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Matrine chitosan membrane and preparation method thereof

A matrine chitosan film and a technique for a matrine chitosan film are applied in the field of matrine chitosan film and its preparation, and can solve the problem that no relevant reports on matrine chitosan film have been seen, short half-life, Affecting drug efficacy and other problems, achieving the effect of simple and easy preparation method, good physical properties, and avoiding the use of organic solvents

Inactive Publication Date: 2018-03-23
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zhang Yanhua prepared matrine chitosan microspheres, and the results showed that matrine chitosan microspheres have specific targeting and sustained release effects on matrine, but the short half-life and instability affect its efficacy ( Zhang Yanhua, Wei Yuhui, Liu Zhihong, et al. Preparation and drug release in vitro of matrine chitosan microspheres. Chinese Journal of Hospital Pharmacy, 2006,26(3):307-310.)
[0006] At present, there is no relevant report about matrine chitosan film

Method used

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  • Matrine chitosan membrane and preparation method thereof
  • Matrine chitosan membrane and preparation method thereof
  • Matrine chitosan membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 film

[0043] Configuration of CS solution: Dissolve CS in 1% (volume ratio) acetic acid solution to prepare 2L of 2% CS solution by mass. Pour the solution into a three-necked round-bottomed flask, and inject ozone O while stirring. 3 For degradation, take out about 250ml at the time of degradation of 0min, 15min, 30min, 45min, 60min, 75min, 90min, and 120min respectively.

[0044] Take 2.5ml of each of the above eight CS solutions with different degradation times, dissolve them in a mixed solvent of 0.1mol / l sodium acetate and 0.2mol / l acetic acid, and use a 50ml volumetric flask to make up a 1mg / ml CS solution.

[0045] With ozone (O 3 ) degradation method to degrade CS, the degradation of CS solution at room temperature at different times, and their viscosity-average molecular weight was measured by viscosity method. The relationship between CS viscosity-average molecular weight and degradation time is shown in Table 1, and the cha...

Embodiment 2

[0060] Select CSs with molecular weights of 310,000, 480,000, and 650,000, respectively, and make Mat / CS drug-loaded films with Mat contents of 10% and 12% (mass percent) according to the method in Example 1. After spraying gold, SEM observes its The surface morphology of the front and bottom surfaces; select CS with a molecular weight of 650,000, and make a Mat / CS drug-loaded film with a Mat content of 12% according to the method in Example 1, and observe its cross-sectional morphology by SEM after spraying gold.

[0061] The micro-morphological structure of the Mat / CS drug-loaded film was observed by scanning electron microscopy to understand the dispersion of plant-derived Mat drugs in the Mat / CS drug-loaded film. Figure 4-9 SEM pictures of Mat / CS drug-loaded membranes with different CS molecular weights and different Mat mass contents.

[0062] From Figure 4 It can be seen that the membrane front of the Mat / CS drug-loaded membrane ( Figure 4 B) No drug particles appea...

Embodiment 3

[0064] The in vitro release rate experiment of embodiment 3Mat / CS drug-loaded film

[0065] Accurately weigh the matrine reference substance, and put it in a measuring bottle to make a 0.2mg / ml solution. Draw 100, 200, 400, 600, 750, and 900 μl of solution with a microsampler, put them in a 60ml separating funnel, add 2×10 -4 mol / L bromothymol blue pH 7.6 buffer solution 10.00ml, chloroform 10.00ml, stopper and shake vigorously for 2min, let stand for about 2h, after the water layer and chloroform layer are completely separated, separate the chloroform layer. Absorbance was measured by UV spectrophotometer at a wavelength of 415 nm. When measuring, use 10.00ml of bromothymol blue buffer solution with a pH of 7.6, add 10.00ml of chloroform and shake as above, and separate the chloroform layer as a colorimetric blank. Use the measured absorbance as the ordinate and the concentration of matrine as the abscissa to measure the standard working curve of matrine. The fitted curve ...

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Abstract

The invention relates to a matrine chitosan membrane and a preparation method thereof. The matrine chitosan membrane is prepared by using chitosan as a matrix material, matrine as a medicine and glycerin as a plasticizer through a solution casting method, wherein mass ratio of chitosan to glycerin is 1:1-1.8; viscosity average molecular weight of chitosan is 5.6*104-65*104; and mass content of matrine is 6-14 wt%. According to the prepared matrine chitosan drug-loaded membrane, it is determined that the highest content of Mat in the Mat / CS biomembrane is 12% and it is observed through a SEM that the Mat medicine is gathered at the bottom of the biomembrane and in unsymmetrical distribution. By the sterilizing function of the natural traditional Chinese medicine matrine and good biocompatibility, bacterinertness and degradability of chitosan, matrine and chitosan are ingeniously combined together to form a slow-release drug biomembrane with good efficacy.

Description

technical field [0001] The invention belongs to the technical field of polymer membranes, and in particular relates to a matrine-chitosan membrane and a preparation method thereof. Background technique [0002] In recent years, people have carried out a series of studies on chitosan as a food preservation material. The food preservation film or coating made of chitosan has the advantages of being degradable and edible. It can not only prevent food from contacting with the outside world, prevent changes in water content in food, but also inhibit the growth of certain microorganisms and effectively prolong the life of food. shelf life. [0003] Chitosan (CS) is non-toxic, biodegradable, and has good biocompatibility. It has good film-forming properties, anti-blood coagulation, promotion of wound healing, and antiseptic and antibacterial functions. It has attracted much attention as a biomedical material (Yang Xuexia, Bu Guojian. A film for the treatment of oral ulcers and it...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4375A61K47/36A61K47/10A61P31/04
CPCA61K9/7007A61K31/4375A61K47/10A61K47/36
Inventor 张春雷李经华
Owner JINAN UNIVERSITY
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