Programmable control micro-fluidic chip based on liquid-liquid electrowetting effect

Abstract

The invention provides a programmable control micro-fluidic chip based on a liquid-liquid electrowetting effect. The programmable control micro-fluidic chip comprises a lower substrate, a drive electrode array, a lower substrate hydrophobic insulating layer, at least one liquid drop, an upper substrate hydrophobic layer, a conductive layer and an upper substrate from bottom to top, wherein cofferdams are added to the peripheries of the upper substrate and the lower substrate to form a closed cavity. The hydrophobic insulating layer is formed by a porous polymer film and a liquid capable of improving electric wettability and has the advantages of being good in electric wetting reversibility, reusable and resistant to voltage breakdown, high temperature and chemical reagents, the effect of the hydrophobic insulating layer is not affected after long-time storage, so that the service life of a device is prolonged, the efficiency of the device is improved, and the application range of the device is broadened; besides, the pressing mode of the drive electrode array can be programmed, therefore, operation processes such as rapid movement, combination, reaction and the like of different liquid drops are executed in different positions according to preset parameters.

Description

technical field [0001] The invention relates to the technical field of digital microfluidics, and more specifically, to a programmable control microfluidic chip based on the liquid-liquid electrowetting effect. Background technique [0002] Digital microfluidic chip refers to the laboratory on chip (Labon chip) that uses microfluidic technology to manipulate discrete tiny droplets. In recent decades, it has developed rapidly in laboratory research, industrial applications, and life applications. Preparation, reaction, separation, detection and other operations are concentrated on a chip of a few square centimeters, which has the characteristics of low energy consumption, less reagents required, rapid response, fast response, and precision, and is widely used in biochemical analysis and detection, micro-reactions, etc. field. [0003] The digital microfluidic chip based on the electrowetting effect on the medium mainly includes upper and lower substrates, dielectric layers, ...

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Problems solved by technology

[0003] The digital microfluidic chip based on the electrowetting effect on the medium mainly includes upper and lower substrates, dielectric layers, driving electrodes, hydrophobic layers, etc. The dielectric layer is the insulating layer, and the dielectric layer and the hydrophobic layer can be the same substance, that is, the material It has insulating and hydrophobic properties at the same time. At present, the widely used insulating and hydrophobic layer materials mainly include Teflon AF, Cytop, Hyflon, and polysiloxane imide. Most of these materials are easy to be broken down, so another material is usually selected As a dielectric layer, and then coated with a hydrophobic layer, for example, the patent CN 103592759 uses silicon dioxide as an insulating layer, TeflonAF2400, Parylene, polyimide, PMMA and other materials as hydrophobic materials, that is, making a hydrophobic insulating layer requires two Generally, the film-forming process requires heating, which requires high temperature resistance for device materials, which undoubtedly increases the cost of device manufacturing. The hydrophobic layer material used is easily polluted or damaged after repeated experiments, shortening the life of the device. Even cause the entire device to be scrapped

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