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Disposable composite drug-coated coronary bougie

A technology of drug coating and coronary artery, applied in the field of medical devices, can solve the problems of no anastomosis position, insufficient blood supply of diseased branches, etc., and achieve the effect of convenient administration and high drug concentration

Active Publication Date: 2020-06-02
BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 4. Intimal detachment injury: For patients with diffuse coronary artery lesions (lesion length > 1cm, lumen < 1mm) or severe coronary artery calcification, traditional bypass surgery sometimes cannot find a suitable anastomotic location, resulting in lesions branching. Insufficient blood supply, when coronary intimal stripping provides a viable anastomotic site for complete revascularization
Although the suture production process has been improved in recent years, and the doctor's vascular suture technique has improved the long-term patency rate after bypass surgery to a certain extent, but the four key factors that cause postoperative restenosis cannot be fundamentally avoided.

Method used

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  • Disposable composite drug-coated coronary bougie
  • Disposable composite drug-coated coronary bougie

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation steps are:

[0035] 1. Preparation of heparin+fluvastatin PLGA microspheres

[0036] ① Dissolve 30mg of polylacticcoglycolic acid (polylacticcoglycolic acid, PLGA, 50:50) in 2mL of dichloromethane (DCM),

[0037] ② Add 400 μL of heparin + fluvastatin solution (200 mg of heparin and 300 mg of fluvastatin) into the above-mentioned PLGA-dissolved DCM in an ice bath, and ultrasonicate for 30 s to form a primary emulsion.

[0038] ③ Add the sonicated colostrum into 30 mL of 2% polyvinyl alcohol (PVA) aqueous solution and sonicate for 2 minutes to form a double emulsion

[0039] ④Stir the complex emulsion at room temperature for 12 hours with a magnetic sub, fully volatilize and remove DCM,

[0040] ⑤ Ultracentrifuge 3 times with double distilled water, wash away residual PVA and unwrapped plasmid, resuspend with double distilled water,

[0041] ⑥ Freeze-dry in a freeze dryer for 24 hours to make compound drug-loaded PLGA particles.

[0042] 2. Preparation...

Embodiment 2

[0049] Embodiment 2 bougie electroplating

[0050] The bougie consists of a bougie handle 1, a deformable wire 2 and a stainless steel probe 3. The bougie handle 1 is convenient for users to hold, and has a length of about 3 cm. In order to reduce costs, it is made of plastic. The stainless steel bougie probe 3 of this embodiment has a length of 1 cm, a diameter of 1 mm, and is non-deformable. The operation of the bougie carrying the composite drug PLGA particles is the same as that in Example 1.

[0051] Place the probe of the stainless steel bougie in acetone, ethanol, and desalinated water in sequence, shake and clean it under ultrasonic waves, and then immerse it in a nanoparticle solution with a concentration of 50mg / ml. Use a DC power supply at 5mA for 10 minutes of electroplating. After the electroplating is completed , rinse the probe with desalinated water, and dry overnight under vacuum.

[0052] The paclitaxel coating material formula is 100mg paclitaxel powder+9...

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Abstract

The invention provides a disposable coronary artery bougie with a compound medicine coating. The compound medicine coating is plated on the surface of a probe of the coronary artery bougie and includes the following effective components: heparin, taxol and fluvastatin. The invention also provides preparation and application of the disposable coronary artery bougie with the compound medicine coating. In the bougie with the compound medicine coating, the medicines carried on nanoparticles of the coating are determined according to the pathological characters of restenosis at an anastomotic stoma after coronary artery bypass grafting. On the basis of three mechanisms including thrombosis during perioperative period, postoperative short-term endometrial hyperplasia and postoperative long-term coronary atherosclerotic restenosis, the three medicines, heparin, taxol and fluvastatin, carried on the nanoparticles are determined, so that the compound medicine coating can cooperatively solve the problem of perioperative restenosis.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a drug-loaded surgical device, its preparation and application. Background technique [0002] Coronary atherosclerotic heart disease is currently a relatively serious disease that threatens human health, and coronary artery bypass grafting (CABG, also known as coronary artery bypass grafting) is one of the important methods for treating this disease. The restenosis of graft vessels after coronary artery bypass grafting is the main factor affecting the curative effect of CABG. Studies have shown that the patency rates of 1 year, 5 years and 10 years after bypass surgery are 93%, 74% and 41% respectively. Artery) and the anastomosis of the coronary artery and the distal position of the anastomosis. The specific reasons are as follows: [0003] 1. Surgical injury: First of all, in order to facilitate the operation and expose the surgical field of view, the surgeon will ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/16
CPCA61L31/16A61L2300/216A61L2300/232A61L2300/416A61L2300/45A61L2300/606A61L2300/624A61L2420/02
Inventor 于洋高铭鑫于文渊王鹏程唐田
Owner BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV