Preparation method of paracetamol-loaded nanofiber composite material

A paracetamol and nanofiber technology, which is used in cellulose raw material pulping, fiber raw material processing, medical preparations with non-active ingredients, etc., to achieve the effects of optimizing production efficiency, protecting the ecological environment, and ensuring stability

Active Publication Date: 2020-07-17
GUANGXI TEACHERS EDUCATION UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surprisingly, composite parts with natural fibers such as flax, jute, and ramie as reinforcements have appeared, and gratifying progress has been made in environmental protection. Banana fiber needs further research

Method used

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  • Preparation method of paracetamol-loaded nanofiber composite material
  • Preparation method of paracetamol-loaded nanofiber composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation method of the nanofiber composite material loaded with acetaminophen is characterized in that it comprises the following steps: the nanofiber composite material is obtained through grafting reaction between the nanofiber and ε-caprolactone, and 10 parts by weight of the nanofiber The composite material was dissolved in 80 parts by weight of acetonitrile under the action of ultrasound to obtain the first mixed solution, and 1 part by weight of acetaminophen was dissolved in 80 parts by weight of tetrahydrofuran under the action of ultrasound to obtain the second mixed solution. After the first mixed solution is mixed with the second mixed solution, a third mixed solution is obtained, and the third mixed solution is volatilized and dried to obtain acetaminophen-loaded nanofiber composite material;

[0033]Described nanofiber is banana cellulose nanofiber, and it is made by following steps:

[0034] S1. Peel and slice the banana stems, dry them for 5 days, ...

Embodiment 2

[0039] The preparation method of the nanofiber composite material loaded with acetaminophen is characterized in that it comprises the following steps: the nanofiber composite material is obtained through grafting reaction between the nanofiber and ε-caprolactone, and 35 parts by weight of the nanofiber The composite material was dissolved in 80 parts by weight of acetonitrile under the action of ultrasound to obtain the first mixed solution, and 3 parts by weight of acetaminophen was dissolved in 80 parts by weight of tetrahydrofuran under the action of ultrasound to obtain the second mixed solution. After the first mixed solution is mixed with the second mixed solution, a third mixed solution is obtained, and the third mixed solution is volatilized and dried to obtain acetaminophen-loaded nanofiber composite material;

[0040] Described nanofiber is banana cellulose nanofiber, and it is made by following steps:

[0041] S1. Peel and slice the banana stems, put them in concent...

Embodiment 3

[0047] The preparation method of the nanofiber composite material loaded with acetaminophen is characterized in that it comprises the following steps: the nanofiber composite material is obtained through grafting reaction between the nanofiber and ε-caprolactone, and 25 parts by weight of the nanofiber The composite material was dissolved in 80 parts by weight of acetonitrile under the action of ultrasound to obtain the first mixed solution, and 2 parts by weight of acetaminophen was dissolved in 80 parts by weight of tetrahydrofuran under the action of ultrasound to obtain the second mixed solution. After the first mixed solution is mixed with the second mixed solution, a third mixed solution is obtained, and the third mixed solution is volatilized and dried to obtain acetaminophen-loaded nanofiber composite material;

[0048] Described nanofiber is banana cellulose nanofiber, and it is made by following steps:

[0049] S1. Peel and slice the banana stems, dry them in the air...

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Abstract

The invention discloses a preparation method of a paracetamol-loaded nano-fiber composite material. The method comprises the following steps: performing grafting reaction on nano-fiber and epsilon-caprolactone to obtain a nano-fiber composite material; dissolving 10 to 35 parts by weight of nano-fiber composite material in 80 parts by weight of acetonitrile under an ultrasonic action to obtain a first mixed solution; dissolving 1 to 3 parts by weight of paracetamol in 80 parts by weight of tetrahydrofuran under an ultrasonic action to obtain a second mixed solution; mixing the first mixed solution with the second mixed solution to obtain a third mixed solution; evaporating and drying the third mixed solution to obtain the paracetamol-loaded nano-fiber composite material. The nano-fiber composite material is prepared from banana stalks as a raw material, and is taken as an introduction carrier of paracetamol, so that sustainable development of resources is realized; moreover, banana fiber is introduced into the nanometer material, so that efficient and cheap medicines can be prepared, and a good economic benefit is achieved.

Description

technical field [0001] The invention relates to the novel utilization field of plant fibers. More specifically, the present invention relates to a method for preparing a paracetamol-loaded nanofiber composite material. Background technique [0002] Banana fiber, stored in the bast of the banana tree, is bast fiber. It has natural excellent properties such as moisture absorption, breathability, antibacterial, anti-mildew, anti-ultraviolet, and no static electricity, and will not cause negative effects on the environment. It is an "inexhaustible and inexhaustible" environmentally friendly fiber. Banana fiber is used to make handbags and other decorative items, and is also processed into yarn on jute spinning equipment to make rope and sacks. Because banana fiber is light, shiny, and highly absorbent, it can also be made into curtains, towels, bed sheets, etc. [0003] At present, there are about 129 countries in the world that grow bananas, which are rich in banana fiber re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/38A61K47/34A61K31/167A61P29/00C08G63/08C08G63/78D21C5/00D21C9/02D21C3/02D21C3/00
Inventor 庞锦英谭登峰蓝春波莫羡忠刘钰馨李建鸣黎小燕林健英
Owner GUANGXI TEACHERS EDUCATION UNIV
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