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High-density grafted acid-based anti-biofilm material for catalyzing bacterial lysis and its preparation method and application

An anti-biological, high-density technology, which is applied in antibacterial, anti-corrosion materials, and super-hydrophilic fields. It can solve the problems of organic quaternary ammonium salts and metal ions with high biological toxicity and unfriendly environment, so as to avoid embedding antibiotics and reduce antibiotic resistance. Medicinal properties and low cost effects

Active Publication Date: 2020-11-20
杭州中科理化生物医药技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the defective of prior art, in order to solve organic quaternary ammonium salts and metal ion biological toxicity big, environment is unfriendly and antibiotic resistance problem, proposes the antibacterial and anticorrosion new method of not using antibacterial agent element and metal ion Technology, specifically a kind of anti-biofilm material grafted on the surface of high-density acid group to catalyze the cracking of bacteria and its preparation method and application

Method used

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  • High-density grafted acid-based anti-biofilm material for catalyzing bacterial lysis and its preparation method and application
  • High-density grafted acid-based anti-biofilm material for catalyzing bacterial lysis and its preparation method and application
  • High-density grafted acid-based anti-biofilm material for catalyzing bacterial lysis and its preparation method and application

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Embodiment Construction

[0026] 1. Antibacterial latex catheter

[0027] Step 1, the medical latex guide (1-4 cm length, 1 mm inner diameter) tube is cleaned with ethanol and dried;

[0028] Step 2, the latex catheter is placed in the plasma generator, vacuumized, and then argon gas is introduced into the reaction chamber (less than 400 millitorr, 2.4 cubic meters per hour), and the plasma excitation is started (output power 80 watts, 3 minutes);

[0029] Step 3, placing the plasma-activated latex catheter in air for 70 minutes to generate active reaction centers, and then placing the latex catheter in a pre-deoxidized container containing 40% acrylic acid solution, and sealing it;

[0030] Step 4, the polymerization reaction is carried out under anaerobic conditions, the temperature is maintained at 70 degrees, and the reaction is carried out for 12 hours;

[0031] Step 5, after the reaction, the latex catheter is washed with water, 30% sodium hydroxide, purified water, and ethanol in an ultrasonic ...

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Abstract

The invention discloses an anti-biofilm material grafted with high-density acid groups for catalyzing bacterium cracking, and a preparation method and an application thereof. The preparation method comprises the following steps: activating a material by using plasma to make the material generate surface free radicals; and exposing the material to air to generate active oxygen reaction centers, adding the material into an excessive amount of an acid group-containing unsaturated monomer, starting a surface polymerization reaction, and cleaning and drying the obtained material after the reactionis finished in order to obtain the anti-biofilm material with the surface being grafted with the high-density acid groups for catalyzing bacterium cracking. The high-density acid groups grafted on thesurface of the obtained material can generate superhydrophilic surface energy to catalyze the bacterium cracking in order to make the material have an antibacterial function, especially an anti-biofilm function, and the material adopts a bacterial lipid film as the target spot. Quaternary ammonium salts, metal ions and other antibacterial agents having large biotoxicity and being unfriendly to the environment are not used in the invention, so the material can be widely applied. Antibiotic embedding is avoided, and the risks of drug resistance, generation of super bacteria and emergency and out-of-control of epidemic diseases are reduced.

Description

technical field [0001] The invention belongs to the field of superhydrophilic, antibacterial and anticorrosion materials, in particular to a new technology of antibacterial, anticorrosion and anti-biofilm without antibacterial agents and metal ions, especially a kind of high-density grafted acid-based catalyzed anti-biofilm cracking agent Coating material and its preparation method and application. Background technique [0002] Human survival and health are continuously threatened by various bacteria and viruses. There are a large number of microorganisms in the human living environment, from daily fiber clothing, household appliances, sanitary ceramics, plastic films, to steel materials for construction, coatings, and disinfection treatment of drinking water. Reproduction, leading to material deterioration, corruption, mildew and wound suppuration infection, etc., a serious threat to human health. [0003] In recent years, events such as the Escherichia coli epidemic have...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/16C04B41/48C08L67/02C08L21/02
Inventor 梁俊峰
Owner 杭州中科理化生物医药技术有限公司
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