mixed oil phase .

[0077] Weigh 1.15g of the mixed oil phase, 9.30g of RH40, 4.63g of PEG400, and 0.075g of potassium sorbate and stir for 10 minutes at 20-35°C at a stirring speed of 300-500 rpm, slowly add water, and stir for 10 minutes to balance. Add 1.75 g of the traditional Chinese medicine extract extract prepared in Example 1, stir and balance for 30 minutes, and obtain the microemulsion for promoting blood circulation and relieving pain.

[0078] Then weigh 1.00g of carbomer and 0.05g of edetate disodium, add approp...

Embodiment 3 preparation example 2

[0080] Prescription 2 (according to 100 grams)

[0081]

[0082] Weigh menthol, borneol, camphor, and methyl salicylate according to the prescription in Example 1, first take camphor, menthol, and borneol, mix and grind until partially liquefied, then add methyl salicylate and stir to completely dissolve, as a mixed oil phase .

[0083] Weigh 3.50 g of the Chinese medicine extract prepared in Example 1, 2.30 g of the mixed oil phase, 13.88 g of Tween 80, and 4.62 g of absolute ethanol, and stir at 20-35°C for 40 minutes at a stirring speed of 300-500 rpm After the drug is completely dissolved, slowly add an appropriate amount of water, stir and balance for 20 minutes to obtain blood circulation and pain-relieving microemulsion.

[0084] Then weigh 2.50g of CMC-Na and 0.10g of disodium edetate, add the blood-activating and pain-relieving microemulsion prepared above, fully swell overnight at 20-35°C, add 5.00g of propylene glycol, stir evenly, and the stirring speed is 150-...

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Abstract

The invention relates to a traditional Chinese medicine compound microemulsion gel and its preparation method and application. In particular, the present invention relates to a microemulsion gel composition, which contains methyl salicylate, menthol, camphor, borneol and traditional Chinese medicine extracts containing paeonol, eugenol, piperine and other active ingredients, and micro An emulsion gel matrix, wherein the active ingredient is entrapped in a microemulsion. The present invention further relates to the preparation method of the microemulsion gel composition and its use in promoting blood circulation and relieving pain. The preparation of the invention not only ensures the high degree of fusion of the drug and the matrix, but also has the characteristics of high drug loading, low irritation to the skin, good transdermal absorption performance, simple preparation process and the like.

Description

technical field [0001] The invention provides a novel microemulsion gel preparation, its preparation method and its application in medicine. Background technique [0002] The prescription of Huoxue Zhitong Ointment comes from the "Baozhen Ointment" in the seventh year of Emperor Kangxi of the Qing Dynasty. It was independently developed and produced by Anhui Anke Yu Liangqing Pharmaceutical Co., Ltd. It was changed to a rubber ointment formulation in 1965 and has a sales history of more than 50 years. Huoxue Zhitong Ointment was included in the "Chinese Pharmacopoeia" in 2010, and it is recorded that it has the effect of promoting blood circulation and relieving pain, relaxing tendons and dredging collaterals, and is used for muscle and bone pain, muscle paralysis, phlegm nucleus flow, and joint pain. Due to its definite curative effect, it has been widely recognized by patients since its launch, and the annual single variety exceeds 100 million yuan. [0003] The prescript...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/107A61K9/06A61P29/00
CPCA61K36/9068A61K9/06A61K9/1075A61K36/232A61K36/236A61K36/268A61K36/27A61K36/284A61K36/324A61K36/328A61K36/538A61K36/54A61K36/575A61K36/61A61K36/65A61K36/67A61K36/708A61K36/71A61K36/752A61K36/81A61K36/84A61K36/8884A61K36/8888A61K36/906A61K47/10A61K47/26
Inventor 刘淑芝何爱萍刘道芳易红梁日欣杜茂波冯伟红刘海兵姚瑶柏金金徐莉莉
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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