Medical yttrium-90 carbon microspheres and preparation method thereof

A carbon microsphere, 90Y-EDTA technology, applied in the directions of radioactive physical shape, drug delivery, powder delivery, etc., can solve the problems of non-reusable, curative effect, etc., and achieve high utilization, good safety, and low release rate. Effect

Active Publication Date: 2018-02-23
CHENGDU NEW RADIOMEDICINE TECH CO LTD
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

There are yttrium-90 glass microspheres and cationic resin microspheres used for the treatment of liver cancer and the monoclonal antibody drug Zevalin ( 90 Y-mouse antibody), Zevalin ( 90 Y-mouse antibody) is an anti-CD20 monoclonal antibody drug that has been marketed in the United States, but because it is a mouse antibody treatment drug, a HAMA reaction will occur during use, and it cannot be used repeatedly, and its curative effect is limited

Method used

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Examples

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Embodiment

[0036] (1) Purification of carbon microspheres: Soak in organic solvents such as ethyl acetate, acetone or ethanol to remove fat; soak in dilute sodium hydroxide solution (0.1-0.5mol / L) to remove alkali-soluble impurities, and then repeatedly wash to weak alkali (pH value is 8-10); then soak in dilute nitric acid (0.1mol / L-0.5mol / L) to remove acid-soluble impurities, and wash until the pH value is 1-2.

[0037] (2) The commercially available premium pure 25g Y 2 o 3 Sealed in a quartz glass tube and placed in a thermal neutron flux higher than 5×10 13 n / cm 2 .s nuclear reactor irradiation, after 89 Y(n,r) 90 Y reaction generation 90 Y 2 o 3 , the specific activity is greater than 370G Bq(10Ci) / gY, 90 The nuclear purity of Y is not less than 99.9%, and then dissolve it with 300mL of HCl solution [where hydrochloric acid is diluted with 36-38% HCl solution and water at a ratio of 1:1 (mL / mL)]. After cooling to room temperature, transfer to a 500mL volumetric flask and d...

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Abstract

The invention discloses medical yttrium-90(<90>Y) carbon microspheres for treating tumors and a preparation method thereof. The medical yttrium-90 series carbon microspheres are complex compounds (90Y-EDTA) prepared by enabling a series carbon microsphere adsorbed <90>YCl3 solution and a disodium ethylene diamine tetraacetate solution to react. According to the medical yttrium-90 series carbon microspheres disclosed by the invention, the adsorption and curing efficiency on yttrium-90 nuclide is higher than 99 percent; after the carbon microspheres are further subjected to purification treatment, the releasing rate of the medical yttrium-90 series carbon microspheres on yttrium-90 is less than 0.01 percent; the medical yttrium-90(<90>Y) carbon microspheres have good biocompatibility and canbe used for radiotherapy in-vivo tumors.

Description

technical field [0001] The invention relates to a tumor radiotherapy drug and a preparation method thereof, in particular to a medical yttrium-90 carbon microsphere and a preparation method thereof. Background technique [0002] Internal radiation therapy (also known as interventional radiation therapy) is a method developed in recent years to treat malignant tumors. Internal radiation therapy using different radionuclides in various ways has been continuously applied to animal experiments and clinical trials, and has achieved great results. good curative effect. Radioactive microspheres for interventional therapy of tumors, because of the dual effects of internal radiation and vascular embolism, the therapeutic effect is more prominent than other embolization methods. The new type of radioactive microspheres with stable physical and chemical properties and high efficiency ( 90 Y glass microspheres and 90 Y resin microspheres) have been used to treat patients with liver ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/12A61K51/02A61P35/00A61K103/32
CPCA61K51/02A61K51/1251A61K51/12A61P35/00
Inventor 李茂良蔡继鸣胡学正葛强
Owner CHENGDU NEW RADIOMEDICINE TECH CO LTD
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