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Platycodon grandiflorum phytosterol with anti-aging and anti-inflammatory activity and preparation method and application thereof

A phytosterol, anti-aging technology, applied in the direction of medical preparations containing active ingredients, anti-inflammatory agents, plant raw materials, etc., can solve the problem of unretrieved bellflower residues, etc., to help small wounds heal, with high content, and maintain integrity sexual effect

Inactive Publication Date: 2018-01-05
GUANGZHOU JUZHU GENERAL TECH INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, no relevant records have been found on the extraction method or patent application of bellflower residue

Method used

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  • Platycodon grandiflorum phytosterol with anti-aging and anti-inflammatory activity and preparation method and application thereof
  • Platycodon grandiflorum phytosterol with anti-aging and anti-inflammatory activity and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A method for preparing platycodon phytosterols with anti-aging and anti-inflammatory activities, comprising the following steps:

[0026] (1) Put the platycodon root residue in a thermostat at 32.5°C, add yeast powder as a nitrogen source under ventilated and aerobic conditions, add Aspergillus oryzae suspension and mix well, ferment together, and collect fermentation samples; The conditions are: a solid-state aerobic fermentation method, a strain inoculation amount of 3mL / 100g, a fermentation time of 4.5 days, a fermentation temperature of 32.5°C, and a nitrogen source addition of 3.5%.

[0027] (2) After the fermentation finishes, take out the sample, pulverize after drying, and obtain the fermented Platycodon grandiflorum residue powder of crossing 50 mesh sieves;

[0028] (3) Weigh the fermented Platycodon grandiflorum residue powder, add 75% ethanol solution according to the ratio of solid to liquid 1:25, carry out reflux extraction 3 times, each time for 1h, combi...

Embodiment 2

[0031] A method for preparing platycodon phytosterols with anti-aging and anti-inflammatory activities, comprising the following steps:

[0032] (1) Put the platycodon root residue in an incubator at 30°C, add yeast powder as a nitrogen source under ventilated and aerobic conditions, add Aspergillus oryzae suspension and mix well, ferment together, and collect fermentation samples; The conditions are: a solid-state aerobic fermentation method, a strain inoculum amount of 3mL / 100g, a fermentation time of 4.5 days, a fermentation temperature of 30°C, and a nitrogen source addition of 3.5%.

[0033] (2) After the fermentation finishes, take out the sample, pulverize after drying, and obtain the fermented platycodon grandiflorum residue powder of crossing 40 mesh sieves;

[0034] (3) Weigh the fermented Platycodon grandiflora residue powder, add 70% ethanol solution according to the ratio of solid to liquid 1:25, carry out reflux extraction 3 times, each time for 1h, combine the e...

Embodiment 3

[0037] A method for preparing platycodon phytosterols with anti-aging and anti-inflammatory activities, comprising the following steps:

[0038] (1) Put the platycodon root residue in an incubator at 35°C, add yeast powder as a nitrogen source under ventilated and aerobic conditions, add Aspergillus oryzae suspension and mix well, ferment together, and collect fermentation samples; The conditions are: a solid-state aerobic fermentation method, a strain inoculum amount of 3mL / 100g, a fermentation time of 4.5 days, a fermentation temperature of 35°C, and a nitrogen source addition of 3.5%.

[0039] (2) After the fermentation finishes, take out the sample, pulverize after drying, and obtain the fermented Platycodon grandiflorum residue powder of crossing 60 mesh sieves;

[0040] (3) Weigh the fermented Platycodon grandiflorum residue powder, add 80% ethanol solution according to the ratio of solid to liquid 1:25, carry out reflux extraction 3 times, each time for 1h, combine the ...

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Abstract

The invention discloses platycodon grandiflorum phytosterol with anti-aging and anti-inflammatory activity and a preparation method and application thereof. The method includes the steps of (1) placing platycodon grandiflorum residues in an incubator at 30-35 DEG C, adding yeast powder as a nitrogen source under ventilated aerobic conditions, adding an aspergillus oryzae suspension to mix evenly,conducting fermentation together, and collecting a fermentation sample; (2) after fermentation, taking the sample out, and smashing after drying to obtain fermented platycodon grandiflorum residue powder; (3) weighting the fermented platycodon grandiflorum residue powder, adding organic solvent according to 1:2 of solid-liquid ratio, conducting backflow to extract by 3 times, lasting for 1 h eachtime, merging extracted solutions, filtering, conducting rotary evaporation concentration and freeze drying on obtained filter liquor, and obtaining the crude extracted object of platycodon grandiflorum residues; (4) conducting adsorption, elution and purification on the crude extracted object of platycodon grandiflorum residues by using macroporous resin, and obtaining the phytosterol. The platycodon grandiflorum phytosterol prepared by the method is high in content and stable in performance, can be added into multiple skin care products, and has the anti-aging and anti-inflammatory functions.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to platycodon platycodon phytosterol with anti-aging and anti-inflammation activities, its preparation method and application. Background technique [0002] With the growth of age, there are too many free radicals in the body, or external environmental factors such as ionizing radiation, oxidative environment, pollution, etc. cause a large amount of free radicals to accumulate, thus aging and aging the skin. Aging will inevitably involve changes in membrane structure. Membrane lipid structure is a key substance of membrane structure, which includes three types of lipids: phospholipids, glycolipids, and sterols, of which sterols play a role in the membrane structure. When the membrane is aging or defective, the long chains of fatty acid hydrocarbon groups in the bilayer membrane lose their ability to swing freely, and the phospholipid molecules also lose their degree of freedom, their positi...

Claims

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Application Information

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IPC IPC(8): A61K8/63A61K8/9789A61Q19/08A61Q19/10A61Q19/00A61K36/346A61P29/00A61P17/18
Inventor 不公告发明人
Owner GUANGZHOU JUZHU GENERAL TECH INST CO LTD