Ampicillin capsule and preparation method thereof

A technology of ampicillin capsules and ampicillin, which can be used in capsule delivery, pharmaceutical formulations, antibacterial drugs, etc., can solve problems such as poor bioavailability and slow onset of action

Inactive Publication Date: 2018-02-27
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the ampicillin in the existing common dosage form is slightly soluble in...

Method used

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  • Ampicillin capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] An ampicillin capsule, the drug-containing granules are made of the following raw materials in the weight ratio: 3g of ampicillin, 1g of cellulose acetate phthalate, 0.5g of rye starch with a water content of 10.5%, and ethanol with a concentration of 25%. 0.5g, sterile water 5g.

[0024] A preparation method for ampicillin capsules, comprising the steps of:

[0025] (1) Get ampicillin and carry out pulverization process by supersonic air flow, action time is 8min, makes ultrafine ampicillin particle;

[0026] (2) Take cellulose acetate phthalate and superfine ampicillin particles and dissolve them in sterile water, and perform ultrasonic treatment for 25s to prepare suspension A;

[0027] (3) Add dry starch to suspension A, ultrasonicate for 45 seconds, heat in a water bath at 60°C for 20 minutes, and cool to room temperature to obtain suspension B;

[0028] (4) Add ethanol to the suspension B, mix uniformly, and dry in vacuum to obtain a drug solid;

[0029] (5) Tr...

Embodiment 2

[0032] An ampicillin capsule, the drug-containing granules are made of the following raw materials in the weight ratio: 4 g of ampicillin, 1.2 g of cellulose acetate phthalate, 0.6 g of rye starch with a water content of 10.5%, and 25% cellulose acetate Ethanol 0.5g, sterile water 7g.

[0033] The preparation steps are the same as in Example 1.

Embodiment 3

[0035] An ampicillin capsule, the drug-containing granules are made of the following raw materials in the weight ratio: 5 g of ampicillin, 1.5 g of cellulose acetate phthalate, 0.7 g of rye starch with a water content of 11.5%, and 25% cellulose acetate Ethanol 0.5g, sterile water 10g.

[0036] The preparation steps are the same as in Example 1.

[0037] Get 3 groups of ampicillin capsule samples, according to release assay method (Chinese Pharmacopoeia edition in 2000 two appendix XD first method) (adopt the device of dissolution assay second method), with pH7.4 phosphate buffer saline 1000mL as solvent , the rotation speed is 200 revolutions per minute, operate according to the law, take 10mL of the solution at the first hour, 2 hours, 4 hours, 6 hours, 8 hours, 10 hours, and 12 hours, filter, and immediately add pH7. 4 Phosphate buffer 10mL as the test solution. According to spectrophotometry (Appendix IVA of Chinese Pharmacopoeia 2000 Edition), the absorbance value was m...

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Abstract

The present invention provides a kind of ampicillin capsule and preparation method thereof, relate to medical technology, comprise ampicillin, cellulose acetate phthalate, dry starch, ethanol; Treatment, the action time is 3‑8min; (2) get cellulose acetate phthalate and ultrafine ampicillin particles and dissolve them in sterile water, and ultrasonically treat them for 25‑75s to prepare suspension A; Add dry starch to the turbid solution A, ultrasonically treat it for 30-45s, and heat it in a water bath at 60°C for 15-20 minutes to obtain a suspension B; (4) Add ethanol to the suspension B, mix well, and dry in vacuum to obtain a solid drug product (5) Process the drug solid for 2-5min under the action of supersonic airflow, and screen the 150-200 mesh particles to obtain drug-containing particles; (6) fill the drug-containing particles into capsules to obtain ampicillin capsules. The ampicillin capsule of the invention disintegrates and dissolves rapidly and has high drug efficacy, thereby reducing the number of administrations, prolonging the interval of taking the medicines, and reducing the treatment cost.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an ampicillin capsule and a preparation method thereof. Background technique [0002] Ampicillin, also known as ampicillin, ampicillin, ampicillin, ampicillin, benasol, savicillin, savircillin, panbutin, ambixian, ambixian, ambilin, etc. Ampicillin is a broad-spectrum semi-synthetic penicillin with extremely low toxicity. The antimicrobial spectrum is similar to that of penicillin, and the bacteria that are sensitive to penicillin are less effective, and the antibacterial effect on Streptococcus viridans is similar to or slightly stronger than that of penicillin. Its efficacy against diphtheria bacillus, tetanus bacillus and actinomycetes is basically the same as that of penicillin. The effect on Enterococcus and Listeria is better than that of benzyl penicillin. It has no antibacterial effect on drug-resistant Staphylococcus and other bacteria that can produce penicillinase....

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/38A61K31/43A61P31/04
CPCA61K9/1652A61K9/0002A61K31/43
Inventor 操铖高煜
Owner HUAYI PHARMA ANHUI CO LTD
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