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Medical injectable gel and preparation method thereof

A gel and hyperbranched polymer technology, applied in the field of medical devices, can solve problems such as nerve tissue degeneration and cytotoxicity

Inactive Publication Date: 2018-02-16
HANGZHOU YAHUI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, residual glutaraldehyde in Bioglue can cause cytotoxicity and even neurological tissue degeneration

Method used

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  • Medical injectable gel and preparation method thereof
  • Medical injectable gel and preparation method thereof
  • Medical injectable gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Mix 30 mmol polyethylene glycol diacrylate (PEGDA, Mn=700Da), 10 mmol ethyl 2-bromoisobutyrate (EBriB), 0.25 mmol copper chloride (CuCl2) and 0.25 mmol N,N,N' ,N'',N''-pentamethyldiethylenetriamine (PMDETA) was added to a two-neck round bottom flask, and then 60 ml of 2-butanone was added. After the mixture is completely dissolved, fill it with argon for 30 minutes to exclude oxygen, add 0.125 mmol of L-ascorbic acid (L-AA) to the solution under the protection of argon, fill it with argon for 5 minutes, react at 50°C for 6 hours, and precipitate the mixed solution to A large amount of mixed solvent of n-hexane and ether (the volume ratio of n-hexane and ether is 1:2). After complete removal of the monomer, the polymer was dissolved in acetone and the solution was eluted through a short Al2O3 column to remove copper. After removing the acetone with a rotary evaporator, the viscous liquid obtained was an acrylate-terminated hyperbranched polymer HP-PEG ( 1 H-NMR such as...

Embodiment 2

[0032] Prepare glutaraldehyde aqueous solution with a concentration of 2.5%; prepare bovine serum albumin as a 10% (w / v) aqueous solution; at room temperature, mix glutaraldehyde solution and bovine serum albumin solution through a two-component syringe and spray After 2 minutes, a viscous hydrogel was obtained, the gel bursting strength was 6.2kPa, and the relative proliferation rate in the cytotoxicity test was 72%.

Embodiment 3

[0034] Dissolve 200mg of aldehyde-terminated hyperbranched polymer HP-PEG-CHO in 2mL of water for injection at a dissolution temperature of 25°C; prepare human serum albumin into a 10% (w / v) aqueous solution; at room temperature, Mix the aqueous solution of HP-PEG-CHO and human serum albumin solution through a two-component syringe and spray it. After 5 minutes, a viscous hydrogel is obtained. The gel bursting strength is 15.6kPa, and the relative proliferation in the cytotoxicity test The rate is 87%.

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Abstract

The invention provides medical injectable gel and a preparation method thereof. The medical injectable gel is prepared by mixing a formyl end-capped hyperbranched polymer HP-PEG-CHO solution with theconcentration of 2 percent to 20 percent (w / v) and a polyamino compound solution with the concentration of 2 percent to 20 percent (w / v) through a double-component injector and spraying, and utilizingformyl and amino to react to generate Schiff base to realize cross linking. The medical injectable gel provided by the invention has good biocompatibility and medical performance and finally can be completely degraded or absorbed in bodies. The medical injectable gel provided by the invention can be used as a surgical operation sealing agent and is used for sealing and enclosing a tissue wound oran implanted material and tissues in a surgical operation.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a medical injectable gel and a preparation method thereof. Background technique [0002] Hydrogel is a kind of three-dimensional network structure polymer with hydrophilic groups. Due to the physical crosslinking and chemical crosslinking between polymer chains, hydrogel can be swollen by water but insoluble in water and maintain a certain shape. The hydrogel type can provide better biocompatibility, which is beneficial to the repair and regeneration of damaged tissues, and has a wide range of applications in the field of biomedicine. In medicine, hydrogels can be used for wound dressing, anti-adhesion after surgery, hemostasis during surgery, tissue filling, and prevention of interstitial fluid leakage or gas leakage, etc. [0003] Hyperbranched polymer monomers have attracted more and more attention from researchers in the field of hydrogels, because hyperbranched structures can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/00A61L31/04A61L31/14A61L31/16C08F299/02
CPCA61L24/001A61L24/0015A61L24/0031A61L24/043A61L31/041A61L31/14A61L31/145A61L31/16A61L2300/412A61L2400/04A61L2400/06C08F299/026C08L71/02C08L79/02C08L77/04C08L89/00
Inventor 李丹汪伟王玮祝文斌朱家喜林高品
Owner HANGZHOU YAHUI BIOTECH CO LTD