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Endoconcha Sepiae-based oxytocin embedded preparation

A sea octopus and preparation technology, which is applied in the field of oxytocin embedding preparations, can solve the problems of low microcapsule coating rate and small practicability, and achieve the effects of good embedding effect, structure protection and strength improvement

Active Publication Date: 2017-11-21
ZHEJIANG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Prior art, such as the Chinese invention patent with the authorized announcement number CN 103142551 B, discloses a method for preparing microcapsules by using xanthan gum and gelatin as the wall material complex coacervation method. In this method, the core material is wrapped in the coacervated phase of the wall material. In the middle, the contact between the core material and oxygen is isolated, and the storage time of the core material drug is improved, but the coating rate of the microcapsule is low, and the practicability is small

Method used

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  • Endoconcha Sepiae-based oxytocin embedded preparation

Examples

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Effect test

Embodiment 1

[0012] A kind of oxytocin embedding preparation based on squid cuttlebone octopus, the preparation method is as follows: firstly, the preparation of the core material: take the container, add 900 parts of distilled water, then add 10 parts of chitosan quaternary ammonium salt, stir for 15 minutes until uniform, and then Weigh 0.1 parts of gonadotropin-releasing hormone and add it to the container, stir for 10 minutes, then add 5 parts of azodicarbonamide, stir for 4 minutes, then add 2 parts of sodium tripolyphosphate, stir for 30 minutes, set the relative centrifugal force of the centrifuge to 2000g, After centrifuging for 35 min, the resulting solid mixture was freeze-dried to obtain a core material. Chitosan quaternary ammonium salt has high adhesion and good biocapacity, which can strongly improve the permeability of cell membranes and increase the absorption of oxytocin by squid; the addition of azodicarbonamide improves the strength of the core material , which is benefi...

Embodiment 2

[0014] An oxytocin embedding preparation based on squid cuttlebone, the preparation method of which is as follows:

[0015] 1) Preparation of core material: Take 15 parts of chitosan quaternary ammonium salt, add 1000 parts of distilled water, stir evenly, then add 0.2 parts of gonadotropin-releasing hormone, stir for 15 minutes, then add 7 parts of azodicarbonamide, Stir for 6 minutes, then add 3 parts of sodium tripolyphosphate, stir for 35 minutes, centrifuge at a relative centrifugal force of 2000g for 35 minutes, and freeze-dry the obtained solid mixture to obtain a core material. Chitosan quaternary ammonium salt has high adhesion and good biocapacity, which can strongly improve the permeability of cell membranes and increase the absorption of oxytocin by squid; the addition of azodicarbonamide improves the strength of the core material , which is beneficial to protect the structure of hormones;

[0016] 2) Preparation of microcapsules: Add 12 parts of β-cyclodextrin to...

Embodiment 3

[0018] An oxytocin embedding preparation based on squid cuttlefish octopus, the preparation method is as follows: Compared with Example 2, the inner wall of the polyvinylidene chloride reactor in this example is not provided with a coating, and other conditions are the same.

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Abstract

The invention discloses an Endoconcha Sepiae-based oxytocin embedded preparation. A chitosan quaternary ammonium salt reacts with oxytocin to prepare a core material, and the core material reacts with a wall material comprising beta-cyclodextrin and maltodextrin in a polyvinylidene chloride reaction kettle to prepare microcapsules. The prepared capsules have the advantages of large quantity, uniform in particle size distribution, high cladding rate and good embedding effect; the addition of azodicarbonamide in the preparation process of the core material increases the strength of the core material and facilitates the protection of the structure of oxytocin; gonadotrophin releasing hormones can promote the division of oocytes and rapidly ripen cuttlefishes, and are safe and harmless; and the arranged inner wall coating of the reaction kettle promotes of holes formed by the entrance of the core material to the beta-cyclodextrin, and increases the quantity of hydrophobic bonds.

Description

technical field [0001] The invention relates to the field of artificial ripening, in particular to an oxytocin embedding preparation based on squid cuttlefish and octopus. Background technique [0002] Squid was once one of the four major fisheries in my country's fishing grounds. It has strong adaptability to temperature and is widely distributed in my country's coastal areas. It is a traditional fishery species with high economic value. Due to overfishing and ecological deterioration, since the 1970s, there have been successive declines. In recent years, the breeding and multiplication of squid has started in China, and the development momentum is good. However, the artificial breeding of squid still relies on its own reproduction and spawning, and the method of artificial induction and ripening has not yet been formed, which is not conducive to the scale of squid development of the breeding and farming industry. Among them, the pros and cons of hormone-embedded preparat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/09A61K9/50A61K47/40A61K47/36A61K47/18A61P15/08A61P3/00
CPCA61K9/5036A61K38/09A61K47/18A61K47/36
Inventor 龚理庞赞吕振明王天明刘立芹于新秀吴常文
Owner ZHEJIANG OCEAN UNIV
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